Search Results - "Bergoglio, V."

A new role for cytidine deaminase in the control of DNA replication and genomic stability by Lumeau, A., Frances, A., Madrid-Mencia, M., Ribeyre, C., Pillaire, M., Bergoglio, V., Torrisani, J., Lutzmann, M., Buscail, L., Hoffmann, J., Cordelier, P.

“…DNA spreading analysis and nucleotide incorporation studies demonstrate that CDA increases DNA synthesis efficiency during S and late G2/M phase of the cell…”
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Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures by Brellier, F, Bergoglio, V, Valin, A, Barnay, S, Chevallier-Lagente, O, Vielh, P, Spatz, A, Gorry, P, Avril, M-F, Magnaldo, T

“…Basal cell carcinoma of the skin is the most common type of cancer in humans. The majority of these tumors displays aberrant activation of the SONIC HEDGEHOG…”
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Nucleotide excision repair and related human diseases by Bergoglio, V, Magnaldo, T

“…Nucleotide excision repair (NER) of DNA-lesions is the most versatile DNA repair mechanism involved in genome maintenance, cell and organismal preservation…”
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The R438W polymorphism of human DNA polymerase lambda triggers cellular sensitivity to camptothecin by compromising the homologous recombination repair pathway by Capp, Jean-Pascal, Boudsocq, François, Bergoglio, Valérie, Trouche, Didier, Cazaux, Christophe, Blanco, Luis, Hoffmann, Jean-Sébastien, Canitrot, Yvan

“…The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to…”
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Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis by Bergoglio, Valérie, Pillaire, Marie-Jeanne, Lacroix-Triki, Magali, Raynaud-Messina, Brigitte, Canitrot, Yvan, Bieth, Anne, Garès, Michèle, Wright, Michel, Delsol, Georges, Loeb, Lawrence A, Cazaux, Christophe, Hoffmann, Jean-Sébastien

“…To reach the biological alterations that characterize cancer, the genome of tumor cells must acquire increased mutability resulting from a malfunction of a…”
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Localisation of human DNA polymerase kappa to replication foci by Bergoglio, Valérie, Bavoux, Clarisse, Verbiest, Vincent, Hoffmann, Jean-Sebastien, Cazaux, Christophe

“…The replication of the undamaged genomic DNA requires error-free DNA polymerases delta and epsilon as part of a protein complex that acts continuously along…”
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Enhanced expression and activity of DNA polymerase β in human ovarian tumor cells: impact on sensitivity towards antitumor agents by BERGOGLIO, Valérie, CANITROT, Yvan, HOGARTH, Linda, MINTO, Lynne, HOWELL, Stephen B, CAZAUX, Christophe, HOFFMANN, Jean-Sébastien

“…DNA polymerase beta, one of the most inaccurate DNA synthesizing enzymes, has been shown to confer genetic instability when up-regulated in cells, a situation…”
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Heterozygous mutations in the tumor suppressor gene PA TCHED provoke basal cell carcinoma-like features in human organotypic skin cultures by BRELLIER, F, BERGOGLIO, V, VALIN, A, BARNAY, S, CHEVALLIER-LAGENTE, O, VIELH, P, SPATZ, A, GORRY, P, AVRIL, M-F, MAGNALDO, T

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DNA polymerase beta can incorporate ribonucleotides during DNA synthesis of undamaged and CPD-damaged DNA by Bergoglio, Valérie, Ferrari, Elena, Hübscher, Ulrich, Cazaux, Christophe, Hoffmann, Jean Sébastien

“…Overexpression of the error-prone DNA polymerase beta (Pol beta) has been found to increase spontaneous mutagenesis by competing with the replicative…”
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Up-regulation of the error-prone DNA polymerase Β promotes pleiotropic genetic alterations and tumorigenesis by Bavoux, C., A.M., Leopoldino, Bergoglio, V., O-Wang, J., Ogi, T., Bieth, A., S.D.J., Pena, M.F, Poupon, Helleday, T., Tagawa, M., C.R., Machado, J.S., Hoffmann, Cazaux, C.

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