No association between anti-thyroidperoxidase antibodies and bipolar disorder: a study in the Dutch Bipolar Cohort and a meta-analysis

No association between anti-thyroidperoxidase antibodies and bipolar disorder: a study in the Dutch Bipolar Cohort and a meta-analysis

•TPO-abs is measured in plasma of bipolar patients, first-degree relatives and controls.•No significant differences in TPO-abs seroprevalence or antibody titers between these groups.•TPO-abs prevalence was not related to specific clinical factors, including lithium us.•A meta-analysis reaffirmed the...

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Bibliographic Details
Published in:Psychoneuroendocrinology Vol. 112; p. 104518
Main Authors: Snijders, G.J.L.J., de Witte, L.D., van den Berk, D., van der Laan, C., Regeer, E., Begemann, M.J.H., Berdenis van Berlekom, A., Litjens, M., Boks, M.P., Ophoff, R.A., Kahn, R.S., Hillegers, M.H.J.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-02-2020
Subjects:
Adult
Aged
Antithyroid microsomal antibody
Autoantibodies - blood
Autoantigens - immunology
Autoimmune Diseases - blood
Autoimmune Diseases - epidemiology
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - epidemiology
Comorbidity
Family
Female
Humans
Iodide Peroxidase - immunology
Iron-Binding Proteins - immunology
Male
Middle Aged
Netherlands - epidemiology
Risk
Seroepidemiologic Studies
Thyroid diseases
Netherlands
Bipolar disorder
Antithyroid microsomal antibody
Thyroid diseases
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Summary:•TPO-abs is measured in plasma of bipolar patients, first-degree relatives and controls.•No significant differences in TPO-abs seroprevalence or antibody titers between these groups.•TPO-abs prevalence was not related to specific clinical factors, including lithium us.•A meta-analysis reaffirmed the absence of an association of BD with TPO-abs. Thyroid autoimmunity has been associated with bipolar disorder (BD). However, results from previous studies on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent. The aim of the present study is to investigate whether the seroprevalence and titer levels of TPO-abs are related to BD. TPO-abs were measured in plasma samples of 760 patients with bipolar disorder, 261 first-degree relatives and 363 controls by enzyme-linked immunosorbent assay (ELISA). To address methodological limitations of previous studies, we assessed clinical characteristics with several (self-reported) questionnaires to investigate whether TPO-abs positivity is related to particular clinical subgroups of BD patients. We performed an additional meta-analysis of seroprevalences of TPO-abs in BD patients including data from present and previous studies. Seroprevalence or titer levels of TPO-abs did not significantly differ between patients with BD, their first-degree relatives, and controls. In BD patients, the prevalence of TPO-abs was unrelated to specific clinical factors, including lithium use. Our meta-analysis of twelve studies showed an overall odds ratio of 1.3 (CI 95 %: 0.7–2.3; p = 0.30), reaffirming the absence of an association of BD with TPO-abs. In the largest study of TPO-abs in BD to date, our findings indicate that TPO-abs are not associated with (the risk for) bipolar disorder.
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ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2019.104518