Search Results - "Bennoun, Myriam"

Lack of Hepcidin Gene Expression and Severe Tissue Iron Overload in Upstream Stimulatory Factor 2 (USF2) Knockout Mice by Nicolas, G, Bennoun, M, Devaux, I, Beaumont, C, Grandchamp, B, Kahn, A, Vaulont, S

“…We previously reported the disruption of the murine gene encoding the transcription factor USF2 and its consequences on glucose-dependent gene regulation in…”
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Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis by Lesbordes-Brion, Jeanne-Claire, Viatte, Lydie, Bennoun, Myriam, Lou, Dan-Qing, Ramey, Guillemette, Houbron, Christophe, Hamard, Ghislaine, Kahn, Axel, Vaulont, Sophie

“…We previously reported that mice made deficient for the transcriptional factor USF2 fail to express hepcidin 1 and hepcidin 2 genes as a consequence of…”
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Severe Iron Deficiency Anemia in Transgenic Mice Expressing Liver Hepcidin by Nicolas, Gaël, Bennoun, Myriam, Porteu, Arlette, Mativet, Sandrine, Beaumont, Carole, Grandchamp, Bernard, Sirito, Mario, Sawadogo, Michéle, Kahn, Axel, Vaulont, Sophie

“…We recently reported the hemochromatosis-like phenotype observed in our Usf2 knockout mice. In these mice, as in murine models of hemochromatosis and patients…”
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The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity by Viollet, Benoit, Andreelli, Fabrizio, Jørgensen, Sebastian B., Perrin, Christophe, Geloen, Alain, Flamez, Daisy, Mu, James, Lenzner, Claudia, Baud, Olivier, Bennoun, Myriam, Gomas, Emmanuel, Nicolas, Gaël, Wojtaszewski, Jørgen F.P., Kahn, Axel, Carling, David, Schuit, Frans C., Birnbaum, Morris J., Richter, Erik A., Burcelin, Rémy, Vaulont, Sophie

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Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice by Viatte, Lydie, Lesbordes-Brion, Jeanne-Claire, Lou, Dan-Qing, Bennoun, Myriam, Nicolas, Gaël, Kahn, Axel, Canonne-Hergaux, François, Vaulont, Sophie

“…Evidence is accumulating that hepcidin, a liver regulatory peptide, could be the common pathogenetic denominator of all forms of iron overload syndromes…”
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The amino-terminal region of SV40 large T antigen is sufficient to induce hepatic tumours in mice by BENNOUN, M, GRIMBER, G, COUTON, D, SEYE, A, MOLINA, T, BRIAND, P, JOULIN, V

“…The transforming activity of SV40 large T-antigen (Tag) depends on its binding to cellular proteins involved in the control of the cell cycle (p53, pRb,…”
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Hepcidin, A New Iron Regulatory Peptide by Nicolas, Gaël, Viatte, Lydie, Bennoun, Myriam, Beaumont, Carole, Kahn, Axel, Vaulont, Sophie

“…ABSTRACT Maintaining normal iron homeostasis is essential for the organism, as both iron deficiency and iron excess are associated with cellular dysfunction…”
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Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis by Vaulont, Sophie, Kahn, Axel, Beaumont, Carole, Nicolas, Gaël, Lou, Dan-Qing, Bennoun, Myriam, Andrews, Nancy C, Viatte, Lydie

“…Hereditary hemochromatosis is a prevalent genetic disorder of iron hyperabsorption leading to hyperferremia, tissue iron deposition and complications including…”
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Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice by Viatte, Lydie, Nicolas, Gaël, Lou, Dan-Qing, Bennoun, Myriam, Lesbordes-Brion, Jeanne-Claire, Canonne-Hergaux, François, Schönig, Kai, Bujard, Hermann, Kahn, Axel, Andrews, Nancy C., Vaulont, Sophie

“…We report the generation of a tetracycline-regulated (Tet ON) transgenic mouse model for acute and chronic expression of the iron regulatory peptide hepcidin…”
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Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by kupffer cells in vivo by LOU, Dan-Qing, LESBORDES, Jeanne-Claire, NICOLAS, Gaël, VIATTE, Lydie, BENNOUN, Myriam, VAN ROOIJEN, Nico, KAHN, Axel, RENIA, Laurent, VAULONT, Sophie

“…Hepcidin, a recently discovered iron regulatory peptide, is believed to inhibit the release of iron from absorptive enterocytes and macrophages. Liver hepcidin…”
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Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin iii sv40 t large antigen transgenic mice by de Coupade, Catherine, Gillet, Raphaëlle, Bennoun, Myriam, Briand, Pascale, Russo‐Marie, Françoise, Solito, Egle

“…We have used a transgenic animal model, which constitutively develops hepatocarcinoma (Antithrombin III SV40 T large Antigen: ASV), to study the involvement of…”
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Conditional hepatocarcinogenesis in mice expressing SV 40 early sequences by Lou, Dan-Qing, Molina, Thierry, Bennoun, Myriam, Porteu, Arlette, Briand, Pascale, Joulin, Virginie, Vasseur-Cognet, Mireille, Cavard, Catherine

“…We closely mimicked the in vivo setting in which sporadic hepatocarcinoma occurs by establishing a transgenic mouse model carrying regulatable SV40 early…”
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Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Commentary by CAMASCHELLA, Clara, VIATTE, Lydie, ANDREWS, Nancy C, VAULONT, Sophie, NICOLAS, Gaël, LOU, Dan-Qing, BENNOUN, Myriam, LESBORDES-BRION, Jeanne-Claire, CANONNE-HERGAUX, Francois, SCHONIG, Kai, BUJARD, Hermann, KAHN, Axel

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Effect of Bcl-2 expression on hepatic preneoplasia in mice by Gillet, Raphaëlle, Grimber, Gisèle, Cavard, Catherine, Bennoun, Myriam, Mignon, Alexandre, Briand, Pascale, Joulin, Virginie

“…In a transgenic model of hepatocellular carcinoma induced by the expression of SV40 early sequences (TAg mice), deregulation of hepatocyte proliferation…”
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The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity by Viollet, Benoit, Andreelli, Fabrizio, Jørgensen, Sebastian B., Perrin, Christophe, Geloen, Alain, Flamez, Daisy, Mu, James, Lenzner, Claudia, Baud, Olivier, Bennoun, Myriam, Gomas, Emmanuel, Nicolas, Gaël, Wojtaszewski, Jørgen F.P., Kahn, Axel, Carling, David, Schuit, Frans C., Birnbaum, Morris J., Richter, Erik A., Burcelin, Rémy, Vaulont, Sophie

“…AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To better understand the physiological role of AMPK, we…”
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The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity by Viollet, Benoit, Andreelli, Fabrizio, Jørgensen, Sebastian B, Perrin, Christophe, Geloen, Alain, Flamez, Daisy, Mu, James, Lenzner, Claudia, Baud, Olivier, Bennoun, Myriam, Gomas, Emmanuel, Nicolas, Gaël, Wojtaszewski, Jørgen F P, Kahn, Axel, Carling, David, Schuit, Frans C, Birnbaum, Morris J, Richter, Erik A, Burcelin, Rémy, Vaulont, Sophie

“…AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To better understand the physiological role of AMPK, we…”
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Fas-dependent apoptosis is impaired by SV40 T-antigen in transgenic liver by Rouquet, N, Allemand, I, Molina, T, Bennoun, M, Briand, P, Joulin, V

“…A transgenic mouse model for hepatocarcinoma has been previously produced by targeting SV40 T-antigen expression to the liver. To evaluate the perturbation of…”
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Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice by Dubois, N, Bennoun, M, Allemand, I, Molina, T, Grimber, G, Daudet-Monsac, M, Abelanet, R, Briand, P

“…A precise targeting of the SV40 T early region expression in the liver of transgenic mice was obtained using 700 bp of the antithrombin III regulatory…”
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Oval cell proliferation in early stages of hepatocarcinogenesis in simian virus 40 large T transgenic mice by Bennoun, M, Rissel, M, Engelhardt, N, Guillouzo, A, Briand, P, Weber-Benarous, A

“…In transgenic mice bearing the Simian Virus 40 large T antigen under the control of the human antithrombin III regulatory sequences, a stepwise progression…”
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Compensatory apoptosis in response to SV40 large T antigen expression in the liver by Allemand, I, Grimber, G, Kornprobst, M, Bennoun, M, Molina, T, Briand, P, Joulin, V

“…Transgenesis allows the in vivo determination of the effects of oncogene expression in normal tissues. In an attempt to understand the mechanism underlying…”
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