Search Results - "Bensel, Nicolas"
-
1
Pd(II)-Catalyzed Cascade Wacker−Heck Reaction: Chemoselective Coupling of Two Electron-Deficient Reactants
Published in Journal of organic chemistry (27-10-2006)“…A novel palladium(II)-catalyzed oxy-carbopalladation process was developed allowing for the orchestrated union of hydroxy ynones with ethyl acrylate, two…”
Get full text
Journal Article -
2
A Structural Basis for the Activity of Retro-Diels-Alder Catalytic Antibodies: Evidence for a Catalytic Aromatic Residue
Published in Proceedings of the National Academy of Sciences - PNAS (23-07-2002)“…The nitroxyl synthase catalytic antibodies 10F11, 9D9, and 27C5 catalyze the release of nitroxyl from a bicyclic pro-drug by accelerating a retro-Diels-Alder…”
Get full text
Journal Article -
3
A Chemometric Approach to Map Reaction Media Chemoselectivity: Example of Selective Debenzylation
Published in European Journal of Organic Chemistry (01-04-2010)“…A chemometric process consisting in measuring the reactivity of a set of substrates under standardized and complementary reaction conditions was run to…”
Get full text
Book Review Journal Article -
4
A low background high-Throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone
Published in Bioorganic & medicinal chemistry letters (07-07-2003)“…Esters and acyloxymethyl ethers of umbelliferone were evaluated as fluorogenic substrates for lipases and esterases with respect to stability and resistance to…”
Get full text
Journal Article -
5
Sandwich Immunoassay as a High-Throughput Screening Method for Cross-Coupling Reactions
Published in Angewandte Chemie International Edition (28-10-2005)“…Catalyst sandwich: An efficient and sensitive high‐throughput‐screening method that uses sandwich immunoassays was developed and applied to the Sonogashira…”
Get full text
Journal Article -
6
Fluorogenic Cyanohydrin Esters as Chiral Probes for Esterase and Lipase Activity
Published in Advanced synthesis & catalysis (01-06-2003)“…Fluorogenic cyanohydrin esters were prepared that release the fluorescent product umbelliferone by secondary decomposition of the primary cyanohydrin reaction…”
Get full text
Journal Article -
7
Pivalase Catalytic Antibodies: Towards Abzymatic Activation of Prodrugs
Published in Chemistry : a European journal (05-11-2001)“…Screening of monoclonal‐antibody libraries generated against the tert‐butyl phosphonate hapten 2 and the chloromethyl phosphonate hapten 3 with…”
Get full text
Journal Article -
8
Mesyl guaiacol: a versatile intermediate for the synthesis of 5-aminomethyl guaiacol and related compounds
Published in Tetrahedron letters (03-06-2002)“…An original synthetic pathway for the preparation of 5-substituted guaiacol derivatives is described. This method relies on the deactivation of the phenol…”
Get full text
Journal Article -
9
New C(4)-Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution
Published in Helvetica chimica acta (01-09-2004)“…Electrophilic alkylation of colchicine at C(4) was accomplished by a multicomponent aromatic electrophilic substitution reaction with electrophilic aldehydes…”
Get full text
Journal Article -
10
Sandwich Immunoassay as a High-Throughput Screening Method for Cross-Coupling Reactions
Published in Angewandte Chemie (28-10-2005)“…Katalysator‐Sandwich: Ein effizientes und empfindliches Hochdurchsatz‐Screeningverfahren auf der Grundlage von Sandwich‐Immunassays wurde auf die…”
Get full text
Journal Article -
11
Straightforward synthesis of N-protected benzylic amines by carbamoalkylation of aromatic compounds
Published in Tetrahedron letters (29-01-1999)“…A wide range of alkoxycarbonyl protected benzylic amines have been synthesized in a three component reaction involving a carbamate an aldehyde and an aromatic…”
Get full text
Journal Article -
12
Atropisomeric Transition State Analogs
Published in European journal of organic chemistry (01-04-2000)“…Transition state mimicry is one of the most powerful concepts in enzyme inhibitor design and has led to the development of catalytic antibodies. Transition…”
Get full text
Journal Article -
13
Catalytic Antibodies by Fluorescence Screening
Published in Helvetica chimica acta (13-01-1999)“…A series of eleven immunizations against transition‐state analogs were carried out to improve the catalytic properties of Ab 9D9, a catalytic antibody that…”
Get full text
Journal Article -
14
Sandwich Immunoassay as a High‐Throughput Screening Method for Cross‐Coupling Reactions
Published in Angewandte Chemie (28-10-2005)Get full text
Journal Article