Search Results - "Benning, Rajdeep"

Pharmacokinetics and metabolism of [14C]anagliptin, a novel dipeptidyl peptidase-4 inhibitor, in humans by Furuta, Shinji, Smart, Clair, Hackett, Andrew, Benning, Rajdeep, Warrington, Steve

“…1. The disposition of anagliptin, an orally active, highly selective dipeptidyl peptidase-4 inhibitor, was investigated after a single oral dose of 100 mg/1.92…”
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Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models by Squires, Matthew, Ward, George, Saxty, Gordan, Berdini, Valerio, Cleasby, Anne, King, Peter, Angibaud, Patrick, Perera, Tim, Fazal, Lynsey, Ross, Douglas, Jones, Charlotte Griffiths, Madin, Andrew, Benning, Rajdeep K, Vickerstaffe, Emma, O'Brien, Alistair, Frederickson, Martyn, Reader, Michael, Hamlett, Christopher, Batey, Michael A, Rich, Sharna, Carr, Maria, Miller, Darcey, Feltell, Ruth, Thiru, Abarna, Bethell, Susanne, Devine, Lindsay A, Graham, Brent L, Pike, Andrew, Cosme, Jose, Lewis, Edward J, Freyne, Eddy, Lyons, John, Irving, Julie, Murray, Christopher, Newell, David R, Thompson, Neil T

“…We describe here the identification and characterization of 2 novel inhibitors of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine…”
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Regioselective Beckmann rearrangements of furanoside and pyranoside-derived oximes by Benning, Rajdeep K., Osborn, Helen M.I., Turkson, Andrea

“…The utility of the Beckmann rearrangement for the synthesis of glycoside-derived lactams, from oxime precursors, is described. The rearrangement is…”
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Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors by Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J, Feltell, Ruth, Giraldes, John, Hiscock, Steven D, Kim, Sunkyu, Kovats, Steven, Lagu, Bharat, Lewry, Kim, Loo, Alice, Lu, Yipin, Luzzio, Michael, Maniara, Wiesia, McMenamin, Rachel, Mortenson, Paul N, Benning, Rajdeep, O'Reilly, Marc, Rees, David C, Shen, Junqing, Smith, Troy, Wang, Yaping, Williams, Glyn, Woolford, Alison J.-A, Wrona, Wojciech, Xu, Mei, Yang, Fan, Howard, Steven

“…Herein, we describe the discovery of potent and highly selective inhibitors of both CDK4 and CDK6 via structure-guided optimization of a fragment-based…”
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