Search Results - "Berdov, Boris A"

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer by Hingorani, Sunil R, Harris, William P, Beck, J Thaddeus, Berdov, Boris A, Wagner, Stephanie A, Pshevlotsky, Eduard M, Tjulandin, Sergei A, Gladkov, Oleg A, Holcombe, Randall F, Korn, Ronald, Raghunand, Natarajan, Dychter, Samuel, Jiang, Ping, Shepard, H Michael, Devoe, Craig E

“…This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and…”
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Exploratory biomarker results from early investigation of PEGPH20 in combination with gemcitabine (Gem) in patients with pancreatic cancer (PDA) by Hingorani, Sunil R., Harris, William Proctor, Beck, Joseph Thaddeus, Berdov, Boris A., Wagner, Stephanie Ann, Pshevlotsky, Eduard M., Tjulandin, Sergei, Gladkov, Oleg, Holcombe, Randall F., Jiang, Ping, Maneval, Daniel C., Korn, Ronald I, Shepard, Harold Michael, Devoe, Craig E.

“…Abstract only 300 Background: PEGPH20 (PEG), a PEGylated recombinant human hyaluronidase, has anti-tumor activity as a single agent and in combination with…”
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Final results of a phase Ib study of gemcitabine plus PEGPH20 in patients with stage IV previously untreated pancreatic cancer by Hingorani, Sunil R., Harris, William Proctor, Beck, Joseph Thaddeus, Berdov, Boris A., Wagner, Stephanie Ann, Pshevlotsky, Eduard M., Tjulandin, Sergei, Gladkov, Oleg, Holcombe, Randall F., Jiang, Ping, Devoe, Craig E.

“…Abstract only 359 Background: Poor outcome in pancreatic cancer (PDA) has been associated with tumor stroma limiting access of chemotherapy drugs. PEGPH20…”
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A phase Ib study of gemcitabine plus PEGPH20 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer by Hingorani, Sunil R., Harris, William Proctor, Beck, J. Thaddeus, Berdov, Boris A., Wagner, Stephanie Ann, Pshevlotsky, Eduard M., Tjulandin, Sergei, Gladkov, Oleg, Holcombe, Randall F., Jiang, Ping, Maneval, Daniel C., Zhu, Joy, Devoe, Craig E.

“…Abstract only 4010 Background: PEGPH20 is a PEGylated version of human recombinant hyaluronidase. In preclinical studies, PEGPH20 depleted pancreatic cancers…”
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Pharmacokinetic (PK)/pharmacodynamic (PD) results from a phase Ib study of pegylated hyaluronidase PH20 (PEGPH20) in combination with gemcitabine (Gem) in patients with pancreatic cancer by Harris, William Proctor, Hingorani, Sunil R., Beck, Joseph Thaddeus, Berdov, Boris A., Wagner, Stephanie Ann, Pshevlotsky, Eduard M., Tjulandin, Sergei, Gladkov, Oleg, Holcombe, Randall F., Jiang, Ping, Maneval, Daniel C., Zhu, Joy, Devoe, Craig E.

“…Abstract only e15005 Background: Enzymatic degradation of hyaluronan (HA) is a novel strategy to target the desmoplastic stroma of pancreatic cancer. PEGPH20,…”
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