Search Results - "Berair, Rachid"

In vitro , in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss by Chernyavsky, Igor L, Russell, Richard J, Saunders, Ruth M, Morris, Gavin E, Berair, Rachid, Singapuri, Amisha, Chachi, Latifa, Mansur, Adel H, Howarth, Peter H, Dennison, Patrick, Chaudhuri, Rekha, Bicknell, Stephen, Rose, Felicity R A J, Siddiqui, Salman, Brook, Bindi S, Brightling, Christopher E

“…Bronchial thermoplasty is a treatment for asthma. It is currently unclear whether its histopathological impact is sufficiently explained by the proportion of…”
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Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial by Gonem, Sherif, PhD, Berair, Rachid, MBChB, Singapuri, Amisha, BSc, Hartley, Ruth, MBChB, Laurencin, Marie F M, BSc, Bacher, Gerald, PhD, Holzhauer, Björn, Dipl Math, Bourne, Michelle, BSc, Mistry, Vijay, BSc, Pavord, Ian D, Prof, Mansur, Adel H, PhD, Wardlaw, Andrew J, Prof, Siddiqui, Salman H, Prof, Kay, Richard A, PhD, Brightling, Christopher E, Prof

“…Summary Background Eosinophilic airway inflammation is often present in asthma, and reduction of such inflammation results in improved clinical outcomes. We…”
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Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling by Berair, Rachid, Hartley, Ruth, Mistry, Vijay, Sheshadri, Ajay, Gupta, Sumit, Singapuri, Amisha, Gonem, Sherif, Marshall, Richard P, Sousa, Ana R, Shikotra, Aarti, Kay, Richard, Wardlaw, Andrew, Bradding, Peter, Siddiqui, Salman, Castro, Mario, Brightling, Christopher E

“…Airway remodelling in asthma remains poorly understood. This study aimed to determine the association of airway remodelling measured on bronchial biopsies with…”
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In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K.A., Berair, Rachid, Lok, Laurence S.C., Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P., Summers, Charlotte, Wong, Anna, Solanki, Chandra K., Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A. Michael, Brightling, Christopher E., Condliffe, Alison M., Chilvers, Edwin R.

“…[...]there is a need to develop noninvasive biomarkers of tissue eosinophilia. [...]although we have previously published a rigorous assessment of the…”
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Airway Smooth Muscle Hypercontractility in Asthma by Berair, Rachid, Brightling, Christopher E., Hollins, Fay

“…In recent years, asthma has been defined primarily as an inflammatory disorder with emphasis on inflammation being the principle underlying pathophysiological…”
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Asthma Therapy and Its Effect on Airway Remodelling by Berair, Rachid, Brightling, Christopher E.

“…Asthma remains a major health problem with significant morbidity, mortality and economic costs. In asthma, airway remodelling, which refers to all the…”
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Fevipiprant, a prostaglandin D 2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial by Gonem, Sherif, Berair, Rachid, Singapuri, Amisha, Hartley, Ruth, Laurencin, Marie F M, Bacher, Gerald, Holzhauer, Björn, Bourne, Michelle, Mistry, Vijay, Pavord, Ian D, Mansur, Adel H, Wardlaw, Andrew J, Siddiqui, Salman H, Kay, Richard A, Brightling, Christopher E

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Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD by Hollins, Fay, Sutcliffe, Amanda, Gomez, Edith, Berair, Rachid, Russell, Richard, Szyndralewiez, Cédric, Saunders, Ruth, Brightling, Christopher

“…The burden of oxidative stress is increased in chronic obstructive pulmonary disease (COPD). However, whether the intra-cellular mechanisms controlling the…”
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Origins of increased airway smooth muscle mass in asthma by Berair, Rachid, Saunders, Ruth, Brightling, Christopher E

“…Asthma is characterized by both chronic inflammation and airway remodeling. Remodeling--the structural changes seen in asthmatic airways--is pivotal in the…”
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DP 2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment by Saunders, Ruth, Kaul, Himanshu, Berair, Rachid, Gonem, Sherif, Singapuri, Amisha, Sutcliffe, Amanda J, Chachi, Latifa, Biddle, Michael S, Kaur, Davinder, Bourne, Michelle, Pavord, Ian D, Wardlaw, Andrew J, Siddiqui, Salman H, Kay, Richard A, Brook, Bindi S, Smallwood, Rod H, Brightling, Christopher E

“…Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to…”
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Airway structural remodelling in asthma: functional relevance and suitability as a target for therapy by Berair, Rachid

“…Airway remodelling (AR) in asthma, a collective term describing all the airway microscopic structural changes, has long been known; however, its functional…”
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Severe asthma: novel advances in the pathogenesis and therapy by Hartley, Ruth, Berair, Rachid, Brightling, Christopher E

“…Asthma affects an estimated 300 million people worldwide and is severe in approximately 10% of sufferers. Asthma, especially severe asthma, is a heterogeneous…”
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Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma by Singh, Shailendra R, Sullo, Nikol, Matteis, Maria, Spaziano, Giuseppe, McDonald, John, Saunders, Ruth, Woodman, Lucy, Urbanek, Konrad, De Angelis, Antonella, De Palma, Raffaele, Berair, Rachid, Pancholi, Mitesh, Mistry, Vijay, Rossi, Francesco, Guerrini, Remo, Calò, Girolamo, D'Agostino, Bruno, Brightling, Christopher E, Lambert, David G

“…Background and Purpose There is evidence supporting a role for the nociceptin/orphanin FQ (N/OFQ; NOP) receptor and its endogenous ligand N/OFQ in the…”
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Reply by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K.A., Berair, Rachid, Lok, Laurence S.C., Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P., Summers, Charlotte, Wong, Anna, Solanki, Chandra K., Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A. Michael, Brightling, Christopher E., Condliffe, Alison M., Chilvers, Edwin R.

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Reply by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Adam KA Wright, Berair, Rachid, Lok, Laurence SC, Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P, Summers, Charlotte, Wong, Anna, Solanki, Chandra K, Buscombe, John, Pee Hwee Pang, Thavakumar, Arthikkaa, Peters, A Michael, Brightling, Christopher E, Condliffe, Alison M, Chilvers, Edwin R

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Rationale and Clinical Results of Inhibiting Interleukin-5 for the Treatment of Severe Asthma by Berair, Rachid, Pavord, Ian D.

“…Severe asthma is responsible for considerable morbidity and a high proportion of the healthcare costs attributable to asthma. Management is not straightforward…”
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Fibrocyte localisation to the ASM bundle in asthma: bidirectional effects on cell phenotype and behaviour by Saunders, Ruth, Kaur, Davinder, Desai, Dhananjay, Berair, Rachid, Chachi, Latifa, Thompson, Richard D, Siddiqui, Salman H, Brightling, Christopher E

“…Objectives Airway hyper‐responsiveness and persistent airflow obstruction contribute to asthma pathogenesis and symptoms, due in part to airway smooth muscle…”
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Reply by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K A, Berair, Rachid, Lok, Laurence S C, Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P, Summers, Charlotte, Wong, Anna, Solanki, Chandra K, Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A Michael, Brightling, Christopher E, Condliffe, Alison M, Chilvers, Edwin R

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Reply by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K A, Berair, Rachid, Lok, Laurence S C, Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P, Summers, Charlotte, Wong, Anna, Solanki, Chandra K, Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A Michael, Brightling, Christopher E, Condliffe, Alison M, Chilvers, Edwin R

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