Bioceramics and bone healing

Bioceramics and bone healing

Calcium phosphates have long been used as synthetic bone grafts. Recent studies have shown that the modulation of composition and textural properties, such as nano-, micro- and macro-porosity, is a powerful strategy to control and synchronize material resorption and bone formation.Biomimetic calcium...

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Bibliographic Details
Published in:EFORT Open Reviews Vol. 3; no. 5; pp. 173 - 183
Main Authors: Ginebra, Maria-Pau, Espanol, Montserrat, Maazouz, Yassine, Bergez, Victor, Pastorino, David
Format: Journal Article Publication
Language:English
Published: England BioScientifica Ltd 01-05-2018
British Editorial Society of Bone and Joint Surgery
Subjects:
Bioceramics
Biomaterials
Biomedical materials
Bone composition
Bone Graft
Bone grafts
Bone growth
Bone Healing
Bone resorption
Calcium Phosphate
Calcium phosphates
Enginyeria biomèdica
Fosfat de calci
High temperature
Immunosuppressive agents
Instructional Lecture: General Orthopaedics
Low temperature
Mechanical properties
Osteogenesis
Porosity
Regeneration
Skin & tissue grafts
Àrees temàtiques de la UPC
Bioceramics
bone graft
calcium phosphate
bone healing
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Summary:Calcium phosphates have long been used as synthetic bone grafts. Recent studies have shown that the modulation of composition and textural properties, such as nano-, micro- and macro-porosity, is a powerful strategy to control and synchronize material resorption and bone formation.Biomimetic calcium phosphates, which closely mimic the composition and structure of bone mineral, can be produced using low-temperature processing routes, and offer the possibility to modulate the material properties to a larger extent than conventional high temperature sintering processes.Advanced technologies open up new possibilities in the design of bioceramics for bone regeneration; 3D-printing technologies, in combination with the development of hybrid materials with enhanced mechanical properties, supported by finite element modelling tools, are expected to enable the design and fabrication of mechanically competent patient-specific bone grafts.The association of ions, drugs and cells allows leveraging of the osteogenic potential of bioceramic scaffolds in compromised clinical situations, where the intrinsic bone regeneration potential is impaired. Cite this article: Open Rev 2018;3 DOI: 10.1302/2058-5241.3.170056.
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ISSN:2058-5241
2396-7544
2058-5241
DOI:10.1302/2058-5241.3.170056