Search Results - "Benyamini, Hadar"

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation by Malakar, Pushkar, Shilo, Asaf, Mogilevsky, Adi, Stein, Ilan, Pikarsky, Eli, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Zong, Xinying, Prasanth, Kannanganattu V, Karni, Rotem

“…Several long noncoding RNAs (lncRNA) are abrogated in cancer but their precise contributions to oncogenesis are still emerging. Here we report that the lncRNA…”
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Replicative Stress Coincides with Impaired Nuclear DNA Damage Response in COX4-1 Deficiency by Douiev, Liza, Miller, Chaya, Keller, Guy, Benyamini, Hadar, Abu-Libdeh, Bassam, Saada, Ann

“…Cytochrome oxidase (COX), a multimeric protein complex, is the final electron acceptor in the mitochondrial electron transfer chain. Primary COX deficiency,…”
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Amyloidogenic light chains impair plasma cell survival by Pick, Marjorie, Lebel, Eyal, Elgavish, Sharona, Benyamini, Hadar, Nevo, Yuval, Hertz, Rachel, Bar-Tana, Jacob, Rognoni, Paola, Merlini, Giampaolo, Gatt, Moshe E

“…Systemic light chain amyloidosis (AL) is a clonal plasma cell disorder characterized by the deposition of misfolded immunoglobulin light chains (LC) as…”
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Chronic Intermittent Hypoxia during Sleep Causes Browning of Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in Mice by Dahan, Tehila, Nassar, Shahd, Yajuk, Olga, Steinberg, Eliana, Benny, Ofra, Abudi, Nathalie, Plaschkes, Inbar, Benyamini, Hadar, Gozal, David, Abramovitch, Rinat, Gileles-Hillel, Alex

“…Obstructive sleep apnea (OSA) is a highly prevalent condition, characterized by intermittent hypoxia (IH), sleep disruption, and altered autonomic nervous…”
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Asynchronous Pattern of MAPKs' Activity during Aging of Different Tissues and of Distinct Types of Skeletal Muscle by Gilad, Nechama, Mohanam, Manju Payini, Darlyuk-Saadon, Ilona, Heng, C K Matthew, Plaschkes, Inbar, Benyamini, Hadar, Berezhnoy, Nikolay V, Engelberg, David

“…The MAPK p38α was proposed to be a prominent promoter of skeletal muscle aging. The skeletal muscle tissue is composed of various muscle types, and it is not…”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease by Guy, Reut, Herman, Shay, Benyamini, Hadar, Ben-Zur, Tali, Kobo, Hila, Pasmanik-Chor, Metsada, Yaacobi, Dafna, Barel, Eric, Yagil, Chana, Yagil, Yoram, Offen, Daniel

“…Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been employed in the past decade as therapeutic agents in various diseases, including…”
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Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles Modulate Apoptosis, TNF Alpha and Interferon Gamma Response Gene mRNA Expression in T Lymphocytes by Fracchia, Andrea, Khare, Drirh, Da’na, Samar, Or, Reuven, Buxboim, Amnon, Nachmias, Boaz, Barkatz, Claudine, Golan-Gerstl, Regina, Tiwari, Swasti, Stepensky, Polina, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Almogi-Hazan, Osnat, Avni, Batia

“…Recent studies have highlighted the therapeutic potential of small extracellular bodies derived from mesenchymal stem cells (MSC-sEVs) for various diseases,…”
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AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line by Yehezkel, Adi S., Abudi, Nathalie, Nevo, Yuval, Benyamini, Hadar, Elgavish, Sharona, Weinstock, Marta, Abramovitch, Rinat

“…Non-alcoholic steatohepatitis (NASH) is an aggressive form of fatty liver disease with hepatic inflammation and fibrosis for which there is currently no drug…”
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Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis by Paldor, Mor, Levkovitch‐Siany, Orr, Eidelshtein, Dana, Adar, Revital, Enk, Claes D, Marmary, Yitzhak, Elgavish, Sharona, Nevo, Yuval, Benyamini, Hadar, Plaschkes, Inbar, Klein, Shiri, Mali, Alex, Rose‐John, Stefan, Peled, Amnon, Galun, Eithan, Axelrod, Jonathan H

“…Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular…”
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Using peptides to study protein-protein interactions by Benyamini, Hadar, Friedler, Assaf

“…Protein-protein interactions (PPIs) govern all aspects of cell function and, as such, are a major target for research and therapeutic intervention. A major…”
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Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice by Stokar, Joshua, Gurt, Irina, Cohen-Kfir, Einav, Yakubovsky, Oran, Hallak, Noa, Benyamini, Hadar, Lishinsky, Natan, Offir, Neta, Tam, Joseph, Dresner-Pollak, Rivka

“…Menopause is associated with visceral adiposity, hepatic steatosis and increased risk for cardiovascular disease. As estrogen replacement therapy is not…”
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Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency by Douiev, Liza, Miller, Chaya, Ruppo, Shmuel, Benyamini, Hadar, Abu-Libdeh, Bassam, Saada, Ann

“…Cytochrome- -oxidase (COX) subunit 4 (COX4) plays important roles in the function, assembly and regulation of COX (mitochondrial respiratory complex 4), the…”
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Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression by Guedj, Avital, Geiger-Maor, Anat, Galun, Eithan, Benyamini, Hadar, Nevo, Yaval, Elgavish, Sharona, Amsalem, Hagai, Rachmilewitz, Jacob

“…Aging is associated with progressive decline in cell function and with increased damage to macromolecular components. DNA damage, in the form of double-strand…”
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Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2 by Katz, Chen, Benyamini, Hadar, Rotem, Shahar, Lebendiker, Mario, Danieli, Tsafi, Iosub, Anat, Refaely, Hadar, Dines, Monica, Bronner, Vered, Bravman, Tsafrir, Shalev, Deborah E, Rüdiger, Stefan, Friedler, Assaf

“…We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin…”
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The Structure and Interactions of the Proline-rich Domain of ASPP2 by Rotem, Shahar, Katz, Chen, Benyamini, Hadar, Lebendiker, Mario, Veprintsev, Dmitry, Rüdiger, Stefan, Danieli, Tsafi, Friedler, Assaf

“…ASPP2 is a pro-apoptotic protein that stimulates the p53-mediated apoptotic response. The C terminus of ASPP2 contains ankyrin (Ank) repeats and a SH3 domain,…”
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Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions by Kolodkin-Gal, Dror, Roitman, Lior, Ovadya, Yossi, Azazmeh, Narmen, Assouline, Benjamin, Schlesinger, Yehuda, Kalifa, Rachel, Horwitz, Shaul, Khalatnik, Yonatan, Hochner-Ger, Anna, Imam, Ashraf, Demma, Jonathan Abraham, Winter, Eitan, Benyamini, Hadar, Elgavish, Sharona, Khatib, Areej As, Meir, Karen, Atlan, Karine, Pikarsky, Eli, Parnas, Oren, Dor, Yuval, Zamir, Gideon, Ben-Porath, Ittai, Krizhanovsky, Valery

“…Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine…”
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Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate by Hutchings, Carmel, Nuriel, Yarden, Lazar, Daniel, Kohl, Ayelet, Muir, Elizabeth, Genin, Olga, Cinnamon, Yuval, Benyamini, Hadar, Nevo, Yuval, Sela-Donenfeld, Dalit

“…The interplay between neural progenitors and stem cells (NPSCs), and their extracellular matrix (ECM) is a crucial regulatory mechanism that determines their…”
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UMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes by Soni, Awakash, Klebanov-Akopyan, Olga, Erben, Esteban, Plaschkes, Inbar, Benyamini, Hadar, Mitesser, Vera, Harel, Amnon, Yamin, Katereena, Onn, Itay, Shlomai, Joseph

“…Abstract Universal Minicircle Sequence binding proteins (UMSBPs) are CCHC-type zinc-finger proteins that bind the single-stranded G-rich UMS sequence,…”
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Modeling sex differences in humans using isogenic induced pluripotent stem cells by Waldhorn, Ithai, Turetsky, Tikva, Steiner, Debora, Gil, Yaniv, Benyamini, Hadar, Gropp, Michal, Reubinoff, Benjamin E.

“…Biological sex is a fundamental trait influencing development, reproduction, pathogenesis, and medical treatment outcomes. Modeling sex differences is…”
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Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL-6 trans-signaling by Rosenberg, Nofar, Van Haele, Matthias, Lanton, Tali, Brashi, Neta, Bromberg, Zohar, Adler, Hanan, Giladi, Hilla, Peled, Amnon, Goldenberg, Daniel S., Axelrod, Jonathan H., Simerzin, Alina, Chai, Chofit, Paldor, Mor, Markezana, Auerlia, Yaish, Dayana, Shemulian, Zohar, Gross, Dvora, Barnoy, Shanny, Gefen, Maytal, Amran, Osher, Claerhout, Sofie, Fernández-Vaquero, Mirian, García-Beccaria, María, Heide, Danijela, Shoshkes-Carmel, Michal, Schmidt Arras, Dirk, Elgavish, Sharona, Nevo, Yuval, Benyamini, Hadar, Tirnitz-Parker, Janina E.E., Sanchez, Aranzazu, Herrera, Blanca, Safadi, Rifaat, Kaestner, Klaus H., Rose-John, Stefan, Roskams, Tania, Heikenwalder, Mathias, Galun, Eithan

“…Primary liver cancers include hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (CCA) and combined HCC-CCA tumors (cHCC-CCA). It has been…”
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