Search Results - "Berger, Steffen M."

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer by Yasinska, Inna M, Sakhnevych, Svetlana S, Pavlova, Ludmila, Teo Hansen Selnø, Anette, Teuscher Abeleira, Ana Maria, Benlaouer, Ouafa, Gonçalves Silva, Isabel, Mosimann, Marianne, Varani, Luca, Bardelli, Marco, Hussain, Rohanah, Siligardi, Giuliano, Cholewa, Dietmar, Berger, Steffen M, Gibbs, Bernhard F, Ushkaryov, Yuri A, Fasler-Kan, Elizaveta, Klenova, Elena, Sumbayev, Vadim V

“…Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the…”
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Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity by Yasinska, Inna M, Meyer, N Helge, Schlichtner, Stephanie, Hussain, Rohanah, Siligardi, Giuliano, Casely-Hayford, Maxwell, Fiedler, Walter, Wellbrock, Jasmin, Desmet, Cloe, Calzolai, Luigi, Varani, Luca, Berger, Steffen M, Raap, Ulrike, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities…”
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The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells by Gonçalves Silva, Isabel, Yasinska, Inna M., Sakhnevych, Svetlana S., Fiedler, Walter, Wellbrock, Jasmin, Bardelli, Marco, Varani, Luca, Hussain, Rohanah, Siligardi, Giuliano, Ceccone, Giacomo, Berger, Steffen M., Ushkaryov, Yuri A., Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating…”
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Cytokine Signaling in Pediatric Kidney Tumor Cell Lines WT-CLS1, WT-3ab and G-401 by Fasler-Kan, Elizaveta, Milošević, Milan, Ruggiero, Sabrina, Aliu, Nijas, Cholewa, Dietmar, Häcker, Frank-Martin, Dekany, Gabriela, Bartenstein, Andreas, Berger, Steffen M

“…Renal tumors comprise ~7% of all malignant pediatric tumors. Approximately 90% of pediatric kidney tumors comprise Wilms tumors, and the remaining 10% include…”
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L-Kynurenine participates in cancer immune evasion by downregulating hypoxic signaling in T lymphocytes by Schlichtner, Stephanie, Yasinska, Inna M., Klenova, Elena, Abooali, Maryam, Lall, Gurprit S., Berger, Steffen M., Ruggiero, Sabrina, Cholewa, Dietmar, Milošević, Milan, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…Malignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion…”
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High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells by Teo Hansen Selnø, Anette, Schlichtner, Stephanie, Yasinska, Inna M., Sakhnevych, Svetlana S., Fiedler, Walter, Wellbrock, Jasmin, Berger, Steffen M., Klenova, Elena, Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…High mobility group box 1 (HMGB1) is a non-histone protein which is predominantly localised in the cell nucleus. However, stressed, dying, injured or dead…”
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Schlichtner, Stephanie, Yasinska, Inna M, Lall, Gurprit S, Berger, Steffen M, Ruggiero, Sabrina, Cholewa, Dietmar, Aliu, Nijas, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the…”
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Activation of immune evasion machinery is a part of the process of malignant transformation of human cells by Abooali, Maryam, Yasinska, Inna M., Schlichtner, Stephanie, Ruggiero, Sabrina, Berger, Steffen M., Cholewa, Dietmar, Milošević, Milan, Bartenstein, Andreas, Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…•The biochemical mechanisms of activation of immune evasion machinery during malignant transformation of human epithelial cells are reported.•This work…”
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Cytokines Activate JAK–STAT Signaling Pathway in MG-63 Cells on Titanium and Zirconia by Mukaddam, Khaled, Ruggiero, Sabrina, Berger, Steffen M, Cholewa, Dietmar, Kühl, Sebastian, Vegh, Daniel, Payer, Michael, Bornstein, Michael M, Alhawasli, Farah, Fasler-Kan, Elizaveta

“…Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen the widespread application of zirconia implants…”
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The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells by Gonçalves Silva, Isabel, Rüegg, Laura, Gibbs, Bernhard F., Bardelli, Marco, Fruehwirth, Alexander, Varani, Luca, Berger, Steffen M., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor…”
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Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 - Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes by Schlichtner, Stephanie, Yasinska, Inna M, Ruggiero, Sabrina, Berger, Steffen M, Aliu, Nijas, Prunk, Mateja, Kos, Janko, Meyer, N Helge, Gibbs, Bernhard F, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins…”
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Chromosomal Heterogeneity of the G-401 Rhabdoid Tumor Cell Line: Unusual Partial 7p Trisomy by Fasler-Kan, Elizaveta, Aliu, Nijas, Haecker, Frank-Martin, Maltsev, Natalia, Ruggiero, Sabrina, Cholewa, Dietmar, Bartenstein, Andreas, Milošević, Milan, Berger, Steffen M.

“…Rhabdoid tumor is a very aggressive and hardly curable pediatric malignancy. It commonly starts in the kidneys but also can occur in the brain, liver, and…”
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Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis by Schlichtner, Stephanie, Meyer, N. Helge, Yasinska, Inna M., Aliu, Nijas, Berger, Steffen M., Gibbs, Bernhard F., Fasler-Kan, Elizaveta, Sumbayev, Vadim V.

“…•Galectin-9 is involved in the opsonisation of Gram-negative bacteria.•Galectin-9 promotes anti-bacterial immune defence.•Galectin-9 suppresses cytotoxic T…”
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Health-related quality of life after conservatively and surgically-treated paediatric proximal humeral fractures by Liebs, Thoralf R., Rompen, Ingmar, Berger, Steffen M., Ziebarth, Kai

“…Abstract Purpose The health-related quality of life (HRQoL) after conservatively versus surgically treated paediatric proximal humeral fractures is poorly…”
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Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells by Selnø, Anette Teo Hansen, Schlichtner, Stephanie, Yasinska, Inna M, Sakhnevych, Svetlana S, Fiedler, Walter, Wellbrock, Jasmin, Klenova, Elena, Pavlova, Ludmila, Gibbs, Bernhard F, Degen, Martin, Schnyder, Isabelle, Aliu, Nijas, Berger, Steffen M, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Galectin-9 is one of the key proteins employed by a variety of human malignancies to suppress anti-cancer activities of cytotoxic lymphoid cells and thus…”
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Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates by Yasinska, Inna M, Ceccone, Giacomo, Ojea-Jimenez, Isaac, Ponti, Jessica, Hussain, Rohanah, Siligardi, Giuliano, Berger, Steffen M, Fasler-Kan, Elizaveta, Bardelli, Marco, Varani, Luca, Fiedler, Walter, Wellbrock, Jasmin, Raap, Ulrike, Gibbs, Bernhard F, Calzolai, Luigi, Sumbayev, Vadim V

“…In this study we used 5 nm gold nanoparticles as delivery platforms to target cancer cells expressing the immune receptor Tim-3 using single chain antibodies…”
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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity by Gibbs, Bernhard F, Gonçalves Silva, Isabel, Prokhorov, Alexandr, Abooali, Maryam, Yasinska, Inna M, Casely-Hayford, Maxwell A, Berger, Steffen M, Fasler-Kan, Elizaveta, Sumbayev, Vadim V

“…Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a…”
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Unique Presentation of Hematometrocolpos Mimicking Cauda Equina Syndrome: Severe Back Pain and Urinary Incontinence in an Adolescent Girl by Löllgen, Ruth Mari, MD, Sabo, Jan, MD, Mettler, Anja, MD, Liniger, Benjamin, MD, Berger, Steffen, MD

“…Abstract Background Imperforate hymen with hematometrocolpos in adolescent females is a rare pediatric condition. Classical presentation includes abdominal…”
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Clostridium perfringens and necrotizing enterocolitis by Schlapbach, Luregn J., MD, Ahrens, Olaf, MD, Klimek, Peter, MD, Berger, Steffen, MD, Kessler, Ulf, MD

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