Search Results - "Bergles, D."

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus by Bergles, Dwight E, Roberts, J. David B, Somogyi, Peter, Jahr, Craig E

“…Fast excitatory neurotransmission in the central nervous system occurs at specialized synaptic junctions between neurons, where a high concentration of…”
Get full text

Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS by Regan, Melissa R, Huang, Yanhua H, Kim, Yu Shin, Dykes-Hoberg, Margaret I, Jin, Lin, Watkins, Andrew M, Bergles, Dwight E, Rothstein, Jeffrey D

“…Glutamate transporters regulate excitatory neurotransmission and prevent glutamate-mediated excitotoxicity in the CNS. To better study the cellular and…”
Get full text

Specificity of antibodies: Unexpected cross-reactivity of antibodies directed against the excitatory amino acid transporter 3 (EAAT3) by Holmseth, S., Dehnes, Y., Bjørnsen, L.P., Boulland, J.-L., Furness, D.N., Bergles, D., Danbolt, N.C.

“…Specific antibodies are essential tools for identifying individual proteins in biological samples. While generation of antibodies is often straightforward,…”
Get full text

4-Carboxymethoxy-5,7-dinitroindolinyl-Glu: an improved caged glutamate for expeditious ultraviolet and two-photon photolysis in brain slices by Ellis-Davies, Graham C R, Matsuzaki, Masanori, Paukert, Martin, Kasai, Haruo, Bergles, Dwight E

Get full text

Synaptic activation of glutamate transporters in hippocampal astrocytes by Bergles, D E, Jahr, C E

“…Glutamate transporters in the CNS are expressed in neurons and glia and mediate high affinity, electrogenic uptake of extracellular glutamate. Although glia…”
Get full text

Excitatory actions of norepinephrine on multiple classes of hippocampal CA1 interneurons by Bergles, DE, Doze, VA, Madison, DV, Smith, SJ

“…Norepinephrine (NE) causes an increase in the frequency of inhibitory postsynaptic potentials in CA1 pyramidal neurons in vitro. The possibility that this…”
Get full text

Clearance of glutamate inside the synapse and beyond by Bergles, Dwight E, Diamond, Jeffrey S, Jahr, Craig E

“…The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished — indeed, new evidence is fanning the flames…”
Get full text

Glial Contribution to Glutamate Uptake at Schaffer Collateral-Commissural Synapses in the Hippocampus by Bergles, Dwight E, Jahr, Craig E

“…Astrocytes in the hippocampus express high-affinity glutamate transporters that are important for lowering the concentration of extracellular glutamate after…”
Get full text

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex by Hughes, Ethan G., Orthmann-Murphy, Jennifer L., Langseth, Abraham J., Bergles, Dwight E.

“…Oligodendrocyte generation in the adult CNS provides a means to adapt the properties of circuits to changes in life experience. However, little is known about…”
Get full text

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain by Hughes, Ethan G, Kang, Shin H, Fukaya, Masahiro, Bergles, Dwight E

“…In this study, the authors use time-lapse in vivo two-photon imaging to elucidate the dynamics of NG2 + gial cells in the cortex. They find that proliferation…”
Get full text

Mossy fiber growth and synaptogenesis in rat hippocampal slices in vitro by Dailey, ME, Buchanan, J, Bergles, DE, Smith, SJ

“…Hippocampal slices from early postnatal rat were used to study mossy fiber (MF) growth and synaptogenesis. The ability of MFs to form new giant synapses within…”
Get full text

Glutamate Transporter Currents in Bergmann Glial Cells Follow the Time Course of Extrasynaptic Glutamate by Bergles, D E, Dzubay, J A, Jahr, C E

“…Glutamate transporters in the central nervous system are expressed in both neurons and glia, they mediate high affinity, electrogenic uptake of glutamate, and…”
Get full text

Glutamate Release Monitored with Astrocyte Transporter Currents during LTP by Diamond, Jeffrey S, Bergles, Dwight E, Jahr, Craig E

“…Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release,…”
Get full text

Control of Cilia in the Branchial Basket of Ciona intestinalis (Ascidacea) by Bergles, Dwight, Tamm, Sidney

“…We investigated arrest and inactivation responses of stigmatal cilia in the branchial basket of the ascidian, Ciona intestinalis. Using an improved preparation…”
Get full text

Developmental origin of oligodendrocytes determines their function in the adult brain by Foerster, Sarah, Floriddia, Elisa M., van Bruggen, David, Kukanja, Petra, Hervé, Bastien, Cheng, Shangli, Kim, Eosu, Phillips, Benjamin U., Heath, Christopher J., Tripathi, Richa B., Call, Cody, Bartels, Theresa, Ridley, Katherine, Neumann, Björn, López-Cruz, Laura, Crawford, Abbe H., Lynch, Cian J., Serrano, Manuel, Saksida, Lisa, Rowitch, David H., Möbius, Wiebke, Nave, Klaus-Armin, Rasband, Matthew N., Bergles, Dwight E., Kessaris, Nicoletta, Richardson, William D., Bussey, Timothy J., Zhao, Chao, Castelo-Branco, Gonçalo, Franklin, Robin J. M.

“…In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three…”
Get full text

β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression by Toan, Shuy Vang, Fisher, Paul B, Gupta, Pankaj, Bruijn, Lucie I, Jin, Lin, Vidensky, Svetlana, Rothstein, Jeffrey D, Regan, Melissa R, Patel, Sarjubhai, Bergles, Dwight E, Chung, Dorothy S, Haenggeli, Christine, Dykes Hoberg, Margaret, Su, Zao-zhong, Huang, Yanhua H

“…Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1…”
Get full text

Glutamate transporters bring competition to the synapse by Huang, Yanhua H, Bergles, Dwight E

“…Glutamate transporters (GluTs) prevent the accumulation of glutamate and influence the occupancy of receptors at synapses. The ability of extrasynaptic NMDA…”
Get full text

Synaptic signaling between GABAergic interneurons and oligodendrocyte precursor cells in the hippocampus by Bergles, Dwight E, Lin, Shih-chun

“…Oligodendrocyte precursor cells (OPCs) express receptors for many neurotransmitters, but the mechanisms responsible for their activation are poorly understood…”
Get full text

Climbing Fiber Innervation of NG2-Expressing Glia in the Mammalian Cerebellum by Lin, Shih-chun, Huck, Jojanneke H.J., Roberts, J. David B., Macklin, Wendy B., Somogyi, Peter, Bergles, Dwight E.

“…The molecular layer of the cerebellar cortex is populated by glial progenitors that express ionotropic glutamate receptors and extend numerous processes among…”
Get full text

Astrocyte Glutamate Transporters Regulate Metabotropic Glutamate Receptor-Mediated Excitation of Hippocampal Interneurons by Huang, Yanhua H, Sinha, Saurabh R, Tanaka, Kohichi, Rothstein, Jeffrey D, Bergles, Dwight E

“…Clearance of extracellular glutamate is essential for limiting the activity of metabotropic glutamate receptors (mGluRs) at excitatory synapses; however, the…”
Get full text