Search Results - "Berger F."

The emerging clinical relevance of genomics in cancer medicine by Berger, Michael F., Mardis, Elaine R.

“…The combination of next-generation sequencing and advanced computational data analysis approaches has revolutionized our understanding of the genomic…”
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Addressing uncertainty and bias in land use, land use change, and forestry greenhouse gas inventories by McGlynn, Emily, Li, Serena, F. Berger, Michael, Amend, Meredith, L. Harper, Kandice

“…National greenhouse gas inventories (NGHGIs) will play an increasingly important role in tracking country progress against United Nations (UN) Paris Agreement…”
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Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis by Nissen, Steven E, Yeomans, Neville D, Solomon, Daniel H, Lüscher, Thomas F, Libby, Peter, Husni, M. Elaine, Graham, David Y, Borer, Jeffrey S, Wisniewski, Lisa M, Wolski, Katherine E, Wang, Qiuqing, Menon, Venu, Ruschitzka, Frank, Gaffney, Michael, Beckerman, Bruce, Berger, Manuela F, Bao, Weihang, Lincoff, A. Michael

“…This randomized trial involving patients with osteoarthritis or rheumatoid arthritis who were at increased cardiovascular risk showed the noninferiority of…”
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Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers by Landa, Iñigo, Ibrahimpasic, Tihana, Boucai, Laura, Sinha, Rileen, Knauf, Jeffrey A, Shah, Ronak H, Dogan, Snjezana, Ricarte-Filho, Julio C, Krishnamoorthy, Gnana P, Xu, Bin, Schultz, Nikolaus, Berger, Michael F, Sander, Chris, Taylor, Barry S, Ghossein, Ronald, Ganly, Ian, Fagin, James A

“…Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) are rare and frequently lethal tumors that so far have not been subjected to…”
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Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies by Harding, James J, Nandakumar, Subhiksha, Armenia, Joshua, Khalil, Danny N, Albano, Melanie, Ly, Michele, Shia, Jinru, Hechtman, Jaclyn F, Kundra, Ritika, El Dika, Imane, Do, Richard K, Sun, Yichao, Kingham, T Peter, D'Angelica, Michael I, Berger, Michael F, Hyman, David M, Jarnagin, William, Klimstra, David S, Janjigian, Yelena Y, Solit, David B, Schultz, Nikolaus, Abou-Alfa, Ghassan K

“…Prior molecular profiling of hepatocellular carcinoma (HCC) has identified actionable findings that may have a role in guiding therapeutic decision-making and…”
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Alterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers by Teo, Min Yuen, Seier, Kenneth, Ostrovnaya, Irina, Regazzi, Ashley M, Kania, Brooke E, Moran, Meredith M, Cipolla, Catharine K, Bluth, Mark J, Chaim, Joshua, Al-Ahmadie, Hikmat, Snyder, Alexandra, Carlo, Maria I, Solit, David B, Berger, Michael F, Funt, Samuel, Wolchok, Jedd D, Iyer, Gopa, Bajorin, Dean F, Callahan, Margaret K, Rosenberg, Jonathan E

“…Purpose Alterations in DNA damage response and repair (DDR) genes are associated with increased mutation load and improved clinical outcomes in…”
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Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention by Lowery, Maeve A, Ptashkin, Ryan, Jordan, Emmet, Berger, Michael F, Zehir, Ahmet, Capanu, Marinela, Kemeny, Nancy E, O'Reilly, Eileen M, El-Dika, Imane, Jarnagin, William R, Harding, James J, D'Angelica, Michael I, Cercek, Andrea, Hechtman, Jaclyn F, Solit, David B, Schultz, Nikolaus, Hyman, David M, Klimstra, David S, Saltz, Leonard B, Abou-Alfa, Ghassan K

“…Various genetic driver aberrations have been identified among distinct anatomic and clinical subtypes of intrahepatic and extrahepatic cholangiocarcinoma, and…”
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Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors by Bulyk, Martha L, Berger, Michael F

“…Protein-binding microarray (PBM) technology provides a rapid, high-throughput means of characterizing the in vitro DNA-binding specificities of transcription…”
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Next-generation Sequencing of Nonmuscle Invasive Bladder Cancer Reveals Potential Biomarkers and Rational Therapeutic Targets by Pietzak, Eugene J, Bagrodia, Aditya, Cha, Eugene K, Drill, Esther N, Iyer, Gopa, Isharwal, Sumit, Ostrovnaya, Irina, Baez, Priscilla, Li, Qiang, Berger, Michael F, Zehir, Ahmet, Schultz, Nikolaus, Rosenberg, Jonathan E, Bajorin, Dean F, Dalbagni, Guido, Al-Ahmadie, Hikmat, Solit, David B, Bochner, Bernard H

“…Abstract Background Molecular characterization of nonmuscle invasive bladder cancer (NMIBC) may provide a biologic rationale for treatment response and novel…”
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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer by Yaeger, Rona, Chatila, Walid K., Lipsyc, Marla D., Hechtman, Jaclyn F., Cercek, Andrea, Sanchez-Vega, Francisco, Jayakumaran, Gowtham, Middha, Sumit, Zehir, Ahmet, Donoghue, Mark T.A., You, Daoqi, Viale, Agnes, Kemeny, Nancy, Segal, Neil H., Stadler, Zsofia K., Varghese, Anna M., Kundra, Ritika, Gao, Jianjiong, Syed, Aijazuddin, Hyman, David M., Vakiani, Efsevia, Rosen, Neal, Taylor, Barry S., Ladanyi, Marc, Berger, Michael F., Solit, David B., Shia, Jinru, Saltz, Leonard, Schultz, Nikolaus

“…Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood. We performed…”
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Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing by Frampton, Garrett M, Fichtenholtz, Alex, Otto, Geoff A, Wang, Kai, Downing, Sean R, He, Jie, Schnall-Levin, Michael, White, Jared, Sanford, Eric M, An, Peter, Sun, James, Juhn, Frank, Brennan, Kristina, Iwanik, Kiel, Maillet, Ashley, Buell, Jamie, White, Emily, Zhao, Mandy, Balasubramanian, Sohail, Terzic, Selmira, Richards, Tina, Banning, Vera, Garcia, Lazaro, Mahoney, Kristen, Zwirko, Zac, Donahue, Amy, Beltran, Himisha, Mosquera, Juan Miguel, Rubin, Mark A, Dogan, Snjezana, Hedvat, Cyrus V, Berger, Michael F, Pusztai, Lajos, Lechner, Matthias, Boshoff, Chris, Jarosz, Mirna, Vietz, Christine, Parker, Alex, Miller, Vincent A, Ross, Jeffrey S, Curran, John, Cronin, Maureen T, Stephens, Philip J, Lipson, Doron, Yelensky, Roman

“…Clinical tests that rely on next-generation sequencing to evaluate large numbers of cancer genes can be validated using pooled cell lines with known mutations…”
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Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid by Pentsova, Elena I, Shah, Ronak H, Tang, Jiabin, Boire, Adrienne, You, Daoqi, Briggs, Samuel, Omuro, Antonio, Lin, Xuling, Fleisher, Martin, Grommes, Christian, Panageas, Katherine S, Meng, Fanli, Selcuklu, S Duygu, Ogilvie, Shahiba, Distefano, Natalie, Shagabayeva, Larisa, Rosenblum, Marc, DeAngelis, Lisa M, Viale, Agnes, Mellinghoff, Ingo K, Berger, Michael F

“…Cancer spread to the central nervous system (CNS) often is diagnosed late and is unresponsive to therapy. Mechanisms of tumor dissemination and evolution…”
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Dissecting Therapeutic Resistance to RAF Inhibition in Melanoma by Tumor Genomic Profiling by WAGLE, Nikhil, EMERY, Caroline, MEYERSON, Matthew, GARRAWAY, Levi A, BERGER, Michael F, DAVIS, Matthew J, SAWYER, Allison, POCHANARD, Panisa, KEHOE, Sarah M, JOHANNESSEN, Cory M, MACCONAILL, Laura E, HAHN, William C

“…A detailed understanding of the mechanisms by which tumors acquire resistance to targeted anticancer agents should speed the development of treatment…”
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Improved prediction of immune checkpoint blockade efficacy across multiple cancer types by Chowell, Diego, Yoo, Seong-Keun, Valero, Cristina, Pastore, Alessandro, Krishna, Chirag, Lee, Mark, Hoen, Douglas, Shi, Hongyu, Kelly, Daniel W., Patel, Neal, Makarov, Vladimir, Ma, Xiaoxiao, Vuong, Lynda, Sabio, Erich Y., Weiss, Kate, Kuo, Fengshen, Lenz, Tobias L., Samstein, Robert M., Riaz, Nadeem, Adusumilli, Prasad S., Balachandran, Vinod P., Plitas, George, Ari Hakimi, A., Abdel-Wahab, Omar, Shoushtari, Alexander N., Postow, Michael A., Motzer, Robert J., Ladanyi, Marc, Zehir, Ahmet, Berger, Michael F., Gönen, Mithat, Morris, Luc G. T., Weinhold, Nils, Chan, Timothy A.

“…Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB) treatment, but current decision-making procedures have limited accuracy. In…”
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Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets by Rekhtman, Natasha, Pietanza, Maria C, Hellmann, Matthew D, Naidoo, Jarushka, Arora, Arshi, Won, Helen, Halpenny, Darragh F, Wang, Hangjun, Tian, Shaozhou K, Litvak, Anya M, Paik, Paul K, Drilon, Alexander E, Socci, Nicholas, Poirier, John T, Shen, Ronglai, Berger, Michael F, Moreira, Andre L, Travis, William D, Rudin, Charles M, Ladanyi, Marc

“…Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a highly aggressive neoplasm, whose biologic relationship to small cell lung carcinoma (SCLC) versus…”
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Recurrent SMARCA4 mutations in small cell carcinoma of the ovary by Jelinic, Petar, Mueller, Jennifer J, Olvera, Narciso, Dao, Fanny, Scott, Sasinya N, Shah, Ronak, Gao, JianJiong, Schultz, Nikolaus, Gonen, Mithat, Soslow, Robert A, Berger, Michael F, Levine, Douglas A

“…Douglas Levine and colleagues identify recurrent inactivating mutations in the SWI/SNF complex member SMARCA4 in 12 of 12 samples of small cell carcinoma of…”
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The genetic landscape of endometrial clear cell carcinomas by DeLair, Deborah F, Burke, Kathleen A, Selenica, Pier, Lim, Raymond S, Scott, Sasinya N, Middha, Sumit, Mohanty, Abhinita S, Cheng, Donavan T, Berger, Michael F, Soslow, Robert A, Weigelt, Britta

“…Clear cell carcinoma of the endometrium is a rare type of endometrial cancer that is generally associated with an aggressive clinical behaviour. Here, we…”
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PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors by Lee, William, Teckie, Sewit, Wiesner, Thomas, Ran, Leili, Prieto Granada, Carlos N, Lin, Mingyan, Zhu, Sinan, Cao, Zhen, Liang, Yupu, Sboner, Andrea, Tap, William D, Fletcher, Jonathan A, Huberman, Kety H, Qin, Li-Xuan, Viale, Agnes, Singer, Samuel, Zheng, Deyou, Berger, Michael F, Chen, Yu, Antonescu, Cristina R, Chi, Ping

“…Ping Chi and colleagues identify recurrent inactivating mutations in the PRC2 core components EED and SUZ12 in malignant peripheral nerve sheath tumors. They…”
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Rockfall characterisation and structural protection – a review by Volkwein, A., Schellenberg, K., Labiouse, V., Agliardi, F., Berger, F., Bourrier, F., Dorren, L. K. A., Gerber, W., Jaboyedoff, M.

“…Rockfall is an extremely rapid process involving long travel distances. Due to these features, when an event occurs, the ability to take evasive action is…”
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Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma by Grommes, Christian, Tang, Sarah S., Wolfe, Julia, Kaley, Thomas J., Daras, Mariza, Pentsova, Elena I., Piotrowski, Anna F., Stone, Jacqueline, Lin, Andrew, Nolan, Craig P., Manne, Malbora, Codega, Paolo, Campos, Carl, Viale, Agnes, Thomas, Alissa A., Berger, Michael F., Hatzoglou, Vaios, Reiner, Anne S., Panageas, Katherine S., DeAngelis, Lisa M., Mellinghoff, Ingo K.

“…Ibrutinib is a first-in-class inhibitor of Bruton tyrosine kinase (BTK) and has shown single-agent activity in recurrent/refractory central nervous system…”
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