Search Results - "Berahovich, Robert D"

Elucidation of CXCR7-Mediated Signaling Events and Inhibition of CXCR4-Mediated Tumor Cell Transendothelial Migration by CXCR7 Ligands by Zabel, Brian A, Wang, Yu, Lewen, Susanna, Berahovich, Robert D, Penfold, Mark E. T, Zhang, Penglie, Powers, Jay, Summers, Bretton C, Miao, Zhenhua, Zhao, Bin, Jalili, Ali, Janowska-Wieczorek, Anna, Jaen, Juan C, Schall, Thomas J

“…CXCR7 binds chemokines CXCL11 (I-TAC) and CXCL12 (SDF-1) but does not act as a classical chemoattractant receptor. Using CCX771, a novel small molecule with…”
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The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells by Zabel, Brian A, Lewén, Susanna, Berahovich, Robert D, Jaén, Juan C, Schall, Thomas J

“…Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4…”
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CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice by Sullivan, Timothy, Miao, Zhenhua, Dairaghi, Daniel J, Krasinski, Antoni, Wang, Yu, Zhao, Bin N, Baumgart, Trageen, Ertl, Linda S, Pennell, Andrew, Seitz, Lisa, Powers, Jay, Zhao, Ruiping, Ungashe, Solomon, Wei, Zheng, Boring, Landin, Tsou, Chia-Lin, Charo, Israel, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

“…Chemokine (C-C motif) receptor 2 (CCR2) is central for the migration of monocytes into inflamed tissues. The novel CCR2 antagonist CCX140-B, which is currently…”
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Evidence for NK Cell Subsets Based on Chemokine Receptor Expression by Berahovich, Robert D, Lai, Nu L, Wei, Zheng, Lanier, Lewis L, Schall, Thomas J

“…To help understand the role of chemokines in NK cell trafficking, we determined the chemokine receptor profiles of three different human NK cell lines and…”
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Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes by Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

“…Abstract Objective CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects. These results support the thesis that insulin…”
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Proteolytic Activation of Alternative CCR1 Ligands in Inflammation by Berahovich, Robert D, Miao, Zhenhua, Wang, Yu, Premack, Brett, Howard, Maureen C, Schall, Thomas J

“…Although chemokines CCL3/MIP-1alpha and CCL5/RANTES are considered to be primary CCR1 ligands in inflammatory responses, alternative CCR1 ligands have also…”
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CCR9 Antagonists in the Treatment of Ulcerative Colitis by Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.

“…While it has long been established that the chemokine receptor CCR9 and its ligand CCL25 are essential for the movement of leukocytes into the small intestine…”
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Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels by Berahovich, Robert D., Zabel, Brian A., Lewén, Susanna, Walters, Matthew J., Ebsworth, Karen, Wang, Yu, Jaen, Juan C., Schall, Thomas J.

“…Summary The concentration of CXCL12/SDF‐1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from…”
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CXCR7 protein is not expressed on human or mouse leukocytes by Berahovich, Robert D, Zabel, Brian A, Penfold, Mark E T, Lewén, Susanna, Wang, Yu, Miao, Zhenhua, Gan, Lin, Pereda, Jaime, Dias, Jessica, Slukvin, Igor I, McGrath, Kathleen E, Jaen, Juan C, Schall, Thomas J

“…Since the discovery that CXCR7 binds to CXCL12/SDF-1α, the role of CXCR7 in CXCL12-mediated biological processes has been under intensive scrutiny. However,…”
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Nonspecific CXCR7 antibodies by Berahovich, Robert D, Penfold, Mark E.T, Schall, Thomas J

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Differences in CXCR7 protein expression on rat versus mouse and human splenic marginal zone B cells by Berahovich, Robert D, Penfold, Mark E.T, Miao, Zhenhua, Walters, Matthew J, Jaen, Juan C, Schall, Thomas J

“…Highlights • We analyzed CXCR7 expression on marginal zone B cells from rat, human and mouse. • We used sensitive flow cytometry and tyramide-based…”
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CXCR7 protein expression correlates with elevated mmp-3 secretion in breast cancer cells by ZABEL, BRIAN A, MIAO, ZHENHUA, LAI, NU L, WANG, YU, LEWÉN, SUSANNA, BERAHOVICH, ROBERT D, JAÉN, JUAN C, SCHALL, THOMAS J

“…Metastatic breast cancer is the leading cause of cancer-related death in women worldwide and, despite recent therapeutic advances, the disease remains…”
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Expression of CXCR7, CXCR4, CXCR3 and their chemokine ligands in glioblastoma by Berahovich, Robert D., Walters, Matthew J., Sullivan, Timothy J., Kohrt, Holbrook Edwin, Karamchandani, Jason, Jaen, Juan C., Schall, Thomas J.

“…Abstract only 2043 Background: The chemokine receptors CXCR4 and CXCR7, and their shared ligand CXCL12/SDF-1, have been implicated in multiple aspects of…”
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Endothelial expression of CXCR 7 and the regulation of systemic CXCL 12 levels by Berahovich, Robert D., Zabel, Brian A., Lewén, Susanna, Walters, Matthew J., Ebsworth, Karen, Wang, Yu, Jaen, Juan C., Schall, Thomas J.

“…Summary The concentration of CXCL 12/ SDF ‐1 in the bloodstream is tightly regulated, given its central role in leucocyte and stem/progenitor cell egress from…”
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