Search Results - "Berger, Scott B"

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death by Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A, Berger, Scott B, Gough, Peter J, Bertin, John, Proulx, Megan M, Goguen, Jon D, Kayagaki, Nobuhiko, Fitzgerald, Katherine A, Lien, Egil

“…Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via…”
Get full text

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice by Berger, Scott B, Kasparcova, Viera, Hoffman, Sandy, Swift, Barb, Dare, Lauren, Schaeffer, Michelle, Capriotti, Carol, Cook, Michael, Finger, Joshua, Hughes-Earle, Angela, Harris, Philip A, Kaiser, William J, Mocarski, Edward S, Bertin, John, Gough, Peter J

“…RIP1 (RIPK1) kinase is a key regulator of TNF-induced NF-κB activation, apoptosis, and necroptosis through its kinase and scaffolding activities. Dissecting…”
Get full text

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity by Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

“…Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease…”
Get full text

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition by Kaiser, William J., Daley-Bauer, Lisa P., Thapa, Roshan J., Mandal, Pratyusha, Berger, Scott B., Huang, Chunzi, Sundararajan, Aarthi, Guo, Hongyan, Roback, Linda, Speck, Samuel H., Bertin, John, Gough, Peter J., Balachandran, Siddharth, Mocarski, Edward S.

“…The pronecrotic kinase, receptor interacting protein (RIP1, also called RIPK1) mediates programmed necrosis and, together with its partner, RIP3 (RIPK3),…”
Get full text

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense by Peterson, Lance W, Philip, Naomi H, DeLaney, Alexandra, Wynosky-Dolfi, Meghan A, Asklof, Kendra, Gray, Falon, Choa, Ruth, Bjanes, Elisabet, Buza, Elisabeth L, Hu, Baofeng, Dillon, Christopher P, Green, Douglas R, Berger, Scott B, Gough, Peter J, Bertin, John, Brodsky, Igor E

“…Many pathogens deliver virulence factors or effectors into host cells in order to evade host defenses and establish infection. Although such effector proteins…”
Get full text

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses by Yu, Jong W, Hoffman, Sandy, Beal, Allison M, Dykon, Angela, Ringenberg, Michael A, Hughes, Anna C, Dare, Lauren, Anderson, Amber D, Finger, Joshua, Kasparcova, Viera, Rickard, David, Berger, Scott B, Ramanjulu, Joshi, Emery, John G, Gough, Peter J, Bertin, John, Foley, Kevin P

“…CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and other pathways. Previous studies have suggested that as part of this…”
Get full text

Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer by Harris, Philip A, Marinis, Jill M, Lich, John D, Berger, Scott B, Chirala, Anirudh, Cox, Julie A, Eidam, Patrick M, Finger, Joshua N, Gough, Peter J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Leister, Lara K, Mahajan, Mukesh K, Miller, George, Nagilla, Rakesh, Ouellette, Michael T, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Sun, Helen H, Thorpe, James H, Totoritis, Rachel D, Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W

“…RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including…”
Get full text

GITR engagement preferentially enhances proliferation of functionally competent CD4+CD25+FoxP3+ regulatory T cells by Liao, Gongxian, Nayak, Sushrusha, Regueiro, Jose R., Berger, Scott B., Detre, Cynthia, Romero, Xavier, de Waal Malefyt, Rene, Chatila, Talal A., Herzog, Roland W., Terhorst, Cox

“…Naturally occurring regulatory T cells (Treg) express high levels of glucocorticoid-induced tumour necrosis factor receptor (GITR). However, studies of the…”
Get full text

A novel isoform of the Ly108 gene ameliorates murine lupus by Keszei, Marton, Detre, Cynthia, Rietdijk, Svend T, Muñoz, Pilar, Romero, Xavier, Berger, Scott B, Calpe, Silvia, Liao, Gongxian, Castro, Wilson, Julien, Aimee, Wu, Ying-Yu, Shin, Dong-Mi, Sancho, Jaime, Zubiaur, Mercedes, Morse, 3rd, Herbert C, Morel, Laurence, Engel, Pablo, Wang, Ninghai, Terhorst, Cox

“…Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic…”
Get full text

Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages by Wang, Guoxing, Abadía-Molina, Ana C, Berger, Scott B, Romero, Xavier, O'Keeffe, Michael S, Rojas-Barros, Domingo I, Aleman, Marta, Liao, Gongxian, Maganto-García, Elena, Fresno, Manuel, Wang, Ninghai, Detre, Cynthia, Terhorst, Cox

“…Slamf8 (CD353) is a cell surface receptor that is expressed upon activation of macrophages (MΦs) by IFN-γ or bacteria. In this article, we report that a very…”
Get full text

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis by Takahashi, Nozomi, Vereecke, Lars, Bertrand, Mathieu J. M., Duprez, Linde, Berger, Scott B., Divert, Tatyana, Gonçalves, Amanda, Sze, Mozes, Gilbert, Barbara, Kourula, Stephanie, Goossens, Vera, Lefebvre, Sylvie, Günther, Claudia, Becker, Christoph, Bertin, John, Gough, Peter J., Declercq, Wim, van Loo, Geert, Vandenabeele, Peter

“…This study provides evidence for a critical role of RIPK1 in suppressing caspase-8-mediated cell death and maintaining intestinal homeostasis independently of…”
Get full text

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases by Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

“…RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated…”
Get full text

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors by Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J

“…The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence…”
Get full text

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock by Mandal, Pratyusha, Feng, Yanjun, Lyons, John D., Berger, Scott B., Otani, Shunsuke, DeLaney, Alexandra, Tharp, Gregory K., Maner-Smith, Kristal, Burd, Eileen M., Schaeffer, Michelle, Hoffman, Sandra, Capriotti, Carol, Roback, Linda, Young, Cedrick B., Liang, Zhe, Ortlund, Eric A., DiPaolo, Nelson C., Bosinger, Steven, Bertin, John, Gough, Peter J., Brodsky, Igor E., Coopersmith, Craig M., Shayakhmetov, Dmitry M., Mocarski, Edward S.

“…The execution of shock following high dose E. coli lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to…”
Get full text

T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer by Washburn, Michael L, Wang, Zhang, Walton, Andrew H, Goedegebuure, S Peter, Figueroa, David J, Van Horn, Stephanie, Grossman, Julie, Remlinger, Katja, Madsen, Heather, Brown, James, Srinivasan, Roopa, Wolf, Amaya I, Berger, Scott B, Yi, Victoria N, Hawkins, William G, Fields, Ryan C, Hotchkiss, Richard S

“…Sepsis is characterized as life-threatening organ dysfunction caused by a dysregulated host immune response to infection. The purpose of this investigation was…”
Get full text

Age‐associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells by Garcia, Gonzalo G., Berger, Scott B., Sadighi Akha, Amir A. A., Miller, Richard A.

“…We have recently shown that treatment of T cells from aged mice with an endopeptidase specific for O‐linked glycoproteins can restore synapse formation and…”
Get full text

The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase by Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

“…RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1…”
Get full text

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages by Berger, Scott B, Terhorst, Cox, Romero, Xavier, Ma, Chunyan, Wang, Guoxing, Faubion, William A, Liao, Gongxian, Compeer, Ewoud, Keszei, Marton, Rameh, Lucia, Wang, Ninghai, Boes, Marianne, Regueiro, Jose R, Reinecker, Hans-Christian

“…SLAM is best known for its homotypic costimulatory molecule functions. Terhorst and colleagues now demonstrate that it also acts as a sensor for Gram-negative…”
Get full text

The SLAM and SAP gene families control innate and adaptive immune responses by Calpe, Silvia, Wang, Ninghai, Romero, Xavier, Berger, Scott B, Lanyi, Arpad, Engel, Pablo, Terhorst, Cox

“…The nine SLAM-family genes, SLAMF1-9, a subfamily of the immunoglobulin superfamily, encode differentially expressed cell-surface receptors of hematopoietic…”
Get more information

Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases by Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W

“…RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including…”
Get full text