Search Results - "Berens, Michael E"

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition by Hangauer, Matthew J., Viswanathan, Vasanthi S., Ryan, Matthew J., Bole, Dhruv, Eaton, John K., Matov, Alexandre, Galeas, Jacqueline, Dhruv, Harshil D., Berens, Michael E., Schreiber, Stuart L., McCormick, Frank, McManus, Michael T.

“…Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4. Reservoir of resistance…”
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Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data by Yang, Wei, Warrington, Nicole M, Taylor, Sara J, Whitmire, Paula, Carrasco, Eduardo, Singleton, Kyle W, Wu, Ningying, Lathia, Justin D, Berens, Michael E, Kim, Albert H, Barnholtz-Sloan, Jill S, Swanson, Kristin R, Luo, Jingqin, Rubin, Joshua B

“…Sex differences in the incidence and outcome of human disease are broadly recognized but, in most cases, not sufficiently understood to enable sex-specific…”
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Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy by Panditharatna, Eshini, Kilburn, Lindsay B, Aboian, Mariam S, Kambhampati, Madhuri, Gordish-Dressman, Heather, Magge, Suresh N, Gupta, Nalin, Myseros, John S, Hwang, Eugene I, Kline, Cassie, Crawford, John R, Warren, Katherine E, Cha, Soonmee, Liang, Winnie S, Berens, Michael E, Packer, Roger J, Resnick, Adam C, Prados, Michael, Mueller, Sabine, Nazarian, Javad

“…Pediatric diffuse midline glioma (DMG) are highly malignant tumors with poor clinical outcomes. Over 70% of patients with DMG harbor the histone 3 p.K27M…”
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Evaluation of pre-analytical factors affecting plasma DNA analysis by Markus, Havell, Contente-Cuomo, Tania, Farooq, Maria, Liang, Winnie S., Borad, Mitesh J., Sivakumar, Shivan, Gollins, Simon, Tran, Nhan L., Dhruv, Harshil D., Berens, Michael E., Bryce, Alan, Sekulic, Aleksandar, Ribas, Antoni, Trent, Jeffrey M., LoRusso, Patricia M., Murtaza, Muhammed

“…Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample…”
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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma by Fons, Nathan R., Sundaram, Ranjini K., Breuer, Gregory A., Peng, Sen, McLean, Ryan L., Kalathil, Aravind N., Schmidt, Mark S., Carvalho, Diana M., Mackay, Alan, Jones, Chris, Carcaboso, Ángel M., Nazarian, Javad, Berens, Michael E., Brenner, Charles, Bindra, Ranjit S.

“…Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in their gliomagenesis and the lack…”
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Molecular mechanisms of glioma cell migration and invasion by Demuth, Tim, Berens, Michael E

“…Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients die with glioblastoma per year (CBTRUS 2002). Despite modern…”
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Integrated genomic and epigenomic analysis of breast cancer brain metastasis by Salhia, Bodour, Kiefer, Jeff, Ross, Julianna T D, Metapally, Raghu, Martinez, Rae Anne, Johnson, Kyle N, DiPerna, Danielle M, Paquette, Kimberly M, Jung, Sungwon, Nasser, Sara, Wallstrom, Garrick, Tembe, Waibhav, Baker, Angela, Carpten, John, Resau, Jim, Ryken, Timothy, Sibenaller, Zita, Petricoin, Emanuel F, Liotta, Lance A, Ramanathan, Ramesh K, Berens, Michael E, Tran, Nhan L

“…The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes. The purpose of our…”
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Toward precision medicine in glioblastoma: the promise and the challenges by Prados, Michael D, Byron, Sara A, Tran, Nhan L, Phillips, Joanna J, Molinaro, Annette M, Ligon, Keith L, Wen, Patrick Y, Kuhn, John G, Mellinghoff, Ingo K, de Groot, John F, Colman, Howard, Cloughesy, Timothy F, Chang, Susan M, Ryken, Timothy C, Tembe, Waibhav D, Kiefer, Jeffrey A, Berens, Michael E, Craig, David W, Carpten, John D, Trent, Jeffrey M

“…Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have…”
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Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway by Singh, Shiv K., Fiorelli, Roberto, Kupp, Robert, Rajan, Sindhu, Szeto, Emily, Lo Cascio, Costanza, Maire, Cecile L., Sun, Yu, Alberta, John A., Eschbacher, Jennifer M., Ligon, Keith L., Berens, Michael E., Sanai, Nader, Mehta, Shwetal

“…In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the…”
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Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas by Berens, Michael E, Sood, Anup, Barnholtz-Sloan, Jill S, Graf, John F, Cho, Sanghee, Kim, Seungchan, Kiefer, Jeffrey, Byron, Sara A, Halperin, Rebecca F, Nasser, Sara, Adkins, Jonathan, Cuyugan, Lori, Devine, Karen, Ostrom, Quinn, Couce, Marta, Wolansky, Leo, McDonough, Elizabeth, Schyberg, Shannon, Dinn, Sean, Sloan, Andrew E, Prados, Michael, Phillips, Joanna J, Nelson, Sarah J, Liang, Winnie S, Al-Kofahi, Yousef, Rusu, Mirabela, Zavodszky, Maria I, Ginty, Fiona

“…Glioma is recognized to be a highly heterogeneous CNS malignancy, whose diverse cellular composition and cellular interactions have not been well…”
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Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells by Dhruv, Harshil D, McDonough Winslow, Wendy S, Armstrong, Brock, Tuncali, Serdar, Eschbacher, Jenny, Kislin, Kerri, Loftus, Joseph C, Tran, Nhan L, Berens, Michael E

“…Histology of malignant glioma depicts dense proliferative areas rich in angiogenesis as well as dissemination of neoplastic cells into adjacent brain tissue…”
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miRNA expression profiling in migrating glioblastoma cells: regulation of cell migration and invasion by miR-23b via targeting of Pyk2 by Loftus, Joseph C, Ross, Julianna T D, Paquette, Kimberly M, Paulino, Vincent M, Nasser, Sara, Yang, Zhongbo, Kloss, Jean, Kim, Seungchan, Berens, Michael E, Tran, Nhan L

“…Glioblastoma (GB) is the most common and lethal type of primary brain tumor. Clinical outcome remains poor and is essentially palliative due to the highly…”
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Therapeutic HDAC inhibition in hypermutant diffuse intrinsic pontine glioma by Noll, Alyssa, Myers, Carrie, Biery, Matthew C, Meechan, Michael, Tahiri, Sophie, Rajendran, Asmitha, Berens, Michael E, Paine, Danyelle, Byron, Sara, Zhang, Jiaming, Winter, Conrad, Pakiam, Fiona, Leary, Sarah E S, Cole, Bonnie L, Jackson, Evangeline R, Dun, Matthew D, Foster, Jessica B, Evans, Myron K, Pattwell, Siobhan S, Olson, James M, Vitanza, Nicholas A

“…Constitutional mismatch repair deficiency (CMMRD) is a cancer predisposition syndrome associated with the development of hypermutant pediatric high-grade…”
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Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule‐dependency by Mikkelsen, Tom, Brodie, Chaya, Finniss, Susan, Berens, Michael E., Rennert, Jessica L., Nelson, Kevin, Lemke, Nancy, Brown, Stephen L., Hahn, Diane, Neuteboom, Berend, Goodman, Simon L.

“…We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific…”
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The Guanine Nucleotide Exchange Factors Trio, Ect2, and Vav3 Mediate the Invasive Behavior of Glioblastoma by Salhia, Bodour, Tran, Nhan L, Chan, Amanda, Wolf, Amparo, Nakada, Mitsutoshi, Rutka, Fiona, Ennis, Matthew, McDonough, Wendy S, Berens, Michael E, Symons, Marc, Rutka, James T

“…Malignant gliomas are characterized by their ability to invade normal brain tissue. We have previously shown that the small GTPase Rac1 plays a role in both…”
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The small GTPase RhoG mediates glioblastoma cell invasion by Kwiatkowska, Aneta, Didier, Sebastien, Fortin, Shannon, Chuang, Yayu, White, Timothy, Berens, Michael E, Rushing, Elisabeth, Eschbacher, Jennifer, Tran, Nhan L, Chan, Amanda, Symons, Marc

“…The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas. Previous…”
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The phosphorylation of ephrin‐B2 ligand promotes glioma cell migration and invasion by Nakada, Mitsutoshi, Anderson, Eric M., Demuth, Tim, Nakada, Satoko, Reavie, Linsey B., Drake, Kelsey L., Hoelzinger, Dominique B., Berens, Michael E.

“…To reveal molecular drivers of glioma invasion, two distinct glioblastoma (GBM) cell phenotypes (invading cells and tumor core cells) were collected from 19…”
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Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression by Fortin Ensign, Shannon Patricia, Mathews, Ian T, Symons, Marc H, Berens, Michael E, Tran, Nhan L

“…Glioblastoma (GB) is the most malignant of primary adult brain tumors, characterized by a highly locally invasive cell population, as well as abundant…”
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Ephrin-B3 ligand promotes glioma invasion through activation of rac1 by NAKADA, Mitsutoshi, DRAKE, Kelsey L, NAKADA, Satoko, NISKA, Jared A, BERENS, Michael E

“…Eph receptor tyrosine kinases are involved in nervous system development. Eph ligands, termed ephrins, are transmembrane proteins that bind to Eph receptors,…”
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Novel Brain-Penetrant, Small-Molecule Tubulin Destabilizers for the Treatment of Glioblastoma by Patrón, Lilian A, Yeoman, Helen, Wilson, Sydney, Tang, Nanyun, Berens, Michael E, Gokhale, Vijay, Suzuki, Teri C

“…Glioblastoma (GB) is the most lethal brain cancer in adults, with a 5-year survival rate of 5%. The standard of care for GB includes maximally safe surgical…”
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