Search Results - "Beraldi, Eliana"

Moving Towards Precision Urologic Oncology: Targeting Enzalutamide-resistant Prostate Cancer and Mutated Forms of the Androgen Receptor Using the Novel Inhibitor Darolutamide (ODM-201) by Borgmann, Hendrik, Lallous, Nada, Ozistanbullu, Deniz, Beraldi, Eliana, Paul, Naman, Dalal, Kush, Fazli, Ladan, Haferkamp, Axel, Lejeune, Pascale, Cherkasov, Artem, Gleave, Martin E.

“…Darolutamide (ODM-201) is a novel androgen receptor (AR) antagonist with a chemical structure distinctly different from currently approved AR antagonists that…”
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Hsp27 Regulates Epithelial Mesenchymal Transition, Metastasis, and Circulating Tumor Cells in Prostate Cancer by SHIOTA, Masaki, BISHOP, Jennifer L, GLEAVE, Martin, ZOUBEIDI, Amina, MUN NIP, Ka, ZARDAN, Anousheh, TAKEUCHI, Ario, CORDONNIER, Thomas, BERALDI, Eliana, BAZOV, Jenny, FAZLI, Ladan, CHI, Kim

“…Defining the mechanisms underlying metastatic progression of prostate cancer may lead to insights into how to decrease morbidity and mortality in this disease…”
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Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models by Nappi, Lucia, Aguda, Adeleke H, Nakouzi, Nader Al, Lelj-Garolla, Barbara, Beraldi, Eliana, Lallous, Nada, Thi, Marisa, Moore, Susan, Fazli, Ladan, Battsogt, Dulguun, Stief, Sophie, Ban, Fuqiang, Nguyen, Nham T, Saxena, Neetu, Dueva, Evgenia, Zhang, Fan, Yamazaki, Takeshi, Zoubeidi, Amina, Cherkasov, Artem, Brayer, Gary D, Gleave, Martin

“…HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a…”
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Generation 2.5 antisense oligonucleotides targeting the androgen receptor and its splice variants suppress enzalutamide-resistant prostate cancer cell growth by Yamamoto, Yoshiaki, Loriot, Yohann, Beraldi, Eliana, Zhang, Fan, Wyatt, Alexander W, Al Nakouzi, Nader, Mo, Fan, Zhou, Tianyuan, Kim, Youngsoo, Monia, Brett P, MacLeod, A Robert, Fazli, Ladan, Wang, Yuzhuo, Collins, Colin C, Zoubeidi, Amina, Gleave, Martin

“…Enzalutamide (ENZ) is a potent androgen receptor (AR) antagonist with activity in castration-resistant prostate cancer (CRPC); however, progression to…”
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Design and Characterization of Injectable Poly(Lactic-Co-Glycolic Acid) Pastes for Sustained and Local Drug Release by Schmitt, Veronika, Kesch, Claudia, Jackson, John K., Bidnur, Samir, Beraldi, Eliana, Yago, Virginia, Bowden, Mary, Gleave, Martin E.

“…Purpose We describe the preparation of injectable polymeric paste (IPP) formulations for local and sustained release of drugs. Furthermore, we include the…”
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Cooperative Interactions between Androgen Receptor (AR) and Heat-Shock Protein 27 Facilitate AR Transcriptional Activity by ZOUBEIDI, Amina, ZARDAN, Anousheh, BERALDI, Eliana, FAZLI, Ladan, SOWERY, Richard, RENNIE, Paul, NELSON, Colleen, GLEAVE, Martin

“…Androgen receptor (AR) transactivation is known to enhance prostate cancer cell survival. However, the precise effectors by which the prosurvival effects of…”
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Cotargeting Androgen Receptor and Clusterin Delays Castrate-Resistant Prostate Cancer Progression by Inhibiting Adaptive Stress Response and AR Stability by MATSUMOTO, Hiroaki, YAMAMOTO, Yoshiaki, SHIOTA, Masaki, KURUMA, Hidetoshi, BERALDI, Eliana, MATSUYAMA, Hideyasu, ZOUBEIDI, Amina, GLEAVE, Martin

“…Although androgen receptor (AR) pathway inhibitors prolong survival in castrate-resistant prostate cancer (CRPC), resistance rapidly develops and is often…”
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Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells by Kamada, Masayuki, So, Alan, Muramaki, Mototsugu, Rocchi, Palma, Beraldi, Eliana, Gleave, Martin

“…Heat shock protein 27 (Hsp27) is a cytoprotective chaperone that is phosphoactivated during cell stress that prevents aggregation and/or regulate activity and…”
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Hsp27 Promotes Insulin-Like Growth Factor-I Survival Signaling in Prostate Cancer via p90Rsk-Dependent Phosphorylation and Inactivation of BAD by ZOUBEIDI, Amina, ZARDAN, Anousheh, WIEDMANN, Romina M, LOCKE, Jennifer, BERALDI, Eliana, FAZLI, Ladan, GLEAVE, Martin E

“…Hsp27 is highly expressed in castrate-resistant prostate cancer. Although its overexpression confers resistance to androgen ablation and chemotherapy, the…”
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Clusterin Inhibition Using OGX-011 Synergistically Enhances Hsp90 Inhibitor Activity by Suppressing the Heat Shock Response in Castrate-Resistant Prostate Cancer by LAMOUREUX, Francois, THOMAS, Christian, YIN, Min-Jean, KURUMA, Hidetoshi, BERALDI, Eliana, FAZLI, Ladan, ZOUBEIDI, Amina, GLEAVE, Martin E

“…Small-molecule inhibitors of Hsp90 show promise in the treatment of castrate-resistant prostate cancer (CRPC); however, these inhibitors trigger a heat shock…”
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Androgen receptor (AR) antagonism triggers acute succinate‐mediated adaptive responses to reactivate AR signaling by Saxena, Neetu, Beraldi, Eliana, Fazli, Ladan, Somasekharan, Syam Prakash, Adomat, Hans, Zhang, Fan, Molokwu, Chidi, Gleave, Anna, Nappi, Lucia, Nguyen, Kimberly, Brar, Pavn, Nikesitch, Nicholas, Wang, Yuzhuo, Collins, Colin, Sorensen, Poul H, Gleave, Martin

“…Treatment‐induced adaptive pathways converge to support androgen receptor (AR) reactivation and emergence of castration‐resistant prostate cancer (PCa) after…”
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Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer by ROCCHI, Palma, SO, Alan, KOJIMA, Satoko, SIGNAEVSKY, Maxim, BERALDI, Eliana, FAZLI, Ladan, HURTADO-COLL, Antonio, YAMANAKA, Kazuki, GLEAVE, Martin

“…Heat shock protein 27 (Hsp27) is a chaperone implicated as an independent predictor of clinical outcome in prostate cancer. Our aim was to characterize changes…”
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Increased Hsp27 after androgen ablation facilitates androgen- independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis by ROCCHI, Palma, BERALDI, Eliana, ETTINGER, Susan, FAZLI, Ladan, VESSELLA, Robert L, NELSON, Colleen, GLEAVE, Martin

“…One strategy to improve therapies in prostate cancer involves targeting cytoprotective genes activated by androgen withdrawal to delay the emergence of the…”
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A polymeric paste-drug formulation for local treatment of upper tract urothelial carcinoma by Kesch, Claudia, Schmitt, Veronika, Bidnur, Samir, Thi, Marisa, Beraldi, Eliana, Moskalev, Igor, Yago, Virginia, Bowden, Mary, Adomat, Hans, Fazli, Ladan, Jackson, John K., Gleave, Martin E.

“…•We developed a novel mucoadhesive, polymeric paste formulation of gemcitabine (ST-UC), that can be locally administered via direct instillation to the upper…”
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Cotargeting stress-activated Hsp27 and autophagy as a combinatorial strategy to amplify endoplasmic reticular stress in prostate cancer by Kumano, Masafumi, Furukawa, Junya, Shiota, Masaki, Zardan, Anousheh, Zhang, Fan, Beraldi, Eliana, Wiedmann, Romina M, Fazli, Ladan, Zoubeidi, Amina, Gleave, Martin E

“…Hsp27 is a stress-activated multifunctional chaperone that inhibits treatment-induced apoptosis and causes treatment resistance in prostate and other cancers…”
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Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis by Al Nakouzi, Nader, Wang, Chris Kedong, Beraldi, Eliana, Jager, Wolfgang, Ettinger, Susan, Fazli, Ladan, Nappi, Lucia, Bishop, Jennifer, Zhang, Fan, Chauchereau, Anne, Loriot, Yohann, Gleave, Martin

“…Clusterin (CLU) is a stress‐activated molecular chaperone that confers treatment resistance to taxanes when highly expressed. While CLU inhibition potentiates…”
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A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor by Xia, Yi, Wang, Menghua, Beraldi, Eliana, Cong, Mei, Zoubeidi, Amina, Gleave, Martin, Peng, Ling

“…A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1…”
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A polymeric paste-drug formulation for intratumoral treatment of prostate cancer by Kesch, Claudia, Schmitt, Veronika, Bidnur, Samir, Thi, Marisa, Beraldi, Eliana, Moskalev, Igor, Yago, Virginia, Bowden, Mary, Adomat, Hans, Fazil, Ladan, Jackson, John K., Gleave, Martin E.

“…Objective Focal therapy has emerged as a treatment option for low- to intermediate-risk localized prostate cancer (PCa) patients, to balance the risks for…”
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Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancer by Shiota, Masaki, Zoubeidi, Amina, Kumano, Masafumi, Beraldi, Eliana, Naito, Seiji, Nelson, Colleen C, Sorensen, Poul H B, Gleave, Martin E

“…Clusterin is a stress-activated, cytoprotective chaperone that confers broad-spectrum treatment resistance in cancer. However, the molecular mechanisms…”
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Transcription factor Stat5 knockdown enhances androgen receptor degradation and delays castration-resistant prostate cancer progression in vivo by Thomas, Christian, Zoubeidi, Amina, Kuruma, Hidetoshi, Fazli, Ladan, Lamoureux, Francois, Beraldi, Eliana, Monia, Brett P, MacLeod, A Robert, Thüroff, Joachim W, Gleave, Martin E

“…Signal transducer and activator of transcription 5 (Stat5) plays an important role in the transition of prostate cancer (PCa) to its castrate-resistant state…”
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