Search Results - "Bentele, Kajetan"
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Efficient translation initiation dictates codon usage at gene start
Published in Molecular systems biology (18-06-2013)“…The genetic code is degenerate; thus, protein evolution does not uniquely determine the coding sequence. One of the puzzles in evolutionary genetics is…”
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Investigating APOE, APP-Aβ metabolism genes and Alzheimer’s disease GWAS hits in brain small vessel ischemic disease
Published in Scientific reports (28-04-2020)“…Alzheimer’s disease and small vessel ischemic disease frequently co-exist in the aging brain. However, pathogenic links between these 2 disorders are yet to be…”
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3
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure
Published in PLoS genetics (10-01-2018)“…Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. However, the impact of enhanced…”
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An exploratory investigation of brain collateral circulation plasticity after cerebral ischemia in two experimental C57BL/6 mouse models
Published in Journal of cerebral blood flow and metabolism (01-02-2020)“…Brain collateral circulation is an essential compensatory mechanism in response to acute brain ischemia. To study the temporal evolution of brain macro and…”
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5
Coupling phenotypic persistence to DNA damage increases genetic diversity in severe stress
Published in Nature ecology & evolution (04-01-2017)“…Mutation rate balances the need to protect genome integrity with the advantage of evolutionary innovations. Microorganisms increase their mutation rate when…”
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6
Exponential signaling gain at the receptor level enhances signal-to-noise ratio in bacterial chemotaxis
Published in PloS one (01-04-2014)“…Cellular signaling systems show astonishing precision in their response to external stimuli despite strong fluctuations in the molecular components that…”
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Role of translational coupling in robustness of bacterial chemotaxis pathway
Published in PLoS biology (18-08-2009)“…Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary…”
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Shared and oppositely regulated transcriptomic signatures in Huntington's disease and brain ischemia confirm known and unveil novel potential neuroprotective genes
Published in Neurobiology of aging (01-08-2021)“…•Huntington's disease and subcortical vascular dementia display similar dementing features, shaped by different degrees of striatal atrophy, deep white matter…”
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PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice
Published in Scientific reports (16-03-2021)“…Recently, several genome-wide association studies identified PHACTR1 as key locus for five diverse vascular disorders: coronary artery disease, migraine,…”
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10
Role of Translational Coupling in Robustness of Bacterial Chemotaxis Pathway: e1000171
Published in PLoS biology (01-08-2009)“…Chemotaxis allows bacteria to colonize their environment more efficiently and to find optimal growth conditions, and is consequently under strong evolutionary…”
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11
Abstract 15489: Adipose Tissue Lipolysis Modifies the Cardiac Lipidome in Chronic Heart Failure
Published in Circulation (New York, N.Y.) (11-11-2016)“…IntroductionAdipose tissue lipolysis often occurs during the development of heart failure as a consequence of chronic adrenergic stimulation and increased…”
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