Search Results - "Benoukraf, Touati"

Correspondence on NanoVar’s performance outlined by Jiang T. et al. in “Long-read sequencing settings for efficient structural variation detection based on comprehensive evaluation” by Tham, Cheng Yong, Benoukraf, Touati

“…Abstract A recent paper by Jiang et al. in BMC Bioinformatics presented guidelines on long-read sequencing settings for structural variation (SV) calling, and…”
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ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function by Zhou, Qiling, Yu, Miao, Tirado-Magallanes, Roberto, Li, Bin, Kong, Lingshi, Guo, Mingrui, Tan, Zi Hui, Lee, Sanghoon, Chai, Li, Numata, Akihiko, Benoukraf, Touati, Fullwood, Melissa Jane, Osato, Motomi, Ren, Bing, Tenen, Daniel G.

“…CCCTC binding factor (CTCF) is an important factor in the maintenance of chromatin–chromatin interactions, yet the mechanism regulating its binding to…”
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A unique H3K4me2 profile marks tissue-specific gene regulation by Pekowska, Aleksandra, Benoukraf, Touati, Ferrier, Pierre, Spicuglia, Salvatore

“…Characterization of the epigenetic landscape fundamentally contributes toward deciphering the regulatory mechanisms that govern gene expression. However,…”
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NanoVar: accurate characterization of patients' genomic structural variants using low-depth nanopore sequencing by Tham, Cheng Yong, Tirado-Magallanes, Roberto, Goh, Yufen, Fullwood, Melissa J, Koh, Bryan T H, Wang, Wilson, Ng, Chin Hin, Chng, Wee Joo, Thiery, Alexandre, Tenen, Daniel G, Benoukraf, Touati

“…The recent advent of third-generation sequencing technologies brings promise for better characterization of genomic structural variants by virtue of having…”
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DNMT1-interacting RNAs block gene-specific DNA methylation by Di Ruscio, Annalisa, Ebralidze, Alexander K., Benoukraf, Touati, Amabile, Giovanni, Goff, Loyal A., Terragni, Jolyon, Figueroa, Maria Eugenia, De Figueiredo Pontes, Lorena Lobo, Alberich-Jorda, Meritxell, Zhang, Pu, Wu, Mengchu, D’Alò, Francesco, Melnick, Ari, Leone, Giuseppe, Ebralidze, Konstantin K., Pradhan, Sriharsa, Rinn, John L., Tenen, Daniel G.

“…DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data…”
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ColocZStats: a z-stack signal colocalization extension tool for 3D slicer by Chen, Xiang, Thakur, Teena, Jeyasekharan, Anand D, Benoukraf, Touati, Meruvia-Pastor, Oscar

“…Confocal microscopy has evolved to be a widely adopted imaging technique in molecular biology and is frequently utilized to achieve accurate subcellular…”
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Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia by Matsumura, Takayoshi, Nakamura-Ishizu, Ayako, Muddineni, Siva Sai Naga Anurag, Tan, Darren Qiancheng, Wang, Chelsia Qiuxia, Tokunaga, Kenji, Tirado-Magallanes, Roberto, Sian, Stephanie, Benoukraf, Touati, Okuda, Tsukasa, Asou, Norio, Matsuoka, Masao, Osato, Motomi, Suda, Toshio

“…RUNX1 is among the most frequently mutated genes in human leukemia, and the loss or dominant-negative suppression of RUNX1 function is found in myelodysplastic…”
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Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies by Saei, Azad, Palafox, Marta, Benoukraf, Touati, Kumari, Nishi, Jaynes, Patrick William, Iyengar, Prasanna Vasudevan, Muñoz-Couselo, Eva, Nuciforo, Paolo, Cortés, Javier, Nötzel, Christopher, Kumarakulasinghe, Nesaretnam Barr, Richard, John Lalith Charles, Bin Adam Isa, Zul Fazreen, Pang, Brendan, Guzman, Marta, Siqin, Zhou, Yang, Henry, Tam, Wai Leong, Serra, Violeta, Eichhorn, Pieter Johan Adam

“…RAF kinase inhibitors are clinically active in patients with BRAF (V600E) mutant melanoma. However, rarely do tumors regress completely, with the majority of…”
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Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance by Numata, Akihiko, Kwok, Hui Si, Zhou, Qi-Ling, Li, Jia, Tirado-Magallanes, Roberto, Angarica, Vladimir Espinosa, Hannah, Rebecca, Park, Jihye, Wang, Chelsia Qiuxia, Krishnan, Vaidehi, Rajagopalan, Deepa, Zhang, Yanzhou, Zhou, Siqin, Welner, Robert S., Osato, Motomi, Jha, Sudhakar, Bohlander, Stefan K., Göttgens, Berthold, Yang, Henry, Benoukraf, Touati, Lough, John W., Bararia, Deepak, Tenen, Daniel G.

“…Hematopoietic stem cells (HSCs) have the potential to replenish the blood system for the lifetime of the organism. Their 2 defining properties, self-renewal…”
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NicE-seq: high resolution open chromatin profiling by Ponnaluri, V K Chaithanya, Zhang, Guoqiang, Estève, Pierre-Olivier, Spracklin, George, Sian, Stephanie, Xu, Shuang-Yong, Benoukraf, Touati, Pradhan, Sriharsa

“…Open chromatin profiling integrates information across diverse regulatory elements to reveal the transcriptionally active genome. Tn5 transposase and DNase I…”
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Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene by Pater, Justin A., Penney, Cindy, O’Rielly, Darren D., Griffin, Anne, Kamal, Lara, Brownstein, Zippora, Vona, Barbara, Vinkler, Chana, Shohat, Mordechai, Barel, Ortal, French, Curtis R., Singh, Sushma, Werdyani, Salem, Burt, Taylor, Abdelfatah, Nelly, Houston, Jim, Doucette, Lance P., Squires, Jessica, Glaser, Fabian, Roslin, Nicole M., Vincent, Daniel, Marquis, Pascale, Woodland, Geoffrey, Benoukraf, Touati, Hawkey-Noble, Alexia, Avraham, Karen B., Stanton, Susan G., Young, Terry-Lynn

“…Sequencing exomes/genomes have been successful for identifying recessive genes; however, discovery of dominant genes including deafness genes (DFNA) remains…”
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Disruption of the C/EBPα—miR-182 balance impairs granulocytic differentiation by Wurm, Alexander Arthur, Zjablovskaja, Polina, Kardosova, Miroslava, Gerloff, Dennis, Bräuer-Hartmann, Daniela, Katzerke, Christiane, Hartmann, Jens-Uwe, Benoukraf, Touati, Fricke, Stephan, Hilger, Nadja, Müller, Anne-Marie, Bill, Marius, Schwind, Sebastian, Tenen, Daniel G., Niederwieser, Dietger, Alberich-Jorda, Meritxell, Behre, Gerhard

“…Transcription factor C/EBPα is a master regulator of myelopoiesis and its inactivation is associated with acute myeloid leukemia. Deregulation of C/EBPα by…”
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The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia by Numata, Akihiko, Kwok, Hui Si, Kawasaki, Akira, Li, Jia, Zhou, Qi-Ling, Kerry, Jon, Benoukraf, Touati, Bararia, Deepak, Li, Feng, Ballabio, Erica, Tapia, Marta, Deshpande, Aniruddha J., Welner, Robert S., Delwel, Ruud, Yang, Henry, Milne, Thomas A., Taneja, Reshma, Tenen, Daniel G.

“…Acute Myeloid Leukemia (AML) with MLL gene rearrangements demonstrate unique gene expression profiles driven by MLL-fusion proteins. Here, we identify the…”
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miREM: an expectation-maximization approach for prioritizing miRNAs associated with gene-set by Abdul Hadi, Luqman Hakim, Xuan Lin, Quy Xiao, Minh, Tri Tran, Loh, Marie, Ng, Hong Kiat, Salim, Agus, Soong, Richie, Benoukraf, Touati

“…The knowledge of miRNAs regulating the expression of sets of mRNAs has led to novel insights into numerous and diverse cellular mechanisms. While a single…”
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Correction to: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors by Zjablovskaja, Polina, Kardosova, Miroslava, Danek, Petr, Angelisova, Pavla, Benoukraf, Touati, Wurm, Alexander A., Kalina, Tomas, Sian, Stephanie, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tenen, Daniel G., Behre, Gerhard, Fiore, Fréderic, Malissen, Bernard, Horejsi, Vaclav, Alberich-Jorda, Meritxell

“…Since publication of this article, the authors identified an error in the acknowledgments section. The original sentence in acknowledgments reads as follows:…”
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H3K4 tri-methylation provides an epigenetic signature of active enhancers by Pekowska, Aleksandra, Benoukraf, Touati, Zacarias-Cabeza, Joaquin, Belhocine, Mohamed, Koch, Frederic, Holota, Hélène, Imbert, Jean, Andrau, Jean-Christophe, Ferrier, Pierre, Spicuglia, Salvatore

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Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression by Chong, Yong Chun, Toh, Tan Boon, Chan, Zhiling, Lin, Quy Xiao Xuan, Thng, Dexter Kai Hao, Hooi, Lissa, Ding, Zhaobing, Shuen, Timothy, Toh, Han Chong, Dan, Yock Young, Bonney, Glenn Kunnath, Zhou, Lei, Chow, Pierce, Wang, Yulan, Benoukraf, Touati, Chow, Edward Kai‐Hua, Han, Weiping

“…We demonstrate that in human HCCs with deregulated expression of purine metabolic enzymes, targeting purine metabolism was effective in blocking tumor cell…”
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PU.1-c-Jun interaction is crucial for PU.1 function in myeloid development by Zhao, Xinhui, Bartholdy, Boris, Yamamoto, Yukiya, Evans, Erica K., Alberich-Jordà, Meritxell, Staber, Philipp B., Benoukraf, Touati, Zhang, Pu, Zhang, Junyan, Trinh, Bon Q., Crispino, John D., Hoang, Trang, Bassal, Mahmoud A., Tenen, Daniel G.

“…The Ets transcription factor PU.1 is essential for inducing the differentiation of monocytes, macrophages, and B cells in fetal liver and adult bone marrow…”
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The gene signature in CCAAT-enhancer-binding protein α dysfunctional acute myeloid leukemia predicts responsiveness to histone deacetylase inhibitors by Liss, Adam, Ooi, Chia-Huey, Zjablovskaja, Polina, Benoukraf, Touati, Radomska, Hanna S, Ju, Chen, Wu, Mengchu, Balastik, Martin, Delwel, Ruud, Brdicka, Tomas, Tan, Patrick, Tenen, Daniel G, Alberich-Jorda, Meritxell

“…C/EPBα proteins, encoded by the CCAAT-enhancer-binding protein α gene, play a crucial role in granulocytic development, and defects in this transcription…”
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Characterisation of genome-wide PLZF/RARA target genes by Spicuglia, Salvatore, Vincent-Fabert, Christelle, Benoukraf, Touati, Tibéri, Guillaume, Saurin, Andrew J, Zacarias-Cabeza, Joaquin, Grimwade, David, Mills, Ken, Calmels, Boris, Bertucci, François, Sieweke, Michael, Ferrier, Pierre, Duprez, Estelle

“…The PLZF/RARA fusion protein generated by the t(11;17)(q23;q21) translocation in acute promyelocytic leukaemia (APL) is believed to act as an oncogenic…”
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