Search Results - "Bergen, Dylan J M"

Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease by Bergen, Dylan J M, Tong, Qiao, Shukla, Ankit, Newham, Elis, Zethof, Jan, Lundberg, Mischa, Ryan, Rebecca, Youlten, Scott E, Frysz, Monika, Croucher, Peter I, Flik, Gert, Richardson, Rebecca J, Kemp, John P, Hammond, Chrissy L, Metz, Juriaan R

“…Scales are mineralised exoskeletal structures that are part of the dermal skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates…”
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Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression by Stevenson, Nicola L, Bergen, Dylan J M, Skinner, Roderick E H, Kague, Erika, Martin-Silverstone, Elizabeth, Robson Brown, Kate A, Hammond, Chrissy L, Stephens, David J

“…The Golgi is the cellular hub for complex glycosylation, controlling accurate processing of complex proteoglycans, receptors, ligands and glycolipids. Its…”
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Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds by Bergen, Dylan J M, Kague, Erika, Hammond, Chrissy L

“…Osteoporosis is metabolic bone disease caused by an altered balance between bone anabolism and catabolism. This dysregulated balance is responsible for fragile…”
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The Golgi matrix protein giantin is required for normal cilia function in zebrafish by Bergen, Dylan J M, Stevenson, Nicola L, Skinner, Roderick E H, Stephens, David J, Hammond, Christina L

“…The Golgi is essential for glycosylation of newly synthesised proteins including almost all cell-surface and extracellular matrix proteoglycans. Giantin,…”
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Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control by Stevenson, Nicola L, Bergen, Dylan J M, Xu, Amadeus, Wyatt, Emily, Henry, Freya, McCaughey, Janine, Vuolo, Laura, Hammond, Chrissy L, Stephens, David J

“…Almost every cell in the human body extends a primary cilium. Defective cilia function leads to a set of disorders known as ciliopathies, which are…”
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Giantin is required for intracellular N-terminal processing of type I procollagen by Stevenson, Nicola L, Bergen, Dylan J M, Lu, Yinhui, Prada-Sanchez, M Esther, Kadler, Karl E, Hammond, Chrissy L, Stephens, David J

“…Knockout of the golgin giantin leads to skeletal and craniofacial defects driven by poorly studied changes in glycosylation and extracellular matrix…”
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High Bone Mass Disorders: New Insights From Connecting the Clinic and the Bench by Bergen, Dylan J.M., Maurizi, Antonio, Formosa, Melissa M., McDonald, Georgina L.K., El‐Gazzar, Ahmed, Hassan, Neelam, Brandi, Maria‐Luisa, Riancho, José A., Rivadeneira, Fernando, Ntzani, Evangelia, Duncan, Emma L., Gregson, Celia L., Kiel, Douglas P., Zillikens, M. Carola, Sangiorgi, Luca, Högler, Wolfgang, Duran, Ivan, Mäkitie, Outi, Van Hul, Wim, Hendrickx, Gretl

“…ABSTRACT Monogenic high bone mass (HBM) disorders are characterized by an increased amount of bone in general, or at specific sites in the skeleton. Here, we…”
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A Roadmap to Gene Discoveries and Novel Therapies in Monogenic Low and High Bone Mass Disorders by Formosa, Melissa M, Bergen, Dylan J M, Gregson, Celia L, Maurizi, Antonio, Kämpe, Anders, Garcia-Giralt, Natalia, Zhou, Wei, Grinberg, Daniel, Ovejero Crespo, Diana, Zillikens, M Carola, Williams, Graham R, Bassett, J H Duncan, Brandi, Maria Luisa, Sangiorgi, Luca, Balcells, Susanna, Högler, Wolfgang, Van Hul, Wim, Mäkitie, Outi

“…Genetic disorders of the skeleton encompass a diverse group of bone diseases differing in clinical characteristics, severity, incidence and molecular etiology…”
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Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations by McDonald, Georgina L K, Wang, Mengdi, Hammond, Chrissy L, Bergen, Dylan J M

“…Osteoporosis and other conditions associated with low bone density or quality are highly prevalent, are increasing as the population ages and with increased…”
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Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence by Guiu, Jordi, Bergen, Dylan J M, De Pater, Emma, Islam, Abul B M M K, Ayllón, Verónica, Gama-Norton, Leonor, Ruiz-Herguido, Cristina, González, Jessica, López-Bigas, Nuria, Menendez, Pablo, Dzierzak, Elaine, Espinosa, Lluis, Bigas, Anna

“…Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements…”
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A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD‐Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis by Gregson, Celia L, Bergen, Dylan J. M., Leo, Paul, Sessions, Richard B, Wheeler, Lawrie, Hartley, April, Youlten, Scott, Croucher, Peter I, McInerney‐Leo, Aideen M, Fraser, William, Tang, Jonathan CY, Anderson, Lisa, Marshall, Mhairi, Sergot, Leon, Paternoster, Lavinia, Davey Smith, George, Brown, Matthew A, Hammond, Chrissy, Kemp, John P, Tobias, Jon H, Duncan, Emma L

“…ABSTRACT Novel anabolic drug targets are needed to treat osteoporosis. Having established a large national cohort with unexplained high bone mass (HBM), we…”
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Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure by Williamson, Rosalind C, Cowell, Christopher A M, Hammond, Christina L, Bergen, Dylan J M, Roper, James A, Feng, Yi, Rendall, Thomas C S, Race, Paul R, Bass, Mark D

“…Sustained forward migration through a fibrillar extracellular matrix requires localization of protrusive signals. Contact with fibronectin at the tip of a cell…”
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Melanocortin Receptor 4 Deficiency Affects Body Weight Regulation, Grooming Behavior, and Substrate Preference in the Rat by Mul, Joram D., Boxtel, Ruben, Bergen, Dylan J.M., Brans, Maike A.D., Brakkee, Jan H., Toonen, Pim W., Garner, Keith M., Adan, Roger A.H., Cuppen, Edwin

“…Obesity is caused by an imbalance between energy intake and expenditure and has become a major health‐care problem in western society. The central melanocortin…”
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Correction: Giantin is required for intracellular N-terminal processing of type I procollagen by Stevenson, Nicola L., Bergen, Dylan J.M., Lu, Yinhui, Prada-Sanchez, M. Esther, Kadler, Karl E., Hammond, Chrissy L., Stephens, David J.

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