Search Results - "Benz, Christopher"

Ageing, oxidative stress and cancer: paradigms in parallax by Benz, Christopher C, Yau, Christina

“…Ageing is thought to be associated with increased oxidative stress and increased cancer risk. However, recent evidence that breast cancers arising in older…”
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Impact of aging on the biology of breast cancer by Benz, Christopher C

“…Abstract Breast cancer is a heterogeneous malignancy; its age-specific incidence profile rises exponentially until menopause and increases more slowly…”
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A multigene predictor of metastatic outcome in early stage hormone receptor-negative and triple-negative breast cancer by Yau, Christina, Esserman, Laura, Moore, Dan H, Waldman, Fred, Sninsky, John, Benz, Christopher C

“…Various multigene predictors of breast cancer clinical outcome have been commercialized, but proved to be prognostic only for hormone receptor (HR) subsets…”
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Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies by Mattie, Michael D, Benz, Christopher C, Bowers, Jessica, Sensinger, Kelly, Wong, Linda, Scott, Gary K, Fedele, Vita, Ginzinger, David, Getts, Robert, Haqq, Chris

“…Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a…”
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation by Laberge, Remi-Martin, Sun, Yu, Orjalo, Arturo V., Patil, Christopher K., Freund, Adam, Zhou, Lili, Curran, Samuel C., Davalos, Albert R., Wilson-Edell, Kathleen A., Liu, Su, Limbad, Chandani, Demaria, Marco, Li, Patrick, Hubbard, Gene B., Ikeno, Yuji, Javors, Martin, Desprez, Pierre-Yves, Benz, Christopher C., Kapahi, Pankaj, Nelson, Peter S., Campisi, Judith

“…The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates…”
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Breast Cancer Metastasis Suppressor 1 Up-regulates miR-146, Which Suppresses Breast Cancer Metastasis by HURST, Douglas R, EDMONDS, Mick D, SCOTT, Gary K, BENZ, Christopher C, VAIDYA, Kedar S, WELCH, Danny R

“…Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to…”
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Reduced cardiovascular risks in women with endometriosis or polycystic ovary syndrome carrying a common functional IGF1R variant by Powell, Mark J, Fuller, Sophia, Gunderson, Erica P, Benz, Christopher C

“…Abstract STUDY QUESTION Is the increased future cardiovascular risk seen in women with endometriosis or polycystic ovary syndrome (PCOS) mitigated by…”
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Coordinate Suppression of ERBB2 and ERBB3 by Enforced Expression of Micro-RNA miR-125a or miR-125b by Scott, Gary K., Goga, Andrei, Bhaumik, Dipa, Berger, Crystal E., Sullivan, Christopher S., Benz, Christopher C.

“…Deregulation of micro-RNAs (miRNAs) is emerging as a major aspect of cancer etiology because their capacity to direct the translation and stability of targeted…”
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Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas by Huo, Dezheng, Hu, Hai, Rhie, Suhn K, Gamazon, Eric R, Cherniack, Andrew D, Liu, Jianfang, Yoshimatsu, Toshio F, Pitt, Jason J, Hoadley, Katherine A, Troester, Melissa, Ru, Yuanbin, Lichtenberg, Tara, Sturtz, Lori A, Shelley, Carl S, Benz, Christopher C, Mills, Gordon B, Laird, Peter W, Shriver, Craig D, Perou, Charles M, Olopade, Olufunmilayo I

“…African Americans have the highest breast cancer mortality rate. Although racial difference in the distribution of intrinsic subtypes of breast cancer is…”
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Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype by Wiley, Christopher D., Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V., Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R., Campisi, Judith

“…Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide,…”
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Monotonic and Fatigue Behavior of EBM Manufactured Ti-6Al-4V Solid Samples: Experimental, Analytical and Numerical Investigations by Radlof, Wiebke, Benz, Christopher, Heyer, Horst, Sander, Manuela

“…The present study aims to carry out an experimental, analytical and numerical investigation of the monotonic and fatigue performance of electron beam melted…”
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Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration by Teramayi, Fadzai, Bons, Joanna, Scott, Madeleine, Scott, Gary K., Loureiro, Ashley, Lopez-Ramirez, Alejandro, Schilling, Birgit, Ellerby, Lisa M., Benz, Christopher C.

“…[Display omitted] •Treatment of HD or control mice with N-propargylglycine (N-PPG) induced mitohormesis.•Metabolomics revealed increased levels of proline,…”
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Rapid alteration of MicroRNA levels by histone deacetylase inhibition by SCOTT, Gary K, MATTIE, Michael D, BERGER, Crystal E, BENZ, Stephen C, BENZ, Christopher C

“…Improved understanding of the molecular mechanisms by which small-molecule inhibitors of histone deacetylases (HDAC) induce programs, such as cellular…”
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Targeting Mitochondrial Proline Dehydrogenase with a Suicide Inhibitor to Exploit Synthetic Lethal Interactions with p53 Upregulation and Glutaminase Inhibition by Scott, Gary K, Yau, Christina, Becker, Beatrice C, Khateeb, Sana, Mahoney, Sophia, Jensen, Martin Borch, Hann, Byron, Cowen, Bryan J, Pegan, Scott D, Benz, Christopher C

“…Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane flavoprotein linked to electron transport for anaplerotic glutamate and ATP…”
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Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer by Lindström, Linda S, Yau, Christina, Czene, Kamila, Thompson, Carlie K, Hoadley, Katherine A, Van't Veer, Laura J, Balassanian, Ron, Bishop, John W, Carpenter, Philip M, Chen, Yunn-Yi, Datnow, Brian, Hasteh, Farnaz, Krings, Gregor, Lin, Fritz, Zhang, Yanhong, Nordenskjöld, Bo, Stål, Olle, Benz, Christopher C, Fornander, Tommy, Borowsky, Alexander D, Esserman, Laura J

“…Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors…”
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Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer by Zhou, Yamei, Yau, Christina, Gray, Joe W, Chew, Karen, Dairkee, Shanaz H, Moore, Dan H, Eppenberger, Urs, Eppenberger-Castori, Serenella, Benz, Christopher C

“…Signaling pathways that converge on two different transcription factor complexes, NFkappaB and AP-1, have been identified in estrogen receptor (ER)-positive…”
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Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models by Kirpotin, Dmitri B, Drummond, Daryl C, Shao, Yi, Shalaby, M Refaat, Hong, Keelung, Nielsen, Ulrik B, Marks, James D, Benz, Christopher C, Park, John W

“…We describe evidence for a novel mechanism of monoclonal antibody (MAb)-directed nanoparticle (immunoliposome) targeting to solid tumors in vivo…”
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Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N‑Propargylglycine by Tanner, John J., Ji, Juan, Bogner, Alexandra N., Scott, Gary K., Patel, Sagar M., Seravalli, Javier, Gates, Kent S., Benz, Christopher C., Becker, Donald F.

“…The flavoenzyme proline dehydrogenase (PRODH) catalyzes the first step of proline catabolism, the oxidation of l-proline to Δ1-pyrroline-5-carboxylate. The…”
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Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity by Bons, Joanna, Tadeo, Ada, Scott, Gary K., Teramayi, Fadzai, Tanner, John J., Schilling, Birgit, Benz, Christopher C., Ellerby, Lisa M.

“…N-propargylglycine prevents 4-hydroxyproline catabolism in mouse liver and kidney. N-propargylglycine is a novel suicide inhibitor of PRODH2 and induces…”
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Cancer and Cardiovascular Risk in Women With Hypertensive Disorders of Pregnancy Carrying a Common IGF1R Variant by Powell, Mark J., Dufault, Suzanne M., Gunderson, Erica P., Benz, Christopher C.

“…To evaluate the impact of insulin-like growth factor 1 receptor variant rs2016347 on the risk for breast and nonbreast cancers and cardiovascular disease in…”
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