Search Results - "Berglund, J Andrew"

Role of RNA structure in regulating pre-mRNA splicing by Warf, M. Bryan, Berglund, J. Andrew

“…Pre-mRNA splicing involves removing non-coding introns from RNA transcripts. It is carried out by the spliceosome, along with other auxiliary factors. In…”
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Transcriptome alterations in myotonic dystrophy skeletal muscle and heart by Wang, Eric T, Treacy, Daniel, Eichinger, Katy, Struck, Adam, Estabrook, Joseph, Olafson, Hailey, Wang, Thomas T, Bhatt, Kirti, Westbrook, Tony, Sedehizadeh, Sam, Ward, Amanda, Day, John, Brook, David, Berglund, J Andrew, Cooper, Thomas, Housman, David, Thornton, Charles, Burge, Christopher

“…Abstract Myotonic dystrophy (dystrophia myotonica, DM) is a multi-systemic disease caused by expanded CTG or CCTG microsatellite repeats. Characterized by…”
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Alternative Splicing Outcomes Across an RNA-Binding Protein Concentration Gradient by Ellis, Joseph A., Hale, Melissa A., Cleary, John D., Wang, Eric T., Andrew Berglund, J.

“…[Display omitted] •An MBNL1- and RBFOX1-inducible HEK-293 cell line used to characterize alternative splicing.•RBFOX1 modulated alternative spicing outcomes,…”
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Pseudouridine Modification Inhibits Muscleblind-like 1 (MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility by deLorimier, Elaine, Hinman, Melissa N., Copperman, Jeremy, Datta, Kausiki, Guenza, Marina, Berglund, J. Andrew

“…Myotonic dystrophy type 2 is a genetic neuromuscular disease caused by the expression of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type…”
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Pentamidine reverses the splicing defects associated with myotonic dystrophy by Warf, M. Bryan, Nakamori, Masayuki, Matthys, Catherine M, Thornton, Charles A, Berglund, J. Andrew

“…Myotonic dystrophy (DM) is a genetic disorder caused by the expression (as RNA) of expanded CTG or CCTG repeats. The alternative splicing factor MBNL1 is…”
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Disease-associated inosine misincorporation into RNA hinders translation by Schroader, Jacob H, Jones, Lindsey A, Meng, Ryan, Shorrock, Hannah K, Richardson, Jared I, Shaughnessy, Sharon M, Lin, Qishan, Begley, Thomas J, Berglund, J Andrew, Fuchs, Gabriele, Handley, Mark T, Reddy, Kaalak

“…Abstract Failure to prevent accumulation of the non-canonical nucleotide inosine triphosphate (ITP) by inosine triphosphate pyrophosphatase (ITPase) during…”
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Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy by Wagner, Stacey D, Struck, Adam J, Gupta, Riti, Farnsworth, Dylan R, Mahady, Amy E, Eichinger, Katy, Thornton, Charles A, Wang, Eric T, Berglund, J Andrew

“…Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the…”
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Actinomycin D Specifically Reduces Expanded CUG Repeat RNA in Myotonic Dystrophy Models by Siboni, Ruth B., Nakamori, Masayuki, Wagner, Stacey D., Struck, Adam J., Coonrod, Leslie A., Harriott, Shanee A., Cass, Daniel M., Tanner, Matthew K., Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is an inherited disease characterized by the inability to relax contracted muscles. Affected individuals carry large CTG…”
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Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules by Reddy, Kaalak, Jenquin, Jana R, Cleary, John D, Berglund, J Andrew

“…This review, one in a series on myotonic dystrophy (DM), is focused on the development and potential use of small molecules as therapeutics for DM. The complex…”
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An engineered RNA binding protein with improved splicing regulation by Hale, Melissa A, Richardson, Jared I, Day, Ryan C, McConnell, Ona L, Arboleda, Juan, Wang, Eric T, Berglund, J Andrew

“…Abstract The muscleblind-like (MBNL) family of proteins are key developmental regulators of alternative splicing. Sequestration of MBNL proteins by expanded…”
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A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels by Reddy, Kaalak, Jenquin, Jana R., McConnell, Ona L., Cleary, John D., Richardson, Jared I., Pinto, Belinda S., Haerle, Maja C., Delgado, Elizabeth, Planco, Lori, Nakamori, Masayuki, Wang, Eric T., Berglund, J. Andrew

“…A CTG repeat expansion in the DMPK gene is the causative mutation of myotonic dystrophy type 1 (DM1). Transcription of the expanded CTG repeat produces toxic…”
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Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice by Pattamatta, Amrutha, Nguyen, Lien, Olafson, Hailey R, Scotti, Marina M, Laboissonniere, Lauren A, Richardson, Jared, Berglund, J Andrew, Zu, Tao, Wang, Eric T, Ranum, Laura P W

“…C9orf72 ALS/FTD patients show remarkable clinical heterogeneity, but the complex biology of the repeat expansion mutation has limited our understanding of the…”
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Autoregulated Splicing of muscleblind-like 1 (MBNL1) Pre-mRNA by Gates, Devika P., Coonrod, Leslie A., Berglund, J. Andrew

“…Muscleblind-like 1 (MBNL1) is a splicing factor whose improper cellular localization is a central component of myotonic dystrophy. In myotonic dystrophy, the…”
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The potential of engineered eukaryotic RNA‐binding proteins as molecular tools and therapeutics by Shotwell, Carl R., Cleary, John D., Berglund, J. Andrew

“…Eukaroytic RNA‐binding proteins (RBPs) recognize and process RNAs through recognition of their sequence motifs via RNA‐binding domains (RBDs). RBPs usually…”
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Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line by Bonenfant, Gaston, Meng, Ryan, Shotwell, Carl, Badu, Pheonah, Payne, Anne F, Ciota, Alexander T, Sammons, Morgan A, Berglund, J Andrew, Pager, Cara T

“…The alternative splicing of pre-mRNAs expands a single genetic blueprint to encode multiple, functionally diverse protein isoforms. Viruses have previously…”
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protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing by Warf, M. Bryan, Diegel, Julien V, von Hippel, Peter H, Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is a genetic disorder linked to a (CTG)n repeat expansion in the 3' untranslated region of the DMPK gene. Upon transcription in…”
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Three-Dimensional Real-Time Tracking of Nanoparticles at an Oil–Water Interface by Du, Kan, Liddle, J. Alexander, Berglund, Andrew J

“…Single-particle tracking with real-time feedback control can be used to study three-dimensional nanoparticle transport dynamics. We apply the method to study…”
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Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 Models by Siboni, Ruth B, Bodner, Micah J, Khalifa, Muhammad M, Docter, Aaron G, Choi, Jessica Y, Nakamori, Masayuki, Haley, Michael M, Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is a disease characterized by errors in alternative splicing, or “mis-splicing”. The causative agent of mis-splicing in DM1 is…”
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CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity by Perez, Barbara A, Shorrock, Hannah K, Banez‐Coronel, Monica, Zu, Tao, Romano, Lisa EL, Laboissonniere, Lauren A, Reid, Tammy, Ikeda, Yoshio, Reddy, Kaalak, Gomez, Christopher M, Bird, Thomas, Ashizawa, Tetsuo, Schut, Lawrence J, Brusco, Alfredo, Berglund, J Andrew, Hasholt, Lis F, Nielsen, Jorgen E, Subramony, SH, Ranum, Laura PW

“…Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder caused by a CTG•CAG expansion, is unusual because most individuals that…”
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Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy by Hinman, Melissa N, Richardson, Jared I, Sockol, Rose A, Aronson, Eliza D, Stednitz, Sarah J, Murray, Katrina N, Berglund, J Andrew, Guillemin, Karen

“…The muscleblind RNA binding proteins (MBNL1, MBNL2, and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative…”
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