Search Results - "Benoit, Yannick D."

Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells by Nakanishi, Mio, Mitchell, Ryan R., Benoit, Yannick D., Orlando, Luca, Reid, Jennifer C., Shimada, Kenichi, Davidson, Kathryn C., Shapovalova, Zoya, Collins, Tony J., Nagy, Andras, Bhatia, Mickie

“…The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of…”
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Emerging role of G9a in cancer stemness and promises as a therapeutic target by Haebe, Joshua R., Bergin, Christopher J., Sandouka, Tamara, Benoit, Yannick D.

“…The histone methyltransferase G9a is well-documented for its implication in neoplastic growth. However, recent investigations have demonstrated a key…”
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Protocol for serial organoid formation assay using primary colorectal cancer tissues to evaluate cancer stem cell activity by Bergin, Christopher J., Benoit, Yannick D.

“…Organoids can enable the study of solid tumors initiated from a single cancer stem cell (CSC) ex vivo. We describe a serial tumor organoid plating protocol…”
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Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states by Lee, Jong-Hee, Lee, Jung Bok, Shapovalova, Zoya, Fiebig-Comyn, Aline, Mitchell, Ryan R., Laronde, Sarah, Szabo, Eva, Benoit, Yannick D., Bhatia, Mickie

“…Human-induced pluripotent stem cells (hiPSCs) provide an invaluable source for regenerative medicine, but are limited by proficient lineage-specific…”
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Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency by Lee, Jong-Hee, Laronde, Sarah, Collins, Tony J., Shapovalova, Zoya, Tanasijevic, Borko, McNicol, Jamie D., Fiebig-Comyn, Aline, Benoit, Yannick D., Lee, Jung Bok, Mitchell, Ryan R., Bhatia, Mickie

“…Human pluripotent stem cells (hPSCs) have been reported in naive and primed states. However, the ability to generate mature cell types remains the imperative…”
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Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene by Laursen, Kristian B, Mongan, Nigel P, Zhuang, Yong, Ng, Mary M, Benoit, Yannick D, Gudas, Lorraine J

“…Polycomb proteins play key roles in mediating epigenetic modifications that occur during cell differentiation. The Polycomb repressive complex 2 (PRC2)…”
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Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells by Benoit, Yannick D., Witherspoon, Mavee S., Laursen, Kristian B., Guezguez, Amel, Beauséjour, Marco, Beaulieu, Jean-Francois, Lipkin, Steven M., Gudas, Lorraine J.

“…Colorectal cancer is among the leading causes of cancer death in the USA. The polycomb repressive complex 2 (PRC2), including core components SUZ12 and EZH2,…”
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Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells by Benoit, Yannick D., Laursen, Kristian B., Witherspoon, Mavee S., Lipkin, Steven M., Gudas, Lorraine J.

“…Colorectal cancer is ranked among the top leading causes of cancer death in industrialized populations. Polycomb group proteins, including Suz12 and Ezh2, are…”
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Integrin-linked kinase regulates migration and proliferation of human intestinal cells under a fibronectin-dependent mechanism by Gagné, David, Groulx, Jean-François, Benoit, Yannick D., Basora, Nuria, Herring, Elizabeth, Vachon, Pierre H., Beaulieu, Jean-François

“…Integrin‐linked kinase (ILK) plays a role in integrin signaling‐mediated extracellular matrix (ECM)–cell interactions and also acts as a scaffold protein in…”
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Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism by Benoit, Yannick D., Lussier, Carine, Ducharme, Pierre-Alexandre, Sivret, Sophie, Schnapp, Lynn M., Basora, Nuria, Beaulieu, Jean-François

“…Background. Integrins are transmembrane αβ heterodimer receptors that function as structural and functional bridges between the cytoskeleton and ECM…”
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Autophagy is active in normal colon mucosa by Groulx, Jean-Francois, Khalfaoui, Taoufik, Benoit, Yannick D, Bernatchez, Gérald, Carrier, Julie C, Basora, Nuria, Beaulieu, Jean-François

“…Recently, autophagy has been found to be strongly activated in colon cancer cells, but few studies have addressed the normal colon mucosa. The aim of this…”
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ILK supports RhoA/ROCK-mediated contractility of human intestinal epithelial crypt cells by inducing the fibrillogenesis of endogenous soluble fibronectin during the spreading process by Gagné, David, Benoit, Yannick D, Groulx, Jean-François, Vachon, Pierre H, Beaulieu, Jean-François

“…Fibronectin (FN) assembly into an insoluble fibrillar matrix is a crucial step in many cell responses to extracellular matrix (ECM) properties, especially with…”
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Pharmacological targeting of Sam68 functions in colorectal cancer stem cells by Masibag, Angelique N., Bergin, Christopher J., Haebe, Joshua R., Zouggar, Aïcha, Shah, Muhammad S., Sandouka, Tamara, Mendes da Silva, Amanda, Desrochers, François M., Fournier-Morin, Aube, Benoit, Yannick D.

“…Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC…”
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Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients by Aslostovar, Lili, Boyd, Allison L, Benoit, Yannick D, Di Lu, Justin, Garcia Rodriguez, Juan Luis, Nakanishi, Mio, Porras, Deanna P, Reid, Jennifer C, Mitchell, Ryan R, Leber, Brian, Xenocostas, Anargyros, Foley, Ronan, Bhatia, Mickie

“…The aberrant expression of dopamine receptors (DRDs) in acute myeloid leukemia (AML) cells has encouraged the repurposing of DRD antagonists such as…”
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Sam68 is a druggable vulnerability point in cancer stem cells by da Silva, Amanda Mendes, Yevdokimova, Veronika, Benoit, Yannick D.

“…Sam68 (Src associated in mitosis of 68 kDa) is an RNA-binding and multifunctional protein extensively characterized in numerous cellular functions, such as RNA…”
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Identification of Novel Molecules Targeting Cancer Stem Cells by Benoit, Yannick D

“…Multiple studies focused on tumor heterogeneity and cellular hierarchies have demonstrated the role of cancer stem cells (CSC) in tumor initiation and…”
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Vitamin A Deficiency Causes Hyperglycemia and Loss of Pancreatic β-Cell Mass by Trasino, Steven E., Benoit, Yannick D., Gudas, Lorraine J.

“…We show that vitamin A (all-trans-retinol) (VA) is required both for the maintenance of pancreatic β-cell and α-cell mass and for glucose-stimulated insulin…”
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Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche by Boyd, Allison L., Reid, Jennifer C., Salci, Kyle R., Aslostovar, Lili, Benoit, Yannick D., Shapovalova, Zoya, Nakanishi, Mio, Porras, Deanna P., Almakadi, Mohammed, Campbell, Clinton J. V., Jackson, Michael F., Ross, Catherine A., Foley, Ronan, Leber, Brian, Allan, David S., Sabloff, Mitchell, Xenocostas, Anargyros, Collins, Tony J., Bhatia, Mickie

“…Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal…”
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Molecular pathways: epigenetic modulation of Wnt-glycogen synthase kinase-3 signaling to target human cancer stem cells by Benoit, Yannick D, Guezguez, Borhane, Boyd, Allison L, Bhatia, Mickie

“…Aberrant regulation of the canonical Wnt signaling pathway (Wnt-β-catenin-GSK3 axis) has been a prevalent theme in cancer biology since earlier observations…”
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Colorectal Cancer Is Borrowing Blueprints from Intestinal Ontogenesis by Billingsley, Jacob L, Yevdokimova, Veronika, Ayoub, Kristina, Benoit, Yannick D

“…Colorectal tumors are heterogenous cellular systems harboring small populations of self-renewing and highly tumorigenic cancer stem cells (CSCs). Understanding…”
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