Search Results - "Benton, Christopher M"

Variability in the analysis of 25-hydroxyvitamin D by liquid chromatography–tandem mass spectrometry: The devil is in the detail by Couchman, Lewis, Benton, Christopher M., Moniz, Cajetan F.

“…Liquid chromatography–tandem mass spectrometry (LC–MS/MS) is increasingly used in clinical laboratories for the analysis of 25-hydroxyvitamin D (25OHD), but…”
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Ultra high-performance liquid chromatography of porphyrins by Benton, Christopher M., Lim, Chang Kee, Ritchie, Harald J., Moniz, Caje, Jones, Donald J.L.

“…ABSTRACT An ultra high‐performance liquid chromatographic (UHPLC) system was developed and optimized for the separation of porphyrins of clinical interest…”
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Early detection of metabolic changes in drug-induced steatosis using metabolomics approaches by Yong, Helena Y, Larrouy-Maumus, Gerald, Zloh, Mire, Smyth, Rosemary, Ataya, Rayan, Benton, Christopher M, Munday, Michael R

“…Steatosis is the accumulation of triglycerides in hepatic cells wherein fats exceed 5% of the entire liver weight. Although steatotic liver damage is…”
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Ultra‐fast LC–MS/MS in therapeutic drug monitoring: Quantification of clozapine and norclozapine in human plasma by Couchman, Lewis, Fisher, Danielle S., Subramaniam, Krithika, Handley, Simon A., Boughtflower, Robert J., Benton, Christopher M., Flanagan, Robert J.

“…A novel approach to high‐throughput, targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) analysis has been developed. A single chromatographic…”
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Changes in urinary metabolomic profile during relapsing renal vasculitis by Al-Ani, Bahjat, Fitzpatrick, Martin, Al-Nuaimi, Hamad, Coughlan, Alice M., Hickey, Fionnuala B., Pusey, Charles D., Savage, Caroline, Benton, Christopher M., O’Brien, Eóin C., O’Toole, Declan, Mok, Ken H., Young, Stephen P., Little, Mark A.

“…Current biomarkers of renal disease in systemic vasculitis lack predictive value and are insensitive to early damage. To identify novel biomarkers of renal…”
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Liquid chromatography and mass spectrometry of haem biosynthetic intermediates: a review by Benton, Christopher M., Lim, Chang Kee

“…ABSTRACT This article discusses the separation, analysis and characterisation of intermediates and oxidative by‐products of the haem biosynthetic pathway by…”
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Travelling wave ion mobility mass spectrometry of 5-aminolaevulinic acid, porphobilinogen and porphyrins by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Jones, Donald J. L.

“…RATIONALE Human porphyrias, diseases caused by enzyme defects in haem biosynthesis, are characterised by the excessive production, accumulation and excretion…”
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Direct and simultaneous quantitation of 5-aminolaevulinic acid and porphobilinogen in human serum or plasma by hydrophilic interaction liquid chromatography-atmospheric pressure chemical ionization/tandem mass spectrometry by Benton, Christopher M., Couchman, Lewis, Marsden, Joanne T., Rees, David C., Moniz, Caje, Lim, Chang Kee

“…ABSTRACT Serum/plasma concentrations of 5‐aminolaevulinic acid (ALA) and porphobilinogen (PBG) are elevated in patients with acute hepatic porphyrias,…”
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Separation and fragmentation study of isocoproporphyrin derivatives by UHPLC-ESI-exact mass MS/MS and identification of a new isocoproporphyrin sulfonic acid metabolite by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Baxter, Sinéad L., Jones, Donald J. L.

“…Isocoproporphyrin and its derivatives are commonly used as biomarkers of porphyria cutanea tarda, heavy metal toxicity and hexachlorobenzene (HCB) intoxication…”
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Porphyrinogen fragmentation profiles by ultra-high-performance liquid chromatography/electrospray ionisation tandem mass spectrometry by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Jones, Donald J. L.

“…An ultra‐high‐performance liquid chromatography/electrospray ionisation tandem mass spectrometry system is described for the separation and characterisation of…”
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Ultra high-performance liquid chromatography of porphyrins in clinical materials: column and mobile phase selection and optimisation by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Jones, Donald JL

“…ABSTRACT Ultra high‐performance liquid chromatographic (UHPLC) systems on columns packed with materials ranging from 1.9 to 2.7 µm average particle size were…”
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Direct and simultaneous determination of 5-aminolaevulinic acid and porphobilinogen in urine by hydrophilic interaction liquid chromatography-electrospray ionisation/tandem mass spectrometry by Benton, Christopher M., Couchman, Lewis, Marsden, Joanne T., Rees, David C., Moniz, Caje, Lim, Chang Kee

“…ABSTRACT Urinary concentrations of 5‐aminolaevulinic acid (ALA) and porphobilinogen (PBG) are elevated in patients with acute hepatic porphyrias, especially…”
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Liquid chromatography-tandem mass spectrometry of porphyrins and porphyrinogens in biological materials: separation and identification of interfering poly(ethylene) glycol by travelling wave ion mobility spectrometry/tandem mass spectrometry by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Jones, Donald J. L.

“…ABSTRACT Biological and clinical samples for porphyrin and porphyrinogen analyses by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) are often…”
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Separation and fragmentation study of isocoproporphyrin derivatives by UHPLC-ESI-exact mass MS/MS and identification of a new isocoproporphyrin sulfonic acid metabolite: UHPLC-MS/MS of isocoproporphyrin derivatives by Benton, Christopher M., Lim, Chang Kee, Moniz, Caje, Baxter, Sinéad L., Jones, Donald J. L.

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Changes in Plasma Phospholipids in the Presence and Absence of Erythrocytes: 31 P‐NMR Time‐Course Studies by Nourt‐Sorkhabi, M. Hossein, Sullivan, David R., Benton, Christopher M., Kuchel, Philip W.

“…Whole human blood and plasma were incubated at 37°C and 31 P‐NMR spectra were acquired from aliquots of plasma dissolved in sodium cholate. The narrow…”
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Changes in Plasma Phospholipids in the Presence and Absence of Erythrocytes by Nourt‐Sorkhabi, M. Hossein, Sullivan, David R., Benton, Christopher M., Kuchel, Philip W.

“…Whole human blood and plasma were incubated at 37°C and 31P‐NMR spectra were acquired from aliquots of plasma dissolved in sodium cholate. The narrow…”
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