Search Results - "Benya, R. V."

International Union of Pharmacology. LXVIII. Mammalian Bombesin Receptors: Nomenclature, Distribution, Pharmacology, Signaling, and Functions in Normal and Disease States by Jensen, R T, Battey, J F, Spindel, E R, Benya, R V

“…The mammalian bombesin receptor family comprises three G protein-coupled heptahelical receptors: the neuromedin B (NMB) receptor (BB 1 ), the gastrin-releasing…”
Get full text

Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer by Murillo, G., Nagpal, V., Tiwari, N., Benya, R.V., Mehta, R.G.

“…Many chronic inflammatory diseases are associated with increased risk of developing cancer. In the colon, strong support for a link between chronic…”
Get full text

Age-dependent differences in galanin-dependent colonic fluid secretion after infection with Salmonella typhimurium by Matkowskyj, K, Royan, S V, Blunier, A, Hecht, G, Rao, M, Benya, R V

“…Epithelial cells lining the colon do not normally express galanin type 1 receptors (Gal1Rs). However, subsequent to infection with enteric pathogens such as…”
Get more information

Zollinger-Ellison syndrome can be the initial endocrine manifestation in patients with multiple endocrine neoplasia-type I by Benya, R V, Metz, D C, Venzon, D J, Fishbeyn, V A, Strader, D B, Orbuch, M, Jensen, R T

“…To determine whether patients with multiple endocrine neoplasia type I (MEN-I) can initially present with Zollinger-Ellison syndrome (ZES), and to learn…”
Get more information

Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization by BENYA, R. V, FATHI, Z, BATTEY, J. F, JENSEN, R. T

“…Most seven-transmembrane G-protein-coupled receptors are rapidly internalized after binding agonist, but the general amino acid recognition sequences mediating…”
Get full text

Why are internal medicine residents at university medical centers not pursuing fellowship training in gastroenterology? A survey analysis by Benya, Richard V

“…The decrease in available GI fellowship positions appears to be associated with a disproportionate decrease in the quality of applicants. Thus, the aims of…”
Get full text

Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors by Benya, R V, Wada, E, Battey, J F, Fathi, Z, Wang, L H, Mantey, S A, Coy, D H, Jensen, R T

“…The receptor that interacts with the mammalian bombesin-related peptide neuromedin B (NMB) is ubiquitous in the gastrointestinal tract and central nervous…”
Get more information

A prospective study of intraoperative methods to diagnose and resect duodenal gastrinomas by SUGG, S. L, NORTON, J. A, FRAKER, D. L, METZ, D. C, PISEGNA, J. R, FISHBEYN, V, BENYA, R. V, SHAWKER, T. H, DOPPMAN, J. L, JENSEN, R. T

“…This study determined, prospectively, whether duodenotomy (DX) should be routinely performed in explorations for patients with Zollinger-Ellison syndrome…”
Get full text

Expression and characterization of cloned human bombesin receptors by Benya, R V, Kusui, T, Pradhan, T K, Battey, J F, Jensen, R T

“…Little is known about the pharmacology or cell biology of human bombesin (Bn) receptors, because they are usually present at low levels and both subtypes are…”
Get more information

Assessment and prediction of long-term cure in patients with the Zollinger-Ellison syndrome : the best approach by FISHBEYN, V. A, NORTON, J. A, BENYA, R. V, PISEGNA, J. R, VENZON, D. J, METZ, D. C, JENSEN, R. T

“…To identify the best method for determining freedom from disease after gastrinoma resection and for predicting long-term disease-free status in patients with…”
Get full text

Desensitization of neuromedin B receptors (NMB-R) on native and NMB-R-transfected cells involves down-regulation and internalization by BENYA, R. V, KUSUI, T, SHIKADO, F, BATTEY, J. F, JENSEN, R. T

“…The receptor for neuromedin B (NMB-R), a mammalian bombesin-related peptide, is widely distributed in the central nervous system and gastrointestinal tract…”
Get full text

Gastrin-releasing peptide receptor-induced internalization, down-regulation, desensitization, and growth: possible role for cyclic AMP by Benya, R V, Fathi, Z, Kusui, T, Pradhan, T, Battey, J F, Jensen, R T

“…Stimulation of the gastrin-releasing peptide receptor (GRP-R) in Swiss 3T3 cells resembles that of a number of other recently described G protein-coupled…”
Get more information

Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460 by Ferris, H A, Carroll, R E, Rasenick, M M, Benya, R V

“…Gastrin-releasing peptide (GRP) causes multiple effects in humans by activating a specific heptaspanning receptor. Within the gastrointestinal tract, GRP…”
Get full text

The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding by Fathi, Z, Benya, R V, Shapira, H, Jensen, R T, Battey, J F

“…The two bombesin receptor subtypes, neuromedin B (NMB-R) and gastrin releasing peptide (GRP-R) receptors, bind their respective ligands with high affinity. To…”
Get full text

Extent of prevalence and size of flat neoplasms in a heterogeneous population undergoing routine colorectal cancer screening by Kim, J., Rami, P., O'Toole, J., Llor, X., Carroll, R. E., Benya, R. V.

“…Background  The importance of identifying flat colorectal neoplasms is increasingly appreciated, although the extent of prevalence of these lesions in a…”
Get full text

Quantitative Immunohistochemistry by Measuring Cumulative Signal Strength Using Commercially Available Software Photoshop and Matlab by Matkowskyj, Kristina A, Schonfeld, Dan, Benya, Richard V

“…Currently available techniques for performing quantitative immunohistochemistry (Q-IHC) rely upon pixel-counting algorithms and therefore cannot provide…”
Get full text

Fibrin sheath formation surrounding a pulmonary artery catheter sheath: eversion of the sleeve during catheter removal by Benya, R V

Get more information

Electrophysiological characterization of human distal colon epithelium isolated using a novel technique by MARRERO, J. A, OSTROVSKIY, D. A, MATKOWSKYJ, K. A, KOUTSOURIS, S, HECHT, G, BENYA, R. V

“…Electrophysiological studies of human colonic epithelia traditionally have been hampered by the lack of tissue availability and by poor tissue quality. Human…”
Get full text

An evaluation of human recombinant alpha interferon in patients with metastatic gastrinoma by Pisegna, J R, Slimak, G G, Doppman, J L, Strader, D B, Metz, D C, Benya, R V, Orbuch, M, Fishbeyn, V A, Fraker, D L, Norton, J A

“…Metastatic gastrinoma is becoming increasingly recognized in patients with Zollinger-Ellison Syndrome. The mean 5-year survival of these patients is < 20%…”
Get more information

The case for gastrin-releasing peptide acting as a morphogen when it and its receptor are aberrantly expressed in cancer by Jensen, Jo Annah G, Carroll, Robert E, Benya, Richard V

“…Gastrin-releasing peptide (GRP) and its receptor (GRP-R) are frequently expressed by cancers of the gastrointestinal tract, breast, lung, and prostate. Most…”
Get full text