Search Results - "Bennin, David"

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK) by Chan, Keefe T., Bennin, David A., Huttenlocher, Anna

“…The coordinated and dynamic regulation of adhesions is required for cell migration. We demonstrated previously that limited proteolysis of talin1 by the…”
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Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage by Houseright, Ruth A, Miskolci, Veronika, Mulvaney, Oscar, Bortnov, Valeriu, Mosher, Deane F, Rindy, Julie, Bennin, David A, Huttenlocher, Anna

“…Neutrophil recruitment to tissue damage is essential for host defense but can also impede tissue repair. The cues that differentially regulate neutrophil…”
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Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration by Hsu, Alan Y., Wang, Decheng, Liu, Sheng, Lu, Justice, Syahirah, Ramizah, Bennin, David A., Huttenlocher, Anna, Umulis, David M., Wan, Jun, Deng, Qing

“…Neutrophil migration is essential for inflammatory responses to kill pathogens; however, excessive neutrophilic inflammation also leads to tissue injury and…”
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Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish by Deng, Qing, Sarris, Milka, Bennin, David A., Green, Julie M., Herbomel, Philippe, Huttenlocher, Anna

“…Direct visualization and characterization of Cxcr2 signaling as a mediator of systemic neutrophil reaction to a local infection. Neutrophils are the first line…”
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Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration by Cortesio, Christa L., Boateng, Lindsy R., Piazza, Timothy M., Bennin, David A., Huttenlocher, Anna

“…The dynamic turnover of integrin-mediated adhesions is important for cell migration. Paxillin is an adaptor protein that localizes to focal adhesions and has…”
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The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages by Starnes, Taylor W., Bennin, David A., Bing, Xinyu, Eickhoff, Jens C., Grahf, Daniel C., Bellak, Jason M., Seroogy, Christine M., Ferguson, Polly J., Huttenlocher, Anna

“…PSTPIP1 is a cytoskeletal adaptor and F-BAR protein that has been implicated in autoinflammatory disease, most notably in the PAPA syndrome: pyogenic sterile…”
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PTP1B phosphatase dampens iPSC-derived neutrophil motility and antimicrobial function by Giese, Morgan A, Bennin, David A, Schoen, Taylor J, Peterson, Ashley N, Schrope, Jonathan H, Brand, Josh, Jung, Ho Sun, Keller, Nancy P, Beebe, David J, Dinh, Huy Q, Slukvin, Igor I, Huttenlocher, Anna

“…Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Therapeutic use of primary neutrophils has been limited, as…”
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Citrullination of fibronectin modulates synovial fibroblast behavior by Shelef, Miriam A, Bennin, David A, Mosher, Deane F, Huttenlocher, Anna

“…Rheumatoid arthritis is an autoimmune arthritis characterized by joint destruction. Anti-citrullinated protein antibodies are pathologic in rheumatoid…”
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Effective and Rapid Generation of Functional Neutrophils from Induced Pluripotent Stem Cells Using ETV2-Modified mRNA by Brok-Volchanskaya, Vera S., Bennin, David A., Suknuntha, Kran, Klemm, Lucas C., Huttenlocher, Anna, Slukvin, Igor

“…Human induced pluripotent stem cells (hiPSCs) can serve as a versatile and scalable source of neutrophils for biomedical research and transfusion therapies…”
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Calpain-mediated proteolysis of talin regulates adhesion dynamics by Huttenlocher, Anna, Franco, Santos J, Rodgers, Mary A, Perrin, Benjamin J, Han, Jaewon, Bennin, David A, Critchley, David R

“…Dynamic regulation of adhesion complexes is required for cell migration and has therefore emerged as a key issue in the study of cell motility. Recent progress…”
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Citrullination regulates wound responses and tissue regeneration in zebrafish by Golenberg, Netta, Squirrell, Jayne M, Bennin, David A, Rindy, Julie, Pistono, Paige E, Eliceiri, Kevin W, Shelef, Miriam A, Kang, Junsu, Huttenlocher, Anna

“…Calcium is an important early signal in wound healing, yet how these early signals promote regeneration remains unclear. Peptidylarginine deiminases (PADs), a…”
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Integrin associated proteins differentially regulate neutrophil polarity and directed migration in 2D and 3D by Yamahashi, Yukie, Cavnar, Peter J., Hind, Laurel E., Berthier, Erwin, Bennin, David A., Beebe, David, Huttenlocher, Anna

“…Directed neutrophil migration in blood vessels and tissues is critical for proper immune function; however, the mechanisms that regulate three-dimensional…”
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Contact-dependent T cell activation and T cell stopping require talin1 by Wernimont, Sarah A, Wiemer, Andrew J, Bennin, David A, Monkley, Susan J, Ludwig, Thomas, Critchley, David R, Huttenlocher, Anna

“…T cell-APC contact initiates T cell activation and is maintained by the integrin LFA-1. Talin1, an LFA-1 regulator, localizes to the immune synapse (IS) with…”
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Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation by Korte, Benjamin G, Giese, Morgan A, Ramakrishnan, Gayathri, Ma, Stella, Bennin, David, Rindy, Julie, Dewey, Colin N, Huttenlocher, Anna

“…Neutrophils in the tumor microenvironment exhibit altered functions. However, the changes in neutrophil behavior during tumor initiation remain unclear. Here…”
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Focal adhesion kinase is required for synovial fibroblast invasion, but not murine inflammatory arthritis by Shelef, Miriam A, Bennin, David A, Yasmin, Nihad, Warner, Thomas F, Ludwig, Thomas, Beggs, Hilary E, Huttenlocher, Anna

“…Synovial fibroblasts invade cartilage and bone, leading to joint destruction in rheumatoid arthritis. However, the mechanisms that regulate synovial fibroblast…”
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Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation by Cortesio, Christa L, Perrin, Benjamin J, Bennin, David A, Huttenlocher, Anna

“…Growth factor stimulation induces the formation of dynamic actin structures known as dorsal ruffles. Mammalian actin-binding protein-1 (mAbp1) is an…”
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The PCH family member proline-serine-threonine phosphatase-interacting protein 1 targets to the leukocyte uropod and regulates directed cell migration by Cooper, Kate M, Bennin, David A, Huttenlocher, Anna

“…Pombe Cdc15 homology (PCH) family members have emerged as important regulators of membrane-cytoskeletal interactions. Here we show that PSTPIP1, a PCH family…”
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The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation by Wiemer, Andrew J., Wernimont, Sarah A., Cung, Thai-duong, Bennin, David A., Beggs, Hilary E., Huttenlocher, Anna

“…The focal adhesion kinase inhibitor, PF-562,271, is currently in clinical development for cancer, however it is not known how PF-562,271 affects T cell…”
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Generation of Human Neutrophils from Induced Pluripotent Stem Cells in Chemically Defined Conditions Using ETV2 Modified mRNA by Majumder, Aditi, Suknuntha, Kran, Bennin, David, Klemm, Lucas, Brok-Volchanskaya, Vera S., Huttenlocher, Anna, Slukvin, Igor

“…This protocol describes a rapid and efficient feeder-, serum-, and xeno-free method for neutrophil generation from hiPSCs using ETV2 modified mRNA (mmRNA),…”
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The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish by Dodd, M Ernest, Hatzold, Julia, Mathias, Jonathan R, Walters, Kevin B, Bennin, David A, Rhodes, Jennifer, Kanki, John P, Look, A Thomas, Hammerschmidt, Matthias, Huttenlocher, Anna

“…Epidermal hyperproliferation and inflammation are hallmarks of the human condition psoriasis. Here, we report that a zebrafish line with a mutation in the…”
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