Search Results - "Berger, James M"

Mechanisms for initiating cellular DNA replication by Bleichert, Franziska, Botchan, Michael R., Berger, James M.

“…Cellular DNA replication factories depend on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping the parental DNA helix. Replicative…”
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Crystal structure of the eukaryotic origin recognition complex by Bleichert, Franziska, Botchan, Michael R., Berger, James M.

“…Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC)…”
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Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II by Lee, Joyce H, Berger, James M

“…Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes…”
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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling by Kranzusch, Philip J., Wilson, Stephen C., Lee, Amy S.Y., Berger, James M., Doudna, Jennifer A., Vance, Russell E.

“…In humans, the cGAS-STING immunity pathway signals in response to cytosolic DNA via 2′,3′ cGAMP, a cyclic dinucleotide (CDN) second messenger containing mixed…”
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Mechanisms and regulation of DNA replication initiation in eukaryotes by Parker, Matthew W, Botchan, Michael R, Berger, James M

“…Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins)…”
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All tangled up: how cells direct, manage and exploit topoisomerase function by Vos, Seychelle M., Tretter, Elsa M., Schmidt, Bryan H., Berger, James M.

“…Key Points Topoisomerases are classified into several families, namely, types IA, IB, IC, IIA and IIB. These families have different cellular roles and…”
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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis by Blower, Tim R., Williamson, Benjamin H., Kerns, Robert J., Berger, James M.

“…Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and in 2013 accounted for 1.5 million deaths. Fluoroquinolone antibacterials,…”
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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity by Kranzusch, Philip J., Lee, Amy Si-Ying, Berger, James M., Doudna, Jennifer A.

“…Innate immune recognition of foreign nucleic acids induces protective interferon responses. Detection of cytosolic DNA triggers downstream immune signaling…”
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Mechanisms for initiating cellular DNA replication by Costa, Alessandro, Hood, Iris V, Berger, James M

“…The initiation of DNA replication represents a committing step to cell proliferation. Appropriate replication onset depends on multiprotein complexes that help…”
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Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases by Thomsen, Nathan D., Berger, James M.

“…Hexameric helicases couple ATP hydrolysis to processive separation of nucleic acid duplexes, a process critical for gene expression, DNA replication, and…”
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DNA stretching by bacterial initiators promotes replication origin opening by Duderstadt, Karl E., Chuang, Kevin, Berger, James M.

“…Many replication initiators form higher-order oligomers that process host replication origins to promote replisome formation. In addition to dedicated…”
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The structural basis for MCM2-7 helicase activation by GINS and Cdc45 by Botchan, Michael R, Berger, James M, Costa, Alessandro, Ilves, Ivar, Tamberg, Nele, Petojevic, Tatjana, Nogales, Eva

“…In eukaryotes, DNA replication depends on loading the ring-shaped helicase, Mcm2–7 onto double-stranded DNA and subsequent activation by GINS–Cdc45. Using…”
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DNA topoisomerases: harnessing and constraining energy to govern chromosome topology by Schoeffler, Allyn J, Berger, James M

“…DNA topoisomerases are a diverse set of essential enzymes responsible for maintaining chromosomes in an appropriate topological state. Although they vary…”
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Structural basis for gate-DNA recognition and bending by type IIA topoisomerases by Berger, James M, Dong, Ken C

“…Type II topoisomerases disentangle DNA to facilitate chromosome segregation, and represent a major class of therapeutic targets. Although these enzymes have…”
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DNA replication initiation: mechanisms and regulation in bacteria by Berger, James M, Mott, Melissa L

“…In all organisms, multi-subunit replicases are responsible for the accurate duplication of genetic material during cellular division. Initiator proteins…”
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Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II by Bandak, Afif F, Blower, Tim R, Nitiss, Karin C, Shah, Viraj, Nitiss, John L, Berger, James M

“…Abstract Type II topoisomerases effect topological changes in DNA by cutting a single duplex, passing a second duplex through the break, and resealing the…”
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A new class of disordered elements controls DNA replication through initiator self-assembly by Parker, Matthew W, Bell, Maren, Mir, Mustafa, Kao, Jonchee A, Darzacq, Xavier, Botchan, Michael R, Berger, James M

“…The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC),…”
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Mechanism for the Regulated Control of Bacterial Transcription Termination by a Universal Adaptor Protein by Lawson, Michael R., Ma, Wen, Bellecourt, Michael J., Artsimovitch, Irina, Martin, Andreas, Landick, Robert, Schulten, Klaus, Berger, James M.

“…NusG/Spt5 proteins are the only transcription factors utilized by all cellular organisms. In enterobacteria, NusG antagonizes the transcription termination…”
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An Atypical AAA+ ATPase Assembly Controls Efficient Transposition through DNA Remodeling and Transposase Recruitment by Arias-Palomo, Ernesto, Berger, James M.

“…Transposons are ubiquitous genetic elements that drive genome rearrangements, evolution, and the spread of infectious disease and drug-resistance. Many…”
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Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase by Aldred, Katie J., Blower, Tim R., Kerns, Robert J., Berger, James M., Osheroff, Neil

“…Mycobacterium tuberculosis is a significant source of global morbidity and mortality. Moxifloxacin and other fluoroquinolones are important therapeutic agents…”
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