Search Results - "Bentzen, Bo H."

Quantitative proteome comparison of human hearts with those of model organisms by Linscheid, Nora, Santos, Alberto, Poulsen, Pi Camilla, Mills, Robert W, Calloe, Kirstine, Leurs, Ulrike, Ye, Johan Z, Stolte, Christian, Thomsen, Morten B, Bentzen, Bo H, Lundegaard, Pia R, Olesen, Morten S, Jensen, Lars J, Olsen, Jesper V, Lundby, Alicia

“…Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from…”
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Contribution of Kv7 Channels to Basal Coronary Flow and Active Response to Ischemia by KHANAMIRI, Saereh, SOLTYSINSKA, Ewa, JEPPS, Thomas A, BENTZEN, Bo H, CHADHA, Preet S, SCHMITT, Nicole, GREENWOOD, Iain A, OLESEN, Søren-Peter

“…The goal of the present study was to determine the role of KCNQ-encoded Kv channels (Kv7 channels) in the passive and active regulation of coronary flow in…”
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2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels by Simó-Vicens, Rafel, Bomholtz, Sofia H, Sørensen, Ulrik S, Bentzen, Bo H

“…A variety of polycyclic pyridines have been proposed as inhibitors of the small conductance calcium-activated potassium (SK) channel. To this group belongs…”
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Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation by Olesen, Morten S, Bentzen, Bo H, Nielsen, Jonas B, Steffensen, Annette B, David, Jens-Peter, Jabbari, Javad, Jensen, Henrik K, Haunsø, Stig, Svendsen, Jesper H, Schmitt, Nicole

“…Atrial fibrillation (AF) is the most common arrhythmia. The potassium current IKs is essential for cardiac repolarization. Gain-of-function mutations in KV7.1,…”
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Deep sequencing of atrial fibrillation patients with mitral valve regurgitation shows no evidence of mosaicism but reveals novel rare germline variants by Gregers, Emilie, MD, Ahlberg, Gustav, MSc, Christensen, Thea, MSc, Jabbari, Javad, MSc, PhD, Larsen, Kirstine O., BSc, Herfelt, Cecilie B., MSc, Henningsen, Kristoffer M., MD, PhD, Andreasen, Laura, MD, Thiis, Jens J., MD, Lund, Jens, MD, Holme, Susanne, MD, Haunsø, Stig, MD, DMSc, Bentzen, Bo H., MSc, PhD, Schmitt, Nicole, MSc, PhD, Svendsen, Jesper H., MD, DMSc, FESC, Olesen, Morten S., MSc, PhD

“…Background Atrial fibrillation (AF) is the most common cardiac arrhythmia. Valvular heart disease is a strong predictor, yet the underlying molecular…”
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Inhibition of the KCa2 potassium channel in atrial fibrillation: a randomized phase 2 trial by Holst, Anders G., Tomcsányi, János, Vestbjerg, Birgitte, Grunnet, Morten, Sørensen, Ulrik S., Diness, Jonas G., Bentzen, Bo H., Edvardsson, Nils, Hohnloser, Stefan H., Bhatt, Deepak L., Dorian, Paul

“…Existing antiarrhythmic drugs to treat atrial fibrillation (AF) have incomplete efficacy, contraindications and adverse effects, including proarrhythmia…”
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Gating kinetics and pharmacological properties of small-conductance Ca2+-activated potassium channels by van Herck, Ilsbeth G.M., Seutin, Vincent, Bentzen, Bo H., Marrion, Neil V., Edwards, Andrew G.

“…Small-conductance (SK) calcium-activated potassium channels are a promising treatment target in atrial fibrillation. However, the functional properties that…”
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4‐Aminopyridine: a pan voltage‐gated potassium channel inhibitor that enhances Kv7.4 currents and inhibits noradrenaline‐mediated contraction of rat mesenteric small arteries by Khammy, Makhala M, Kim, Sukhan, Bentzen, Bo H, Lee, Soojung, Choi, Inyeong, Aalkjær, Christian, Jepps, Thomas A

“…Background and Purpose Kv7.4 and Kv7.5 channels are regulators of vascular tone. 4‐Aminopyridine (4‐AP) is considered a broad inhibitor of voltage‐gated…”
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Pharmacological inhibition of SK‐channels with AP14145 prevents atrial arrhythmogenic changes in a porcine model for obstructive respiratory events by Linz, Benedikt, Hesselkilde, Eva M., Skarsfeldt, Mark A., Hertel, Julie N., Sattler, Stefan M., Yan, Yannan, Tfelt‐Hansen, Jacob, Diness, Jonas G., Bentzen, Bo H., Linz, Dominik, Jespersen, Thomas

“…Background Obstructive sleep apnea (OSA) creates a complex substrate for atrial fibrillation (AF), which is refractory to many clinically available…”
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BK channel activators and their therapeutic perspectives by Bentzen, Bo H, Olesen, Søren-Peter, Rønn, Lars C B, Grunnet, Morten

“…The large conductance calcium- and voltage-activated K(+) channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate…”
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Polyunsaturated fatty acid‐derived IKs channel activators shorten the QT interval ex‐vivo and in‐vivo by Skarsfeldt, Mark A., Liin, Sara I., Larsson, Hans P., Bentzen, Bo H.

“…Aim We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex‐vivo and in‐vivo guinea pig hearts…”
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Polyunsaturated fatty acid-derived I Ks channel activators shorten the QT interval ex-vivo and in-vivo by Skarsfeldt, Mark A, Liin, Sara I, Larsson, Hans P, Bentzen, Bo H

“…We aimed to assess the ability of natural and modified polyunsaturated fatty acids (PUFAs) to shorten QT interval in ex-vivo and in-vivo guinea pig hearts. The…”
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Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy by Diness, Jonas G, Bentzen, Bo H, Sørensen, Ulrik S, Grunnet, Morten

“…Small-conductance Ca-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased…”
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A new negative allosteric modulator, AP14145, for the study of small conductance calcium‐activated potassium (KCa2) channels by Simó‐Vicens, Rafel, Kirchhoff, Jeppe E, Dolce, Bernardo, Abildgaard, Lea, Speerschneider, Tobias, Sørensen, Ulrik S, Grunnet, Morten, Diness, Jonas G, Bentzen, Bo H

“…Background and Purpose Small conductance calcium‐activated potassium (KCa2) channels represent a promising atrial‐selective target for treatment of atrial…”
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Effect of antiarrhythmic drugs on small conductance calcium – activated potassium channels by Simó-Vicens, Rafel, Sauter, Daniel R.P., Grunnet, Morten, Diness, Jonas G., Bentzen, Bo H.

“…Atrial fibrillation (AF) is the most common type of arrhythmia. Current pharmacological treatment for AF is moderately effective and/or increases the risk of…”
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The Tunicate Metabolite 2‑(3,5-Diiodo-4-methoxyphenyl)ethan-1-amine Targets Ion Channels of Vertebrate Sensory Neurons by Paguigan, Noemi D, Yan, Yannan, Karthikeyan, Manju, Chase, Kevin, Carter, Jackson, Leavitt, Lee S, Lim, Albebson L, Lin, Zhenjian, Memon, Tosifa, Christensen, Sean, Bentzen, Bo H, Schmitt, Nicole, Reilly, Christopher A, Teichert, Russell W, Raghuraman, Shrinivasan, Olivera, Baldomero M, Schmidt, Eric W

“…Marine tunicates produce defensive amino-acid-derived metabolites, including 2-(3,5-diiodo-4-methoxyphenyl)­ethan-1-amine (DIMTA), but their mechanisms of…”
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pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts by Skarsfeldt, Mark A., Jepps, Thomas A., Bomholtz, Sofia H., Abildgaard, Lea, Sørensen, Ulrik S., Gregers, Emilie, Svendsen, Jesper H., Diness, Jonas G., Grunnet, Morten, Schmitt, Nicole, Olesen, Søren-Peter, Bentzen, Bo H.

“…In isolated human atrial cardiomyocytes, inhibition of K 2P 3.1 K + channels results in action potential (action potential duration (APD)) prolongation. It has…”
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Biophysical characterization of inwardly rectifying potassium currents (I(K1) I(K,ACh), I(K,Ca)) using sinus rhythm or atrial fibrillation action potential waveforms by Tang, Chuyi, Skibsbye, Lasse, Yuan, Lei, Bentzen, Bo H, Jespersen, Thomas

“…Although several physiological, pathophysiological and regulatory properties of classical inward rectifier K+ current I(K1), G-protein coupled…”
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First Clinical Study with AP30663 - a K Ca 2 Channel Inhibitor in Development for Conversion of Atrial Fibrillation by Gal, Pim, Klaassen, Erica S, Bergmann, Kirsten R, Saghari, Mahdi, Burggraaf, Jacobus, Kemme, Michiel J B, Sylvest, Christina, Sørensen, Ulrik, Bentzen, Bo H, Grunnet, Morten, Diness, Jonas G, Edvardsson, Nils

“…Pharmacological cardioversion of atrial fibrillation (AF) is frequently inefficacious. AP30663, a small conductance Ca activated K (K 2) channel blocker,…”
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Pharmacological inhibition of IK1 by PA‐6 in isolated rat hearts affects ventricular repolarization and refractoriness by Skarsfeldt, Mark A., Carstensen, Helena, Skibsbye, Lasse, Tang, Chuyi, Buhl, Rikke, Bentzen, Bo H., Jespersen, Thomas

“…The inwardly rectifying potassium current (IK1) conducted through Kir2.X channels contribute to repolarization of the cardiac action potential and to…”
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