Search Results - "Bergö, Martin"

Podocyte Geranylgeranyl Transferase Type-I Is Essential for Maintenance of the Glomerular Filtration Barrier by Boi, Roberto, Bergwall, Lovisa, Ebefors, Kerstin, Bergö, Martin O, Nyström, Jenny, Buvall, Lisa

“…A tightly regulated actin cytoskeleton attained through balanced activity of RhoGTPases is crucial to maintaining podocyte function. However, how RhoGTPases…”
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Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression by Court, Helen, Amoyel, Marc, Hackman, Michael, Lee, Kyoung Eun, Xu, Ruliang, Miller, George, Bar-Sagi, Dafna, Bach, Erika A, Bergö, Martin O, Philips, Mark R

“…RAS is the most frequently mutated oncogene in human cancers. Despite decades of effort, anti-RAS therapies have remained elusive. Isoprenylcysteine…”
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The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway by Gul, Nadia, Karlsson, Joakim, Tängemo, Carolina, Linsefors, Sanna, Tuyizere, Samuel, Perkins, Rosie, Ala, Chandu, Zou, Zhiyuan, Larsson, Erik, Bergö, Martin O., Lindahl, Per

“…The mut-T homolog-1 (MTH1) inhibitor TH588 has shown promise in preclinical cancer studies but its targeting specificity has been questioned. Alternative…”
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Response by Akyürek et al to Letter Regarding Article, “Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis” by Akyürek, Levent M, Bergo, Martin O, Bandaru, Sashidar

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Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice by Jeong, Angela, Cheng, Shaowu, Zhong, Rui, Bennett, David A, Bergö, Martin O, Li, Ling

“…The pathogenic mechanisms underlying the development of Alzheimer's disease (AD) remain elusive and to date there are no effective prevention or treatment for…”
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Rho-GTPase dependent leukocyte interaction generates pro-inflammatory thymic Tregs and causes arthritis by Malmhäll-Bah, Eric, Andersson, Karin M.E., Erlandsson, Malin C., Akula, Murali K., Brisslert, Mikael, Wiel, Clotilde, El Zowalaty, Ahmed E., Sayin, Volkan I., Bergö, Martin O., Bokarewa, Maria I.

“…Conditional mutation of protein geranylgeranyltransferase type I (GGTase-I) in macrophages (GLC) activates Rho-GTPases and causes arthritis in mice. Knocking…”
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Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress by Du, X., Zeng, H., Liu, S., Guy, C., Dhungana, Y., Neale, G., Bergö, Martin O., Chi, H.

“…Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Despite the roles of G protein–coupled receptors in thymocyte…”
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Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin alpha 4 beta 7 and Development of Colitis in Mice by Lopez-Posadas, R., Fastancz, P., Martinez-Sanchez, L. D., Panteleev-Ivlev, J., Thonn, V., Kisseleva, T., Becker, L. S., Schulz-Kuhnt, A., Zundler, S., Wirtz, S., Atreya, R., Carle, B., Friedrich, O., Schurmann, S., Waldner, M. J., Neufert, C., Brakebusch, C. H., Bergö, Martin, Neurath, M. F., Atreya, I.

“…BACKGROUND & AIMS: It is not clear how regulation of T-cell function is altered during development of inflammatory bowel diseases (IBD). We studied the…”
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Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway by Zou, Zhiyuan V., Gul, Nadia, Lindberg, Markus, Bokhari, Abdulmalik A., Eklund, Ella M., Garellick, Viktor, Patel, Angana A. H., Dzanan, Jozefina J., Titmuss, Ben O., Le Gal, Kristell, Johansson, Inger, Tivesten, Åsa, Forssell-Aronsson, Eva, Bergö, Martin O., Staffas, Anna, Larsson, Erik, Sayin, Volkan I., Lindahl, Per

“…Recent data suggest that the transcription factor Zfp148 represses activation of the tumor suppressor p53 in mice and that therapeutic targeting of the human…”
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Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice by López-Posadas, Rocío, Fastancz, Petra, Martínez-Sánchez, Luz del Carmen, Panteleev-Ivlev, Julia, Thonn, Veronika, Kisseleva, Tatyana, Becker, Lukas S., Schulz-Kuhnt, Anja, Zundler, Sebastian, Wirtz, Stefan, Atreya, Raja, Carlé, Birgitta, Friedrich, Oliver, Schürmann, Sebastian, Waldner, Maximilian J., Neufert, Clemens, Brakebusch, Cord H., Bergö, Martin O., Neurath, Markus F., Atreya, Imke

“…It is not clear how regulation of T-cell function is altered during development of inflammatory bowel diseases (IBD). We studied the mechanisms by which…”
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Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation by López-Posadas, Rocío, Becker, Christoph, Günther, Claudia, Tenzer, Stefan, Amann, Kerstin, Billmeier, Ulrike, Atreya, Raja, Fiorino, Gionata, Vetrano, Stefania, Danese, Silvio, Ekici, Arif B, Wirtz, Stefan, Thonn, Veronika, Watson, Alastair J M, Brakebusch, Cord, Bergö, Martin, Neurath, Markus F, Atreya, Imke

“…Although defects in intestinal barrier function are a key pathogenic factor in patients with inflammatory bowel diseases (IBDs), the molecular pathways driving…”
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Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes by Lee, Roger, Chang, Sandy Y., Trinh, Hung, Tu, Yiping, White, Andrew C., Davies, Brandon S.J., Bergo, Martin O., Fong, Loren G., Lowry, William E., Young, Stephen G.

“…The modification of proteins with farnesyl or geranylgeranyl lipids, a process called protein prenylation, facilitates interactions of proteins with membrane…”
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BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis by Wiel, Clotilde, Le Gal, Kristell, Ibrahim, Mohamed X., Jahangir, Chowdhury Arif, Kashif, Muhammad, Yao, Haidong, Ziegler, Dorian V., Xu, Xiufeng, Ghosh, Tanushree, Mondal, Tanmoy, Kanduri, Chandrasekhar, Lindahl, Per, Sayin, Volkan I., Bergo, Martin O.

“…For tumors to progress efficiently, cancer cells must overcome barriers of oxidative stress. Although dietary antioxidant supplementation or activation of…”
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Antioxidants accelerate lung cancer progression in mice by Sayin, Volkan I, Ibrahim, Mohamed X, Larsson, Erik, Nilsson, Jonas A, Lindahl, Per, Bergo, Martin O

“…Antioxidants are widely used to protect cells from damage induced by reactive oxygen species (ROS). The concept that antioxidants can help fight cancer is…”
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Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch by Luu, Thuy T, Schmied, Laurent, Nguyen, Ngoc-Anh, Wiel, Clotilde, Meinke, Stephan, Mohammad, Dara K, Bergö, Martin, Alici, Evren, Kadri, Nadir, Ganesan, Sridharan, Höglund, Petter

“…IL-15 priming of NK cells is a broadly accepted concept, but the dynamics and underlying molecular mechanisms remain poorly understood. We show that as little…”
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Antioxidants can increase melanoma metastasis in mice by Le Gal, Kristell, Ibrahim, Mohamed X, Wiel, Clotilde, Sayin, Volkan I, Akula, Murali K, Karlsson, Christin, Dalin, Martin G, Akyürek, Levent M, Lindahl, Per, Nilsson, Jonas, Bergo, Martin O

“…Antioxidants in the diet and supplements are widely used to protect against cancer, but clinical trials with antioxidants do not support this concept. Some…”
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Sa1756 Geranylgeranylation in Intestinal Epithelial Cells Impacts Cytoskeletal Arrangement and Is Pivotal for Gut Homeostasis by Lopez-Posadas, Rocio, Bergö, Martin O, Becker, Christoph, de Medina, Fermín Sánchez, Neurath, Markus F, Atreya, Imke

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Tu1853 Geranylgeranyltransferase Activity in Gut Epithelial Cells is Essential for Intestinal Homeostasis by Lopez-Posadas, Rocio, Bergö, Martin O, Becker, Christoph, Sánchez de Medina, Fermín, Neurath, Markus F, Atreya, Imke

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The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes by Griveau, Audrey, Wiel, Clotilde, Ziegler, Dorian V., Bergo, Martin O., Bernard, David

“…Hutchinson–Gilford progeria syndrome (HGPS) is caused by an LMNA mutation that results in the production of the abnormal progerin protein. Children with HGPS…”
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Lack of RAC1 in macrophages protects against atherosclerosis by Bandaru, Sashidar, Ala, Chandu, Ekstrand, Matias, Akula, Murali K, Pedrelli, Matteo, Liu, Xi, Bergström, Göran, Håversen, Liliana, Borén, Jan, Bergo, Martin O, Akyürek, Levent M, Lutgens, Esther, Bader, Michael

“…The Rho GTPase RAC1 is an important regulator of cytoskeletal dynamics, but the role of macrophage-specific RAC1 has not been explored during atherogenesis. We…”
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