Search Results - "Bequet, Monica"

Oncogenes and tumor angiogenesis: The HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner by LOPEZ-OCEJO, Omar, VILORIA-PETIT, Alicia, BEQUET-ROMERO, Monica, MUKHOPADHYAY, Debabrata, RAK, Janusz, KERBEL, Robert S

“…Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of…”
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Chimeric Antigen by the Fusion of SARS-CoV-2 Receptor Binding Domain with the Extracellular Domain of Human CD154: A Promising Improved Vaccine Candidate by Ávalos, Ileanet, Lao, Thailin, Rodríguez, Elsa María, Zamora, Yasser, Rodríguez, Alianet, Ramón, Ailyn, Lemos, Gilda, Cabrales, Ania, Bequet-Romero, Monica, Casillas, Dionne, Andújar, Ivan, Espinosa, Luis Ariel, González, Luis Javier, Alvarez, Yanitza, Carpio, Yamila, Estrada, Mario Pablo

“…COVID-19 is a respiratory viral disease caused by a new coronavirus called SARS-CoV-2. This disease has spread rapidly worldwide with a high rate of morbidity…”
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Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF by Sánchez Ramírez, Javier, Morera Díaz, Yanelys, Bequet-Romero, Mónica, Ayala Ávila, Marta

“…CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific…”
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Does VEGF-targeted active immunotherapy induce complete abrogation of platelet VEGF levels? by Sánchez Ramírez, Javier, Bequet-Romero, Mónica, Morera Díaz, Yanelys, Hernández-Bernal, Francisco, Ayala Avila, Marta

“…Vascular endothelial growth factor (VEGF) is involved in physiological angiogenesis, but also is considered one of the key factors that promotes tumor…”
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Specific humoral response in cancer patients treated with a VEGF-specific active immunotherapy procedure within a compassionate use program by Sánchez Ramírez, Javier, Morera Díaz, Yanelys, Bequet-Romero, Mónica, Hernández-Bernal, Francisco, Martín Bauta, Yenima, Selman-Housein Bernal, Katty-Hind, de la Torre Santos, Ana Victoria, Pérez de la Iglesia, Mariela, Trimiño Lorenzo, Lian, Ayala Avila, Marta

“…CIGB-247 is a cancer therapeutic vaccine that uses as antigen a variant of human vascular endothelial growth factor (VEGF) mixed with the bacterially-derived…”
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Evaluation of methodologies to determine the effect of specific active immunotherapy on VEGF levels in phase I clinical trial patients with advanced solid tumors by Sánchez Ramírez, Javier, Bequet-Romero, Mónica, Morera Díaz, Yanelys, Hernández-Bernal, Francisco, de la Torre Santos, Ana, Selman-Housein Bernal, Katty-Hind, Martín Bauta, Yenima, Bermúdez Badell, Cimara H., Limonta Fernández, Miladys, Ayala Avila, Marta

“…Two phase I clinical trials were conducted to evaluate, among other parameters, the humoral response elicited by a vascular endothelial growth factor…”
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Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants by Rodríguez, Meilyn, Pérez, Lincidio, Gavilondo, Jorge V, Garrido, Greta, Bequet-Romero, Mónica, Hernández, Ignacio, Huerta, Vivian, Cabrera, Gleysin, Pérez, Marlene, Ramos, Osmani, Leyva, René, León, Mariela, Ramos, Pedro Luis, Triguero, Ada, Hernández, Abel, Sánchez, Belinda, Ayala, Marta, Soto, Jeny, González, Ernesto, Mendoza, Osmani, Tiel, Kenia, Pujol, Merardo

“…A broad variety of foreign genes can be expressed in transgenic plants, which offer the opportunity for large-scale production of pharmaceutical proteins, such…”
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Nasalferon, a new nasal formulation of IFNα2b, modulates cellular and molecular elements associated with an antiviral response in mucosa and blood by Vázquez-Blomquist, Dania, Bequet-Romero, Mónica, Mendoza-Marí, Yssel, Lemos, Gilda, Valdés, Iris, Canaán-Haden Ayala, Camila, Gonzáles Moya, Isabel, Martínez Rosales, Ricardo, Freyre Corrales, Giselle, Guillén-Nieto, Gerardo

“…We conducted an experimental protocol with a nasal recombinant IFNα-2b formulation (Nasalferon) in 12 healthy volunteers who received 1 MIU per nostril twice a…”
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CIGB-258, péptido inhibidor de la hiperinflamación en pacientes con COVID-19 by María del Carmen Domínguez Horta, Rafael Venegas Rodríguez, Gerardo Guillén Nieto, Gillian Martínez Donato, Mabel Hernández Cedeño, Mónica Bequet Romero, Rubén Peña Ruiz, Raúl Santana Sánchez, Luis Javier González, Ania Cabrales, Gabriel Padrón, Leticia Rosario Cruz, Idelsis Esquivel Moynelo

“…Introducción. El CIGB-258 es un péptido, cuyo mecanismo de acción se ha asociado con la inhibición de la inflamación. El presente trabajo tiene como objetivo…”
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Prophylactic naked DNA vaccination with the human vascular endothelial growth factor induces an anti-tumor response in C57Bl/6 mice by BEQUET-ROMERO, Monica, AYALA, Marta, ACEVEDO, Boris E, GALBAN RODRIGUEZ, Ernesto, LOPEZ OCEJO, Omar, TORRENS, Isis, GAVILONDO, Jorge V

“…Passive immunotherapy against soluble pro-angiogenic factors and/or their receptors in endothelial cells has become a promising approach in cancer…”
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Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine by Morera, Yanelys, Sánchez, Javier, Bequet-Romero, Mónica, Selman-Housein, Katty-Hind, de la Torre, Ana, Hernández-Bernal, Francisco, Martín, Yenima, Garabito, Acralys, Piñero, Jesús, Bermúdez, Cimara, de la Torre, Josué, Ayala, Marta, Gavilondo, Jorge V

“…Highlights • Specific immune response after chronic immunization with CIGB-247 was studied. • We evaluated eight patients after three years of vaccinations. •…”
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Murine monoclonal antibodies against RBD of the SARS-CoV-2 spike protein as useful analytical tools for subunit vaccine development and clinical trials by Blanco, Omar R., Dorta, Dayamí, Hernández, Carlos A., Abreu, Daymí, Domínguez, Andy G., Luna, Yaramis, Valdivia, Onel, Pérez-Bernal, Maylín, Tamayo, Celia, Lemos, Gilda, Pasarón, Ivis M., Pérez, Joel J., Benítez, Liudmila, Bequet-Romero, Mónica, Fragas, Anitza, Cabrera, Yeosvany, Pérez, Enrique R.

“…COVID-19 pandemic poses a serious threat to human health; it has completely disrupted global stability, making vaccine development an important goal to…”
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HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis by Fleites, Yoel A, Aguiar, Jorge, Cinza, Zurina, Bequet, Monica, Marrero, Elieser, Vizcaíno, Maritania, Esquivel, Idelsis, Diaz, Marisol, Sin-Mayor, Adriana, Garcia, Maura, Martinez, Sara M, Beato, Abrahan, Galarraga, Ana G, Mendoza-Mari, Yssel, Valdés, Iris, García, Gerardo, Lemos, Gilda, González, Isabel, Canaán-Haden, Camila, Figueroa, Nelvis, Oquendo, Rachel, Akbar, Sheikh Mf, Mahtab, Mamun A, Uddin, Mohammad H, Guillén, Gerardo E, Muzio, Verena L, Pentón, Eduardo, Aguilar, Julio C

“…More than 180 million people have been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and more than 4 million coronavirus…”
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Biologically active vascular endothelial growth factor as a bacterial recombinant glutathione S-transferase fusion protein by Morera, Yanelys, Lamdan, Humberto, Bequet, Mónica, Ayala, Marta, Rojas, Gertrudis, Muñoz, Yasmiana, Gavilondo, Jorge V.

“…Human VEGF121 (vascular endothelial growth factor isoform 121) was produced as a recombinant fusion protein with GST (glutathione S‐transferase) in Escherichia…”
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Specific active immunotherapy with the HEBERSaVax VEGF-based cancer vaccine: From bench to bedside by Morera-Díaz, Yanelys, Gavilondo, Jorge V., Bequet-Romero, Mónica, Sánchez Ramírez, Javier, Hernández-Bernal, Francisco, Selman-Housein, Katty-Hind, Perez, Lincidio, Ayala-Ávila, Marta

“…HEBERSaVax is a cancer therapeutic vaccine candidate based on the combination of a recombinant antigen representative of human vascular endothelial growth…”
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Targeting the hydrophilic regions of recombinant proteins by MS via in-solution buffer-free trypsin digestion by Betancourt, Lázaro H, Espinosa, Luis A, Ramos, Yassel, Bequet-Romero, Mónica, Rodríguez, Elías N, Sánchez, Aniel, Marko-Varga, Gyorgy, González, Luis J, Besada, Vladimir

“…A desalting step using reversed phase chromatography is a common practice prior to mass spectrometry analysis of proteolytic digests in spite of the…”
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Systemic translation of locally infiltrated epidermal growth factor in diabetic lower extremity wounds by García‐Ojalvo, Ariana, Berlanga Acosta, Jorge, Figueroa‐Martínez, Alain, Béquet‐Romero, Mónica, Mendoza‐Marí, Yssel, Fernández‐Mayola, Maday, Fabelo‐Martínez, Amirelia, Guillén‐Nieto, Gerardo

“…Diabetic foot ulcer is one of the most frightened diabetic complications leading to amputation disability and early mortality. Diabetic wounds exhibit a…”
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A multivalent recombinant antibody fragment specific for carcinoembryonic antigen by Perez, Lincidio, Ayala, Marta, Pimentel, Gilmara, Bell, Hanssel, Canaán-Haden, Leonardo, Bequet, Mónica, González, Luis Javier, Miranda, Marlen, Ravelo, Rolando, Roque, Lourdes, Acevedo, Boris, Oliva, Juan P., Gavilondo, Jorge V.

“…In the present paper we report the development of a bivalent scFv (single‐chain Fv) antibody fragment, starting from a mouse mAb (monoclonal antibody) specific…”
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CIGB-247: A VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors by Bequet-Romero, Mónica, Morera, Yanelys, Ayala-Ávila, Marta, Ancizar, Julio, Soria, Yordanka, Blanco, Aracelys, Suárez-Alba, Jesús, Gavilondo, Jorge V

“…Highlights ► Antimetastatic effects of a VEGF based active immunotherapy: CIGB-247. ► CIGB-247 is a cancer therapeutic, based on recombinant modified VEGF as…”
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A recombinant SARS-CoV-2 receptor-binding domain expressed in an engineered fungal strain of Thermothelomyces heterothallica induces a functional immune response in mice by Lazo, Laura, Bequet-Romero, Monica, Lemos, Gilda, Musacchio, Alexis, Cabrales, Ania, Bruno, Andy J., Ariel Espinosa, Luis, Saloheimo, Markku, Vitikainen, Marika, Hernández, Amalia, Emalfarb, Mark, Tchelet, Ronen, Suzarte, Edith, Guillén, Gerardo

“…Since the beginning of the COVID-19 pandemic, the development of effective vaccines against this pathogen has been a priority for the scientific community…”
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