Search Results - "Benya, Richard V."

Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia by Carroll, Robert E, Benya, Richard V, Turgeon, Danielle Kim, Vareed, Shaiju, Neuman, Malloree, Rodriguez, Luz, Kakarala, Madhuri, Carpenter, Philip M, McLaren, Christine, Meyskens, Jr, Frank L, Brenner, Dean E

“…Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic effects in vitro and in animal models, including preventing aberrant…”
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Lubiprostone Activates Cl⁻ Secretion via cAMP Signaling and Increases Membrane CFTR in the Human Colon Carcinoma Cell Line, T84 by Ao, Mei, Venkatasubramanian, Jayashree, Boonkaewwan, Chaiwat, Ganesan, Nivetha, Syed, Asma, Benya, Richard V, Rao, Mrinalini C

“…Background Lubiprostone, used clinically (b.i.d.) to treat constipation, has been reported to increase transepithelial Cl⁻ transport in T84 cells by activating…”
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Expression of Vitamin D Receptor and 25-Hydroxyvitamin D3-1α-Hydroxylase in Normal and Malignant Human Colon by MATUSIAK, Damien, MURILLO, Genoveva, CARROLL, Robert E, MEHTA, Rajendra G, BENYA, Richard V

“…Considerable evidence exists to support the use of vitamin D to prevent and/or treat colorectal cancer. However, the routine use of bioactive vitamin D,…”
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Aberrant Crypt Focus Size Predicts Distal Polyp Histopathology by Kim, Jae, Ng, Jennie, Arozulllah, Ahsan, Ewing, Ronald, Llor, Xavier, Carroll, Robert E, Benya, Richard V

“…Aberrant crypt foci (ACF) are the earliest histopathologic lesion associated with colorectal cancer. ACFs are commonly used as a surrogate marker for…”
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Quantitative Immunohistochemistry by Measuring Cumulative Signal Strength Accurately Measures Receptor Number by Matkowskyj, Kristina A, Cox, Randal, Jensen, Robert T, Benya, Richard V

“…We previously demonstrated that quantitative immunohistochemistry (Q-IHC) performed by measuring the cumulative signal strength of the digital file encoding an…”
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Quantitative Immunohistochemistry by Measuring Cumulative Signal Strength Using Commercially Available Software Photoshop and Matlab by Matkowskyj, Kristina A, Schonfeld, Dan, Benya, Richard V

“…Currently available techniques for performing quantitative immunohistochemistry (Q-IHC) rely upon pixel-counting algorithms and therefore cannot provide…”
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Consequence of Gastrin-Releasing Peptide Receptor Activation in a Human Colon Cancer Cell Line:  A Proteomic Approach by Ruginis, Tom, Taglia, Lauren, Matusiak, Damien, Lee, Bao-Shiang, Benya, Richard V

“…Gastrin-releasing peptide (GRP) and its receptor (GRPR) are aberrantly up-regulated in colon cancer. When expressed, they act as morphogens, retaining tumor…”
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Estrogen receptor-β protects against colitis-associated neoplasia in mice by Saleiro, Diana, Murillo, Genoveva, Benya, Richard V., Bissonnette, Marc, Hart, John, Mehta, Rajendra G.

“…Estrogen receptor‐beta (ERβ) has been suggested to exert anti‐inflammatory and anti‐tumorigenic effects in the colon, providing a translational potential to…”
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Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon by Matusiak, Damien, Glover, Sarah, Nathaniel, Rajkumar, Matkowskyj, Kristina, Yang, Jianxin, Benya, Richard V

“…Bombesin-like peptides are uniformly thought to act as mitogens in cancer. Yet by studying human tissues, we have recently shown that bombesin and its…”
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CYP27A1 and CYP24 Expression as a Function of Malignant Transformation in the Colon by Matusiak, Damien, Benya, Richard V

“…Vitamin D deficiency is strongly associated with the risk of developing colorectal cancer (CRC). Because of the propensity of bioactive 1,25-dihydroxyvitamin…”
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Transient upregulation of GRP and its receptor critically regulate colon cancer cell motility during remodeling by Glover, Sarah, Nathaniel, Rajkumar, Shakir, Lubna, Perrault, Cecile, Anderson, Rebecca K, Tran-Son-Tay, Roger, Benya, Richard V

“…Gastrin-releasing peptide (GRP) is typically viewed as a growth factor in cancer. However, we have suggested that in colon cancer, GRP acts primarily as a…”
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Chemopreventive efficacy of 25-hydroxyvitamin D3 in colon cancer by Murillo, Genoveva, Matusiak, Damien, Benya, Richard V., Mehta, Rajendra G.

“…Recently, it has been reported that 25-hydroxyvitamin D3-1α-hydroxylase [1α(OH)ase, CYP27B1], required to convert non-toxic 25-hyxdroxyvitamin D3 [25(OH)D3] to…”
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Allelic loss of the gene for the GPX1 selenium-containing protein is a common event in cancer by Hu, Yajun, Benya, Richard V, Carroll, Robert E, Diamond, Alan M

“…Selenium has been shown to reduce cancer incidence in animal models and more recent data indicate that it may be protective in humans as well. However, little…”
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GRP-induced up-regulation of Hsp72 promotes CD16+/94+ natural killer cell binding to colon cancer cells causing tumor cell cytolysis by Taglia, Lauren, Matusiak, Damien, Benya, Richard V.

“…Gastrin-releasing peptide (GRP) and its receptor (GRPR) are not normally expressed by epithelial cells lining the adult human colon. However post malignant…”
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Importance of amino acids of the central portion of the second intracellular loop of the gastrin-releasing Peptide receptor for phospholipase C activation, internalization, and chronic down-regulation by Schumann, Michael, Nakagawa, Tomoo, Mantey, Samuel A, Tokita, Kenji, Venzon, David J, Hocart, Simon J, Benya, Richard V, Jensen, Robert T

“…Little is known about the function of the central portion of the second intracellular loop (i2 loop) of peptide receptors in activation of downstream pathways…”
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Gastrin-releasing peptide mediates its morphogenic properties in human colon cancer by upregulating intracellular adhesion protein-1 (ICAM-1) via focal adhesion kinase by Taglia, Lauren, Matusiak, Damien, Matkowskyj, Kristina A, Benya, Richard V

“…Gastrin-releasing peptide (GRP) and its receptor (GRPR) act as morphogens when expressed in colorectal cancer (CRC), promoting the assumption of a better…”
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T1997 GRP-Induced Activation of Heterochromatin Protein 1hsβ (Hp1β) Decreases Colon Cancer Invasiveness by Tell, Robert, Blunier, Adam, Benya, Richard V

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Galanin contributes to the excess colonic fluid secretion observed in dextran sulfate sodium murine colitis by Matkowskyj, Kristina A., Nathaniel, Rajkumar, Prasad, Roli, Weihrauch, Dirk, Rao, Mrinalini, Benya, Richard V.

“…Galanin is present in enteric nerves lining the gastrointestinal (GI) tract where it is normally involved in regulating intestinal motility by binding to the…”
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Expression of GRP and its receptor is associated with improved survival in patients with colon cancer by Rivera, Claudio A, Ahlberg, Ned C, Taglia, Lauren, Kumar, Mayank, Blunier, Adam, Benya, Richard V

“…Epithelial cells lining the adult human colon do not normally express gastrin releasing peptide (GRP) or its receptor (GRPR), but both can be up regulated post…”
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Gastrin-Releasing Peptide Signaling Alters Colon Cancer Invasiveness via Heterochromatin Protein 1Hsβ by Tell, Robert, Rivera, Claudio A, Eskra, Jillian, Taglia, Lauren N, Blunier, Adam, Tian Wang, Q, Benya, Richard V

“…Epithelial cells lining the adult colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR). In contrast, GRP/GRPR can be aberrantly…”
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