Search Results - "Berglund, Eva C"
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A gene transfer agent and a dynamic repertoire of secretion systems hold the keys to the explosive radiation of the emerging pathogen Bartonella
Published in PLoS genetics (01-03-2013)“…Gene transfer agents (GTAs) randomly transfer short fragments of a bacterial genome. A novel putative GTA was recently discovered in the mouse-infecting…”
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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
Published in Genome Biology (01-01-2013)“…BACKGROUND: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have…”
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Mutational patterns and clonal evolution from diagnosis to relapse in pediatric acute lymphoblastic leukemia
Published in Scientific reports (2021)“…The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole…”
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The Mutational Landscape in Pediatric Acute Lymphoblastic Leukemia Deciphered by Whole Genome Sequencing
Published in Human mutation (01-01-2015)“…ABSTRACT Genomic characterization of pediatric acute lymphoblastic leukemia (ALL) has identified distinct patterns of genes and pathways altered in patients…”
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Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles
Published in Journal of hematology and oncology (14-08-2017)“…Structural chromosomal rearrangements that lead to expressed fusion genes are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed…”
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Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes
Published in Oncotarget (2016)“…To characterize the mutational patterns of acute lymphoblastic leukemia (ALL) we performed deep next generation sequencing of 872 cancer genes in 172…”
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Run-off replication of host-adaptability genes is associated with gene transfer agents in the genome of mouse-infecting Bartonella grahamii
Published in PLoS genetics (01-07-2009)“…The genus Bartonella comprises facultative intracellular bacteria adapted to mammals, including previously recognized and emerging human pathogens. We report…”
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Accurate detection of subclonal single nucleotide variants in whole genome amplified and pooled cancer samples using HaloPlex target enrichment
Published in BMC genomics (05-12-2013)“…Target enrichment and resequencing is a widely used approach for identification of cancer genes and genetic variants associated with diseases. Although cost…”
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A genome-wide study of recombination rate variation in Bartonella henselae
Published in BMC evolutionary biology (11-05-2012)“…Rates of recombination vary by three orders of magnitude in bacteria but the reasons for this variation is unclear. We performed a genome-wide study of…”
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Genome dynamics of Bartonella grahamii in micro-populations of woodland rodents
Published in BMC genomics (04-03-2010)“…Rodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the…”
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Computational resources in infectious disease: limitations and challenges
Published in PLoS computational biology (01-10-2009)“… [...]scientists with expertise in other fields of research, such as clinical microbiology and ecology, are just beginning to face the challenge of handling,…”
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Next-generation sequencing technologies and applications for human genetic history and forensics
Published in Investigative genetics (24-11-2011)“…Rapid advances in the development of sequencing technologies in recent years have enabled an increasing number of applications in biology and medicine. Here,…”
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Rapid diversification by recombination in Bartonella grahamii from wild rodents in Asia contrasts with low levels of genomic divergence in Northern Europe and America
Published in Molecular ecology (01-06-2010)“…Bartonella is a genus of vector-borne bacteria that infect the red blood cells of mammals, and includes several human-specific and zoonotic pathogens…”
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Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass
Published in Twin research and human genetics (01-12-2015)“…The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy…”
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A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen Bartonella: e1003393
Published in PLoS genetics (01-03-2013)“…Gene transfer agents (GTAs) randomly transfer short fragments of a bacterial genome. A novel putative GTA was recently discovered in the mouse-infecting…”
Get full text
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Computational Resources in Infectious Disease: Limitations and Challenges: e1000481
Published in PLoS computational biology (01-10-2009)“…[...]scientists with expertise in other fields of research, such as clinical microbiology and ecology, are just beginning to face the challenge of handling,…”
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17
Digital gene expression profiling of primary acute lymphoblastic leukemia cells
Published in Leukemia (01-06-2012)“…We determined the genome-wide digital gene expression (DGE) profiles of primary acute lymphoblastic leukemia (ALL) cells from 21 patients taking advantage of…”
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Run-Off Replication of Host-Adaptability Genes Is Associated with Gene Transfer Agents in the Genome of Mouse-Infecting Bartonella grahamii: e1000546
Published in PLoS genetics (01-07-2009)“…The genus Bartonella comprises facultative intracellular bacteria adapted to mammals, including previously recognized and emerging human pathogens. We report…”
Get full text
Journal Article