Search Results - "Bergholdt, Regine"

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression by BERGHOLDT, Regine, BRORSSON, Caroline, PALLEJA, Albert, BERCHTOLD, Lukas A, FLØYEL, Tina, BANG-BERTHELSEN, Claus Heiner, STENSGAARD FREDERIKSEN, Klaus, JUHL JENSEN, Lars, STØRLING, Joachim, POCIOT, Flemming

“…Genome-wide association studies (GWAS) have heralded a new era in susceptibility locus discovery in complex diseases. For type 1 diabetes, >40 susceptibility…”
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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients by Fløyel, Tina, Brorsson, Caroline, Nielsen, Lotte B., Miani, Michela, Bang-Berthelsen, Claus Heiner, Friedrichsen, Martin, Overgaard, Anne Julie, Berchtold, Lukas A., Wiberg, Anna, Poulsen, Pernille, Hansen, Lars, Rosinger, Silke, Boehm, Bernhard O., Ram, Ramesh, Nguyen, Quang, Mehta, Munish, Morahan, Grant, Concannon, Patrick, Bergholdt, Regine, Nielsen, Jens H., Reinheckel, Thomas, von Herrath, Matthias, Vaag, Allan, Eizirik, Decio Laks, Mortensen, Henrik B., Størling, Joachim, Pociot, Flemming

“…Over 40 susceptibility loci have been identified for type 1 diabetes (T1D). Little is known about how these variants modify disease risk and progression. Here,…”
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Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining by Kirk, Isa Kristina, Simon, Christian, Banasik, Karina, Holm, Peter Christoffer, Haue, Amalie Dahl, Jensen, Peter Bjødstrup, Juhl Jensen, Lars, Rodríguez, Cristina Leal, Pedersen, Mette Krogh, Eriksson, Robert, Andersen, Henrik Ullits, Almdal, Thomas, Bork-Jensen, Jette, Grarup, Niels, Borch-Johnsen, Knut, Pedersen, Oluf, Pociot, Flemming, Hansen, Torben, Bergholdt, Regine, Rossing, Peter, Brunak, Søren

“…Diabetes is a diverse and complex disease, with considerable variation in phenotypic manifestation and severity. This variation hampers the study of…”
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Neutralizing Anti-IL20 Antibody Treatment Significantly Modulates Low Grade Inflammation without Affecting HbA1c in Type 2 Diabetic db/db Mice by Mayer, Christopher, Bergholdt, Regine, Cucak, Helena, Rolin, Bidda Charlotte, Sams, Anette, Rosendahl, Alexander

“…Low grade inflammation is present in pre-clinical and human type 2 diabetes. In this process, several cytokines like IL-1β and inflammatory cells like…”
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Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and β-cell apoptosis by Berchtold, Lukas Adrian, Størling, Zenia Marian, Ortis, Fernanda, Lage, Kasper, Bang-Berthelsen, Claus, Bergholdt, Regine, Hald, Jacob, Brorsson, Caroline Anna, Eizirik, Decio Laks, Pociot, Flemming, Brunak, Søren, Størling, Joachim

“…Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-cells. Although the disease has a strong genetic component, and…”
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A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3 by Concannon, Patrick, Onengut-Gumuscu, Suna, Todd, John A, Smyth, Deborah J, Pociot, Flemming, Bergholdt, Regine, Akolkar, Beena, Erlich, Henry A, Hilner, Joan E, Julier, Cécile, Morahan, Grant, Nerup, Jørn, Nierras, Concepcion R, Chen, Wei-Min, Rich, Stephen S

“…A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3 Patrick Concannon 1 2 , Suna Onengut-Gumuscu 2 3 , John A. Todd 4 , Deborah J. Smyth 4…”
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The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes by Brorsson, Caroline, Tue Hansen, Niclas, Bergholdt, Regine, Brunak, Søren, Pociot, Flemming

“…The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in…”
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Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY) by Boesgaard, Trine W, Pruhova, Stepanka, Andersson, Ehm A, Cinek, Ondrej, Obermannova, Barbora, Lauenborg, Jeannet, Damm, Peter, Bergholdt, Regine, Pociot, Flemming, Pisinger, Charlotta, Barbetti, Fabrizio, Lebl, Jan, Pedersen, Oluf, Hansen, Torben

“…Insulin gene (INS) mutations have recently been described as a common cause of permanent neonatal diabetes (PNDM) and a rare cause of diabetes diagnosed in…”
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PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits by CHELALA, Claude, DUCHATELET, Sabine, JOFFRET, Marie-Line, BERGHOLDT, Regine, DUBOIS -LAFORGUE, Danièle, GHANDIL, Pegah, POCIOT, Flemming, CAILLAT-ZUCMAN, Sophie, TIMSIT, José, JULIER, Cécile

“…PTPN22 R620W Functional Variant in Type 1 Diabetes and Autoimmunity Related Traits Claude Chelala 1 2 , Sabine Duchatelet 1 2 , Marie-Line Joffret 1 2 , Regine…”
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Genetic Risk Score Modelling for Disease Progression in New-Onset Type 1 Diabetes Patients: Increased Genetic Load of Islet-Expressed and Cytokine-Regulated Candidate Genes Predicts Poorer Glycemic Control by Hvidoere Study Group on Childhood Diabetes, Joachim, Størling, Joachim, Mortensen, Henrik B., Hansen, Lars, Bergholdt, Regine, Kaur, Simranjeet, Andersen, Marie-Louise M., Nielsen, Lotte B., Brorsson, Caroline, Pociot, Flemming

“…Genome-wide association studies (GWAS) have identified over 40 type 1 diabetes risk loci. The clinical impact of these loci on β-cell function during disease…”
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Expression profiling of human genetic and protein interaction networks in type 1 diabetes by Bergholdt, Regine, Brorsson, Caroline, Lage, Kasper, Nielsen, Jens Høiriis, Brunak, Søren, Pociot, Flemming

“…Proteins contributing to a complex disease are often members of the same functional pathways. Elucidation of such pathways may provide increased knowledge…”
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CBLB variants in type 1 diabetes and their genetic interaction with CTLA4 by Bergholdt, Regine, Taxvig, Camilla, Eising, Stefanie, Nerup, Jørn, Pociot, Flemming

“…Type 1 diabetes (T1D) is a multifactorial disease with genetic and environmental components involved. Recent studies of an animal model of T1D, the Komeda…”
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Clinical trial protocol: TRANSCEND 1 – an observational study of patients with moderate Parkinson’s disease (P2-11.002) by Gesine, Paul-Visse, Widner, Håkan, Bergholdt, Regine, Frimer-Larsen, Helle, Mathiasen, Ida Stenfeldt, Nielsen, Anne Møller, Barker, Roger

“…Abstract only…”
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Genome-Wide Association Scan for Type 1 Diabetes Susceptibility Genes in a Danish Population by Brorsson, Caroline, PhD Student, Steno Diabetes Center, Gentofte, Swiergala, Elzbieta, Lab Manager, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, Rapacki, Kristoffer, Computer Scientist, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Bergholdt, Regine, Research Fellow, Steno Diabetes Center, Gentofte, Purcell, Shaun, Assistant Professor, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, Field, Leigh, Professor, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, Pociot, Flemming, Professor, Steno Diabetes Center, Gentofte

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Induction of antigenic immune tolerance to delay type 1 diabetes – challenges for clinical translation by Wesley, Johnna D., Pagni, Philippe P., Bergholdt, Regine, Kreiner, Frederik Flindt, von Herrath, Matthias

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Induction of antigenic immune tolerance to delay type 1 diabetes – challenges for clinical translation by Wesley, Johnna D., Pagni, Philippe P., Bergholdt, Regine, Kreiner, Frederik Flindt, von Herrath, Matthias

“…Dissect the field of antigen-specific immunotherapy (ASIT) in type 1 diabetes (T1D), highlighting the major barriers currently blocking clinical translation…”
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Oxidative DNA damage after transplantation of the liver and small intestine in pigs by Loft, S, Larsen, P N, Rasmussen, A, Fischer-Nielsen, A, Bondesen, S, Kirkegaard, P, Rasmussen, L S, Ejlersen, E, Tornøe, K, Bergholdt, R

“…Oxidative damage is thought to play an important role in ischemia/reperfusion injury, including the outcome of transplantation of the liver and intestine. We…”
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Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R⁺ T cells by von Scholten, Bernt Johan, Rosendahl, Alexander, Hasbak, Philip, Bergholdt, Regine, Kjaer, Andreas, Rossing, Peter, Hansen, Tine W

“…Low-grade systemic inflammation is considered to participate in the progression of type 2 diabetes (T2D) and in diabetic complications. To determine if…”
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No difference in vitamin D levels between children newly diagnosed with type 1 diabetes and their healthy siblings: a 13-year nationwide Danish study by Thorsen, Steffen U, Mortensen, Henrik B, Carstensen, Bendix, Fenger, Mogens, Thuesen, Betina H, Husemoen, Lise Lotte, Bergholdt, Regine, Brorsson, Caroline, Pociot, Flemming, Linneberg, Allan, Svensson, Jannet

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No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study by Thorsen, Steffen U, Mortensen, Henrik B, Carstensen, Bendix, Fenger, Mogens, Thuesen, Betina H, Husemoen, Lotte, Bergholdt, Regine, Brorsson, Caroline, Pociot, Flemming, Linneberg, Allan, Svensson, Jannet

“…Background Vitamin D, certain single nucleotide polymorphisms (SNPs) in the vitamin D‐receptor (VDR) gene and vitamin D metabolism genes have been associated…”
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