Search Results - "Bergeron, John J. M."

Mass spectrometry in high-throughput proteomics: ready for the big time by Nilsson, Tommy, Bergeron, John J M, Mann, Matthias, Aebersold, Ruedi, Yates, John R, Bairoch, Amos

“…Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected…”
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ARFGAP1 is dynamically associated with lipid droplets in hepatocytes by Gannon, Joan, Fernandez-Rodriguez, Julia, Alamri, Hussam, Feng, Shi Bo, Kalantari, Fariba, Negi, Sarita, Wong, Amy H Y, Mazur, Alexander, Asp, Lennart, Fazel, Ali, Salman, Ayat, Lazaris, Anthoula, Metrakos, Peter, Bergeron, John J M, Nilsson, Tommy

“…The ARF GTPase Activating Protein 1 (ARFGAP1) associates mainly with the cytosolic side of Golgi cisternal membranes where it participates in the formation of…”
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Compartmentalization of membrane trafficking, glucose transport, glycolysis, actin, tubulin and the proteasome in the cytoplasmic droplet/Hermes body of epididymal sperm by Au, Catherine E., Hermo, Louis, Byrne, Elliot, Smirle, Jeffrey, Fazel, Ali, Kearney, Robert E., Smith, Charles E., Vali, Hojatollah, Fernandez-Rodriguez, Julia, Simon, Paul H. G., Mandato, Craig, Nilsson, Tommy, Bergeron, John J. M.

“…Discovered in 1909 by Retzius and described mainly by morphology, the cytoplasmic droplet of sperm (renamed here the Hermes body) is conserved among all…”
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Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction by Bergeron, John J.M, Di Guglielmo, Gianni M, Dahan, Sophie, Dominguez, Michel, Posner, Barry I

“…Epidermal growth factor (EGF) and insulin receptor tyrosine kinases (RTKs) exemplify how receptor location is coupled to signal transduction. Extracellular…”
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Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death by Bergeron, John J.M., Au, Catherine E., Thomas, David Y., Hermo, Louis

“…GOLPH3 is the first example of a Golgi resident oncogene protein. It was independently identified in multiple screens; first in proteomic-based screens as a…”
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Proteomics of organelles and large cellular structures by Yates III, John R, Gilchrist, Annalyn, Howell, Kathryn E, Bergeron, John J. M

“…The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular…”
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Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system by Pollock, Stephanie, Kozlov, Guennadi, Pelletier, Marc-François, Trempe, Jean-François, Jansen, Gregor, Sitnikov, Dimitri, Bergeron, John JM, Gehring, Kalle, Ekiel, Irena, Thomas, David Y

“…Calnexin and ERp57 act cooperatively to ensure a proper folding of proteins in the endoplasmic reticulum (ER). Calnexin contains two domains: a lectin domain…”
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Quantitative Proteomics Analysis of the Secretory Pathway by Gilchrist, Annalyn, Au, Catherine E., Hiding, Johan, Bell, Alexander W., Fernandez-Rodriguez, Julia, Lesimple, Souad, Nagaya, Hisao, Roy, Line, Gosline, Sara J.C., Hallett, Michael, Paiement, Jacques, Kearney, Robert E., Nilsson, Tommy, Bergeron, John J.M.

“…We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and…”
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Expression, sorting, and segregation of Golgi proteins during germ cell differentiation in the testis by Au, Catherine E, Hermo, Louis, Byrne, Elliot, Smirle, Jeffrey, Fazel, Ali, Simon, Paul H G, Kearney, Robert E, Cameron, Pamela H, Smith, Charles E, Vali, Hojatollah, Fernandez-Rodriguez, Julia, Ma, Kewei, Nilsson, Tommy, Bergeron, John J M

“…The molecular basis of changes in structure, cellular location, and function of the Golgi apparatus during male germ cell differentiation is unknown. To deduce…”
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Tandem MS Analysis of Brain Clathrin-Coated Vesicles Reveals Their Critical Involvement in Synaptic Vesicle Recycling by Blondeau, Francois, Ritter, Brigitte, Allaire, Patrick D, Wasiak, Sylwia, Girard, Martine, Hussain, Natasha K, Angers, Annie, Legendre-Guillemin, Valerie, Roy, Line, Boismenu, Daniel, Kearney, Robert E, Bell, Alexander W, Bergeron, John J M, McPherson, Peter S

“…Tandem MS has identified 209 proteins of clathrin-coated vesicles (CCVs) isolated from rat brain. An overwhelming abundance of peptides were assigned to the…”
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Methods for peptide identification by spectral comparison by Liu, Jian, Bell, Alexander W, Bergeron, John J M, Yanofsky, Corey M, Carrillo, Brian, Beaudrie, Christian E H, Kearney, Robert E

“…Tandem mass spectrometry followed by database search is currently the predominant technology for peptide sequencing in shotgun proteomics experiments. Most…”
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Brain-specific Proteins Decline in the Cerebrospinal Fluid of Humans with Huntington Disease by Fang, Qiaojun, Strand, Andrew, Law, Wendy, Faca, Vitor M., Fitzgibbon, Matthew P., Hamel, Nathalie, Houle, Benoit, Liu, Xin, May, Damon H., Poschmann, Gereon, Roy, Line, Stuühler, Kai, Ying, Wantao, Zhang, Jiyang, Zheng, Zhaobin, Bergeron, John J.M., Hanash, Sam, He, Fuchu, Leavitt, Blair R., Meyer, Helmut E., Qian, Xiaohong, McIntosh, Martin W.

“…We integrated five sets of proteomics data profiling the constituents of cerebrospinal fluid (CSF) derived from Huntington disease (HD)-affected and…”
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Proteomics Impact on Cell Biology to Resolve Cell Structure and Function by Bergeron, John J.M.

“…The acceleration of advances in proteomics has enabled integration with imaging at the EM and light microscopy levels, cryo-EM of protein structures, and…”
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N‐glycosylation mediated folding and quality control in serine proteases of the hepsin family by Bergeron, John J. M., Thomas, David Y.

“…N‐linked glycans are specifically attached to asparagine residues in a N‐X‐S/T motif of secretory pathway glycoproteins. N‐glycosylation of newly synthesized…”
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Protein quality control in the ER: The recognition of misfolded proteins by Määttänen, Pekka, Gehring, Kalle, Bergeron, John J.M., Thomas, David Y.

“…The mechanism, in molecular terms of protein quality control, specifically of how the cell recognizes and discriminates misfolded proteins, remains a…”
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Erp1p and Erp2p, partners for Emp24p and Erv25p in a yeast p24 complex by Marzioch, M, Henthorn, D C, Herrmann, J M, Wilson, R, Thomas, D Y, Bergeron, J J, Solari, R C, Rowley, A

“…Six new members of the yeast p24 family have been identified and characterized. These six genes, named ERP1-ERP6 (for Emp24p- and Erv25p-related proteins) are…”
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organelle proteomic method to study neurotransmission-related proteins, applied to a neurodevelopmental model of schizophrenia by Vercauteren, Freya G.G, Flores, Gonzalo, Ma, Weiya, Chabot, Jean-Guy, Geenen, Lieve, Clerens, Stefan, Fazel, Ali, Bergeron, John J.M, Srivastava, Lalit K, Arckens, Lutgarde, Quirion, Rémi

“…Limited information is currently available on molecular events that underlie schizophrenia-like behaviors in animal models. Accordingly, we developed an…”
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Peptides you can count on by Bergeron, John JM, Hallett, Michael

“…Information on how adjusting for proteotypic peptides offers a way forward for quantitative proteomics is presented. Mallick et al and Lu et al report methods…”
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The protein microscope: incorporating mass spectrometry into cell biology by Bell, Alexander W, Nilsson, Tommy, Kearney, Robert E, Bergeron, John J M

“…Mass spectrometry has come into its own as an extremely powerful tool for the study of whole proteomes. So why are not more cell biologists embracing it with…”
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Sorting out glycosylation enzymes in the Golgi apparatus by Nilsson, Tommy, Au, Catherine E., Bergeron, John J.M.

“…The study of glycosylation and glycosylation enzymes has been instrumental for the advancement of Cell Biology. After Neutra and Leblond showed that the Golgi…”
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