Search Results - "Bergren, Sarah K."

Single luminal epithelial progenitors can generate prostate organoids in culture by Chua, Chee Wai, Shibata, Maho, Lei, Ming, Toivanen, Roxanne, Barlow, LaMont J., Bergren, Sarah K., Badani, Ketan K., McKiernan, James M., Benson, Mitchell C., Hibshoosh, Hanina, Shen, Michael M.

“…The intrinsic ability to exhibit self-organizing morphogenetic properties in ex vivo culture may represent a general property of tissue stem cells. Here we…”
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Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer by Lee, Suk Hyung, Hu, Wenhuo, Matulay, Justin T., Silva, Mark V., Owczarek, Tomasz B., Kim, Kwanghee, Chua, Chee Wai, Barlow, LaMont J., Kandoth, Cyriac, Williams, Alanna B., Bergren, Sarah K., Pietzak, Eugene J., Anderson, Christopher B., Benson, Mitchell C., Coleman, Jonathan A., Taylor, Barry S., Abate-Shen, Cory, McKiernan, James M., Al-Ahmadie, Hikmat, Solit, David B., Shen, Michael M.

“…Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human…”
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Luminal Cells Are Favored as the Cell of Origin for Prostate Cancer by Wang, Zhu A., Toivanen, Roxanne, Bergren, Sarah K., Chambon, Pierre, Shen, Michael M.

“…The identification of cell types of origin for cancer has important implications for tumor stratification and personalized treatment. For prostate cancer, the…”
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A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue by Talos, Flaminia, Mitrofanova, Antonina, Bergren, Sarah K., Califano, Andrea, Shen, Michael M.

“…To date, reprogramming strategies for generating cell types of interest have been facilitated by detailed understanding of relevant developmental regulatory…”
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Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation by Chua, Chee Wai, Epsi, Nusrat J, Leung, Eva Y, Xuan, Shouhong, Lei, Ming, Li, Bo I, Bergren, Sarah K, Hibshoosh, Hanina, Mitrofanova, Antonina, Shen, Michael M

“…Master regulatory genes of tissue specification play key roles in stem/progenitor cells and are often important in cancer. In the prostate, androgen receptor…”
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Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell-of-origin model for prostate cancer heterogeneity by Wang, Zhu A., Mitrofanova, Antonina, Bergren, Sarah K., Abate-Shen, Cory, Cardiff, Robert D., Califano, Andrea, Shen, Michael M.

“…A key issue in cancer biology is whether oncogenic transformation of different cell types of origin within an adult tissue gives rise to distinct tumour…”
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CRISPR/Cas9-Mediated Point Mutation in Nkx3.1 Prolongs Protein Half-Life and Reverses Effects Nkx3.1 Allelic Loss by Bowen, Cai, Shibata, Maho, Zhang, Hailan, Bergren, Sarah K, Shen, Michael M, Gelmann, Edward P

“…is the most commonly deleted gene in prostate cancer and is a gatekeeper suppressor. is haploinsufficient, and pathogenic reduction in protein levels may…”
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Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate by Hanoun, Maher, Arnal-Estapé, Anna, Maryanovich, Maria, Zahalka, Ali H., Bergren, Sarah K., Chua, Chee W., Leftin, Avigdor, Brodin, Patrik N., Shen, Michael M., Guha, Chandan, Frenette, Paul S.

“…In the prostate, stem and progenitor cell regenerative capacities have been ascribed to both basal and luminal epithelial cells. Here, we show that a rare…”
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Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS by Chow, Clement Y., Landers, John E., Bergren, Sarah K., Sapp, Peter C., Grant, Adrienne E., Jones, Julie M., Everett, Lesley, Lenk, Guy M., McKenna-Yasek, Diane M., Weisman, Lois S., Figlewicz, Denise, Brown, Robert H., Meisler, Miriam H.

“…Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P2 are responsible for the recessive peripheral-nerve disorder CMT4J. We now describe…”
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Fine mapping of an epilepsy modifier gene on mouse Chromosome 19 by Bergren, Sarah K, Rutter, Elizabeth D, Kearney, Jennifer A

“…Mutations in voltage-gated sodium channels are associated with several types of human epilepsy. Variable expressivity and penetrance are common features of…”
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Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a by Bergren, Sarah K, Chen, Shu, Galecki, Andrzej, Kearney, Jennifer A

“…Mutations in the voltage-gated sodium channels SCN 1 A and SCN 2 A are responsible for several types of human epilepsy. Variable expressivity among family…”
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Evidence for a direct role of the disease modifier SCNM1 in splicing by Howell, Viive M., Jones, Julie M., Bergren, Sarah K., Li, Li, Billi, Allison C., Avenarius, Matthew R., Meisler, Miriam H.

“…We originally isolated Scnm1 as a disease modifier gene that is required for efficient in vivo splicing of a mutant splice donor site in the sodium channel…”
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Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2 by Kearney, Jennifer A., Yang, Yan, Beyer, Barbara, Bergren, Sarah K., Claes, Lieve, DeJonghe, Peter, Frankel, Wayne N.

“…A mutation in the voltage-gated sodium-channel Scn2a results in moderate epilepsy in transgenic Scn2aQ54 mice maintained on a C57BL/6J strain background. The…”
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Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channelScn2a by Bergren, Sarah K, Chen, Shu, Galecki, Andrzej, Kearney, Jennifer A

“…Mutations in the voltage-gated sodium channels SCN1A and SCN2A are responsible for several types of human epilepsy. Variable expressivity among family members…”
Get full text