Search Results - "Berger, Ina M"

The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation by Just, Steffen, Hirth, Sofia, Berger, Ina M., Fishman, Mark C., Rottbauer, Wolfgang

“…In search for novel key regulators of cardiac valve formation, we isolated the zebrafish cardiac valve mutant ping pong (png). We find that an insertional…”
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Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish by Just, Steffen, Raphel, Linda, Berger, Ina M, Bühler, Anja, Keßler, Mirjam, Rottbauer, Wolfgang

“…The molecular mechanisms that regulate cardiomyocyte proliferation during embryonic heart growth are not completely deciphered yet. In a forward genetic…”
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The myosin-interacting protein SMYD1 is essential for sarcomere organization by Just, Steffen, Meder, Benjamin, Berger, Ina M, Etard, Christelle, Trano, Nicole, Patzel, Eva, Hassel, David, Marquart, Sabine, Dahme, Tillman, Vogel, Britta, Fishman, Mark C, Katus, Hugo A, Strähle, Uwe, Rottbauer, Wolfgang

“…Assembly, maintenance and renewal of sarcomeres require highly organized and balanced folding, transport, modification and degradation of sarcomeric proteins…”
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Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish by Keßler, Mirjam, Berger, Ina M., Just, Steffen, Rottbauer, Wolfgang

“…The genetic underpinnings of heart rate regulation are only poorly understood. In search for genetic regulators of cardiac pacemaker activity, we isolated in a…”
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Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia by Hoffmann, Sandra, Berger, Ina M., Glaser, Anne, Bacon, Claire, Li, Li, Gretz, Norbert, Steinbeisser, Herbert, Rottbauer, Wolfgang, Just, Steffen, Rappold, Gudrun

“…The heart’s rhythm is initiated and regulated by a group of specialized cells in the sinoatrial node (SAN), the primary pacemaker of the heart. Abnormalities…”
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Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish by Segert, Julia, Schneider, Isabelle, Berger, Ina M., Rottbauer, Wolfgang, Just, Steffen

“…The molecular mechanism essential for the formation of heart valves involves complex interactions of signaling molecules and transcription factors. The…”
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Overlapping and Opposing Functions of G Protein-coupled Receptor Kinase 2 (GRK2) and GRK5 during Heart Development by Philipp, Melanie, Berger, Ina M., Just, Steffen, Caron, Marc G.

“…G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5) are fundamental regulators of cardiac performance in adults but are less well characterized for their…”
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Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish by Pott, Alexander, Bock, Sarah, Berger, Ina M., Frese, Karen, Dahme, Tillman, Keßler, Mirjam, Rinné, Susanne, Decher, Niels, Just, Steffen, Rottbauer, Wolfgang

“…The genetic underpinnings that orchestrate the vertebrate heart rate are not fully understood yet, but of high clinical importance, since diseases of cardiac…”
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Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response by Hein, Kerstin, Mittler, Gerhard, Cizelsky, Wiebke, Kühl, Michael, Ferrante, Francesca, Liefke, Robert, Berger, Ina M, Just, Steffen, Sträng, J Eric, Kestler, Hans A, Oswald, Franz, Borggrefe, Tilman

“…Physiologically, Notch signal transduction plays a pivotal role in differentiation; pathologically, Notch signaling contributes to the development of cancer…”
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F-Box and Leucine-Rich Repeat Protein 22 Is a Cardiac-Enriched F-Box Protein That Regulates Sarcomeric Protein Turnover and Is Essential for Maintenance of Contractile Function In Vivo by Spaich, Sebastian, Will, Rainer D, Just, Steffen, Spaich, Saskia, Kuhn, Christian, Frank, Derk, Berger, Ina M, Wiemann, Stefan, Korn, Bernhard, Koegl, Manfred, Backs, Johannes, Katus, Hugo A, Rottbauer, Wolfgang, Frey, Norbert

“…RATIONALE:The emerging role of the ubiquitin–proteasome system in cardiomyocyte function and homeostasis implies the necessity of tight regulation of protein…”
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Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation by Hoffmann, Sandra, Clauss, Sebastian, Berger, Ina M., Weiß, Birgit, Montalbano, Antonino, Röth, Ralph, Bucher, Madeline, Klier, Ina, Wakili, Reza, Seitz, Hervé, Schulze-Bahr, Eric, Katus, Hugo A., Flachsbart, Friederike, Nebel, Almut, Guenther, Sabina PW, Bagaev, Erik, Rottbauer, Wolfgang, Kääb, Stefan, Just, Steffen, Rappold, Gudrun A.

“…Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription…”
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Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity by JUST, Steffen, BERGER, Ina M, ROTTBAUER, Wolfgang, MEDER, Benjamin, BACKS, Johannes, KELLER, Andreas, MARQUART, Sabine, FRESE, Karen, PATZEL, Eva, RAUCH, Gerd-Jörg, KATUS, Hugo A

“…The molecular mechanisms that guide heart valve formation are not well understood. However, elucidation of the genetic basis of congenital heart disease is one…”
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Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish by Meder, Benjamin, Scholz, Eberhard P., Hassel, David, Wolff, Christoph, Just, Steffen, Berger, Ina M., Patzel, Eva, Karle, Christoph, Katus, Hugo A., Rottbauer, Wolfgang

“…► Embryonic and adult breakdance zebrafish mutants are a valuable model for human Long-QT syndrome. ► The breakdance mutation (zERG I59S) disrupts ERG protein…”
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The myosin-interacting protein SMYD1 is essential for sarcomere organization by Just, Steffen, Meder, Benjamin, Berger, Ina M., Etard, Christelle, Trano, Nicole, Patzel, Eva, Hassel, David, Marquart, Sabine, Dahme, Tillman, Vogel, Britta, Fishman, Mark C., Katus, Hugo A., Strähle, Uwe, Rottbauer, Wolfgang

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