Search Results - "Berglund, Mark R."

Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide by Wang, Jingyao, Berglund, Mark R., Braden, Timothy, Embry, Matthew C., Johnson, Martin D., Groskreutz, Stephen R., Sayyed, Fareed Bhasha, Tsukanov, Sergey Vladimirovich, White, Timothy D., Jalan, Ankur, Seibert, Kevin D., Kopach, Michael E.

“…This study focused on investigating diketopiperazine (DKP) and the formation of associated double-amino-acid deletion impurities during linear solid-phase…”
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Quality by design of solid‐phase peptide/protein coupling reaction via mechanistic reaction kinetics modeling approach by Wang, Jingyao, Agrawal, Paridhi, Berglund, Mark R., Groh, Jennifer McClary, Kopach, Michael E., Seibert, Kevin D., Viswanath, Shekhar K.

“…The peptide coupling reaction is one of the most critical steps in the solid phase synthesis of therapeutic peptides/proteins. Improper reaction conditions can…”
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Development of a Mechanistic Amino Acid Activation Reaction Kinetics Model for Safe and Efficient Solid Phase Peptide Synthesis by Wang, Jingyao, Agrawal, Paridhi, Buser, Jonas Y., Embry, Matthew C., McFarland, Adam D., Berglund, Mark R., McClary Groh, Jennifer, Viswanath, Shekhar K.

“…Amino acid pre-activation is a critical reaction step during solid phase peptide synthesis due in part to the formation of impurities such as isomer,…”
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