Epidemiology of breast cancer in women based on diagnosis data from oncologists and senologists in Algeria

•Mortality rate due to breast cancer reached 3.23% at 12 months in Algeria.•22 new cases per 100,000 inhabitants were identified over 8 months.•Late diagnosis is one of the risks compromising the prognosis of women with a diagnosis of breast cancer where preventive screening measures must be optimis...

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Published in:	Cancer treatment and research communications Vol. 25; p. 100220
Main Authors:	Smaili, F, Boudjella, A, Dib, A, Braikia, S, Zidane, H, Reggad, R, Bendib, A, Abdelouahab, A, Bereksi-Reguig, F, Yekrou, D, Bentouati, A, Filali, T, Chirouf, A, Djehal, N, Mahfouf, H, Mechiat, F, Tadjerouni, H, Sedkaoui, C, Hikem, M, Amber, A, Bouzid, K, Ladjeroud, A, Ghomari, S, Aris, H, Saidi, S, Larhbali, R, Saidi, MA, Haddouche, A, Kedar, M, Bounedjar, A, Talha, S, Benbrahim, W, Ammari, A, Boushaba, A, Rabah, A, Ameziane, N, Benabdallah, F, Djedi, H, Kouadri, N, Bensalem, A, Djeghim, S, Oukkal, M, Hadjam, F, Larbaoui, B, Rekai, K, Azzouz, N, Badaoui, A, Abid, M, Abada, M, Moussei, A, Benmehidi, F, Benzidane, N, Boualga, K, Mesli, S
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 2020 Elsevier
Subjects:	Breast cancer Diagnosis Incidence Mortality Treatment Treatment Mortality CI ECOG SAE Abbreviations: BC Breast cancer HR Diagnosis HER2 Incidence
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Summary:	•Mortality rate due to breast cancer reached 3.23% at 12 months in Algeria.•22 new cases per 100,000 inhabitants were identified over 8 months.•Late diagnosis is one of the risks compromising the prognosis of women with a diagnosis of breast cancer where preventive screening measures must be optimised. Breast cancer (BC) is a major health issue threatening women's life. No reliable epidemiological data on BC diagnosed by oncologists/senologists are available in Algeria. The BreCaReAl study, a non-interventional prospective cohort study, included adult women with confirmed BC in Algeria. Disease incidence, patients and disease characteristics, treatment patterns, and mortality rate were recorded up to 12 months of follow-up. Overall, 1,437 patients were analysed: median age was 48 [41;57] years and 337 (23.5%) women had a family history of BC. BC incidence was 22.3 (95% CI: 21.5; 23.2) cases per 100,000 inhabitants over 8 months. Delayed diagnosis was reported in 400 (29.2%) patients. First line of treatments were mainly chemotherapy and surgery. Twenty-eight serious adverse events were reported including 10 (37.0%) events which led to death. Mortality rate reached 3.2% at 12 months A delayed diagnosis highlights the importance of implementing more effective screening strategies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2468-2942 2468-2942
DOI:	10.1016/j.ctarc.2020.100220