Search Results - "Bergen, Ingrid"

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome by Kool, Mirjam, Petrilli, Virginie, De Smedt, Thibaut, Rolaz, Aline, Hammad, Hamida, van Nimwegen, Menno, Bergen, Ingrid M, Castillo, Rosa, Lambrecht, Bart N, Tschopp, Jurg

“…Adjuvants are vaccine additives that stimulate the immune system without having any specific antigenic effect of itself. In this study we show that alum…”
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Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice by GeurtsvanKessel, Corine H, Willart, Monique A M, Bergen, Ingrid M, van Rijt, Leonie S, Muskens, Femke, Elewaut, Dirk, Osterhaus, Albert D M E, Hendriks, Rudi, Rimmelzwaan, Guus F, Lambrecht, Bart N

“…Tertiary lymphoid organs (TLOs) are organized aggregates of B and T cells formed in postembryonic life in response to chronic immune responses to infectious…”
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Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations by van der Ploeg, Esmee K., Krabbendam, Lisette, Vroman, Heleen, van Nimwegen, Menno, de Bruijn, Marjolein J. W., de Boer, Geertje M., Bergen, Ingrid M., Kool, Mirjam, Tramper-Standers, Gerdien A., Braunstahl, Gert-Jan, Huylebroeck, Danny, Hendriks, Rudi W., Stadhouders, Ralph

“…CD4 + T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel chronic airway inflammation in…”
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The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus by Ribeiro de Almeida, Claudia, Stadhouders, Ralph, de Bruijn, Marjolein J.W., Bergen, Ingrid M., Thongjuea, Supat, Lenhard, Boris, van IJcken, Wilfred, Grosveld, Frank, Galjart, Niels, Soler, Eric, Hendriks, Rudi W.

“…Regulation of immunoglobulin (Ig) V(D)J gene rearrangement is dependent on higher-order chromatin organization. Here, we studied the in vivo function of the…”
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Central Role of Dendritic Cells in Pulmonary Arterial Hypertension in Human and Mice by van Uden, Denise, Koudstaal, Thomas, van Hulst, Jennifer A C, Bergen, Ingrid M, Gootjes, Chelsea, Morrell, Nicholas W, van Loo, Geert, von der Thüsen, Jan H, van den Bosch, Thierry P P, Ghigna, Maria-Rosa, Perros, Frédéric, Montani, David, Kool, Mirjam, Boomars, Karin A, Hendriks, Rudi W

“…The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but evidence is accumulating that immune dysfunction plays a…”
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Increased proportions of circulating PD-1 + CD4 + memory T cells and PD-1 + regulatory T cells associate with good response to prednisone in pulmonary sarcoidosis by Miedema, Jelle R, de Jong, Lieke J, Kahlmann, Vivienne, Bergen, Ingrid M, Broos, Caroline E, Wijsenbeek, Marlies S, Hendriks, Rudi W, Corneth, Odilia B J

“…The treatment response to corticosteroids in patients with sarcoidosis is highly variable. CD4 T cells are central in sarcoid pathogenesis and their phenotype…”
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TNF-α–induced protein 3 levels in lung dendritic cells instruct TH2 or TH17 cell differentiation in eosinophilic or neutrophilic asthma by Vroman, Heleen, Bergen, Ingrid M., van Hulst, Jennifer A.C., van Nimwegen, Menno, van Uden, Denise, Schuijs, Martijn J., Pillai, Saravanan Y., van Loo, Geert, Hammad, Hamida, Lambrecht, Bart N., Hendriks, Rudi W., Kool, Mirjam

“…It is currently unknown why allergen exposure or environmental triggers in patients with mild-to-moderate asthma result in TH2-mediated eosinophilic…”
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T cells and ILC2s are major effector cells in influenza‐induced exacerbation of allergic airway inflammation in mice by Li, Bobby W. S., de Bruijn, Marjolein J. W., Lukkes, Melanie, Nimwegen, Menno, Bergen, Ingrid M., KleinJan, Alex, GeurtsvanKessel, Corine H., Andeweg, Arno, Rimmelzwaan, Guus F., Hendriks, Rudi W.

“…Influenza virus infection is an important cause of severe asthma exacerbations, but it remains unclear how a Th1‐mediated antiviral response triggers a…”
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Aberrant B cell receptor signaling in circulating naïve and IgA+ memory B cells from newly-diagnosed autoantibody-positive rheumatoid arthritis patients by Neys, Stefan F.H., Heutz, Judith W., van Hulst, Jennifer A.C., Vink, Madelief, Bergen, Ingrid M., de Jong, Pascal H.P., Lubberts, Erik, Hendriks, Rudi W., Corneth, Odilia B.J.

“…Altered B cell receptor (BCR) signaling has been implicated in the pathogenesis of rheumatoid arthritis (RA). Here we aimed to identify signaling aberrations…”
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Local and systemic cytokine profiles in nonsevere and severe community-acquired pneumonia by PAATS, Marthe S, BERGEN, Ingrid M, HANSELAAR, Wessel E. J. J, GROENINX VAN ZOELEN, E. Christine, HOOGSTEDEN, Henk C, HENDRIKS, Rudi W, VAN DER EERDEN, Menno M

“…Local inflammatory responses in community-acquired pneumonia (CAP) remain insufficiently elucidated, especially in patients with nonsevere CAP. In this study…”
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Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis by ten Berge, Bregje, Paats, Marthe S., Bergen, Ingrid M., van den Blink, Bernt, Hoogsteden, Henk C., Lambrecht, Bart N., Hendriks, Rudi W., KleinJan, Alex

“…Objective. Sarcoidosis is a systemic inflammatory disorder characterized by granulomas. Although the aetiology is unknown, sarcoidosis is thought to be…”
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Circulating T cells in sarcoidosis have an aberrantly activated phenotype that correlates with disease outcome by Miedema, Jelle R., de Jong, Lieke J., van Uden, Denise, Bergen, Ingrid M., Kool, Mirjam, Broos, Caroline E., Kahlmann, Vivienne, Wijsenbeek, Marlies S., Hendriks, Rudi W., Corneth, Odilia B.J.

“…Disease course in sarcoidosis is highly variable. Bronchoalveolar lavage fluid and mediastinal lymph nodes show accumulation of activated T cells with a…”
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Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress by Tindemans, Irma, van Schoonhoven, Anne, KleinJan, Alex, de Bruijn, Marjolein Jw, Lukkes, Melanie, van Nimwegen, Menno, van den Branden, Anouk, Bergen, Ingrid M, Corneth, Odilia Bj, van IJcken, Wilfred Fj, Stadhouders, Ralph, Hendriks, Rudi W

“…Allergic asthma is mediated by Th2 responses to inhaled allergens. Although previous experiments indicated that Notch signaling activates expression of the key…”
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Tnfaip3 expression in pulmonary conventional type 1 Langerin‐expressing dendritic cells regulates T helper 2‐mediated airway inflammation in mice by Vroman, Heleen, Uden, Denise, Bergen, Ingrid M., Hulst, Jennifer A. C., Lukkes, Melanie, Loo, Geert, Clausen, Björn E., Boon, Louis, Lambrecht, Bart N., Hammad, Hamida, Hendriks, Rudi W., Kool, Mirjam

“…Background Conventional type 1 dendritic cells (cDC1s) control anti‐viral and anti‐tumor immunity by inducing antigen‐specific cytotoxic CD8+ T‐cell responses…”
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DNGR1-Cre-mediated Deletion of Tnfaip3 /A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice by Koudstaal, Thomas, van Hulst, Jennifer A C, Das, Tridib, Neys, Stefan F H, Merkus, Daphne, Bergen, Ingrid M, de Raaf, Michiel A, Bogaard, Harm Jan, Boon, Louis, van Loo, Geert, Aerts, Joachim G J V, Boomars, Karin A, Kool, Mirjam, Hendriks, Rudi W

“…Chronic perivascular inflammation is a prominent feature in the lungs of idiopathic pulmonary arterial hypertension. Although the proportions of conventional…”
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Systemic CD4+ and CD8+ T-cell cytokine profiles correlate with GOLD stage in stable COPD by PAATS, Marthe S, BERGEN, Ingrid M, HOOGSTEDEN, Henk C, DER EERDEN, Menno M. Van, HENDRIKS, Rudi W

“…Chronic obstructive pulmonary disease (COPD) is associated with pulmonary and systemic inflammation. Both CD4+ and CD8+ T-lymphocytes play a key role in COPD…”
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DNGR1-mediated deletion of A20/Tnfaip3 in dendritic cells alters T and B-cell homeostasis and promotes autoimmune liver pathology by Das, Tridib, Bergen, Ingrid M., Koudstaal, Thomas, van Hulst, Jennifer A.C., van Loo, Geert, Boonstra, André, Vanwolleghem, Thomas, Leung, Patrick S.C., Gershwin, M. Eric, Hendriks, Rudi W., Kool, Mirjam

“…Dendritic cells (DCs) are central regulators of tolerance versus immunity. The outcome depends amongst others on DC subset and activation status. Whereas…”
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Evidence for a Role of CCR6+ T Cells in Chronic Thromboembolic Pulmonary Hypertension by van Uden, Denise, Koudstaal, Thomas, van Hulst, Jennifer A C, van den Bosch, Thierry P P, Vink, Madelief, Bergen, Ingrid M, Lila, Karishma A, van den Bosch, Annemien E, Bresser, Paul, Kool, Mirjam, von der Thüsen, Jan H, Hendriks, Rudi W, Boomars, Karin A

“…Previous studies have shown an increase of T cells and chemokines in vascular lesions of patients with chronic thromboembolic pulmonary hypertension (CTEPH)…”
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House dust mite‐driven neutrophilic airway inflammation in mice with TNFAIP3‐deficient myeloid cells is IL‐17‐independent by Vroman, Heleen, Das, Tridib, Bergen, Ingrid M., Hulst, Jennifer A. C., Ahmadi, Fatemeh, Loo, Geert, Lubberts, Erik, Hendriks, Rudi W., Kool, Mirjam

“…Summary Background Asthma is a heterogeneous disease of the airways that involves several types of granulocytic inflammation. Recently, we have shown that the…”
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Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation by Li, Bobby W S, Stadhouders, Ralph, de Bruijn, Marjolein J W, Lukkes, Melanie, Beerens, Dior M J M, Brem, Maarten D, KleinJan, Alex, Bergen, Ingrid, Vroman, Heleen, Kool, Mirjam, van IJcken, Wilfred F J, Rao, Tata Nageswara, Fehling, Hans Jörg, Hendriks, Rudi W

“…Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate source of the type 2 cytokines IL-5 and IL-13. However, their…”
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