Search Results - "Bennicelli, J L"

PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma by BENNICELLI, J. L, ADVANI, S, SCHÄFER, B. W, BARR, F. G

“…The t(2;13) and t(1;13) translocations of alveolar rhabdomyosarcoma (ARMS) result in chimeric PAX3-FKHR or PAX7-FKHR transcription factors, respectively. In…”
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Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma by GINSBERG, J. P, DAVIS, R. J, BENNICELLI, J. L, NAUTA, L. E, BARR, F. G

“…The 2;13 chromosomal translocation in alveolar rhabdomyosarcoma generates the chimeric protein PAX3-FKHR, which is a powerful transcriptional activator. We…”
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Mechanism For Transcriptional Gain of Function Resulting from Chromosomal Translocation in Alveolar Rhabdomyosarcoma by Bennicelli, Jeannette L., Edwards, Robin H., Barr, Frederic G.

“…The t(2;13) translocation of alveolar rhabdomyosarcoma results in tumor-specific expression of a chimeric transcription factor containing the N-terminal…”
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Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines by BARR, F. G, FITZGERALD, J. C, GINSBERG, J. P, VANELLA, M. L, DAVIS, R. J, BENNICELLI, J. L

“…PAX3 and PAX7 are closely related paired box family members expressed during early neural and myogenic development. Assay of PAX3 and PAX7 mRNA expression in…”
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Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma by Davis, R J, Bennicelli, J L, Macina, R A, Nycum, L M, Biegel, J A, Barr, F G

“…The FKHR gene, which contains a forkhead DNA-binding motif, is fused to either PAX3 or PAX7 by the t(2;13) or t(1;13) translocation in alveolar…”
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Characterization of tenascin secreted by human melanoma cells by HERLYN, M, GRAEVEN, U, SPEICHER, D, SELA, B.-A, BENNICELLI, J. L, KATH, R, GUERRY, D. IV

“…Tenascin is a large glycoprotein of the extracellular matrix. It shows a site-restricted expression during embryogenesis and can be found in adult tissues…”
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Production of interleukin 1 activity by cultured human melanoma cells by BENNICELLI, J. L, ELIAS, J, KERN, J, GUERRY, D. P. IV

“…A panel of melanoma cell lines derived from 7 primary and 20 metastatic lesions was tested for the production of interleukin 1 (IL-1) in standard mouse…”
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Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial by Bennett, Jean, Prof, Wellman, Jennifer, MSc, Marshall, Kathleen A, COT, McCague, Sarah, BA, Ashtari, Manzar, PhD, DiStefano-Pappas, Julie, BA, Elci, Okan U, PhD, Chung, Daniel C, DO, Sun, Junwei, MSc, Wright, J Fraser, PhD, Cross, Dominique R, MPH, Aravand, Puya, BA, Cyckowski, Laura L, BA, Bennicelli, Jeannette L, PhD, Mingozzi, Federico, PhD, Auricchio, Alberto, MD, Pierce, Eric A, MD, Ruggiero, Jason, MD, Leroy, Bart P, Prof, Simonelli, Francesca, Prof, High, Katherine A, MD, Maguire, Albert M, Prof

“…Summary Background Safety and efficacy have been shown in a phase 1 dose-escalation study involving a unilateral subretinal injection of a recombinant…”
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AAV2 gene therapy readministration in three adults with congenital blindness by Bennett, Jean, Ashtari, Manzar, Wellman, Jennifer, Marshall, Kathleen A, Cyckowski, Laura L, Chung, Daniel C, McCague, Sarah, Pierce, Eric A, Chen, Yifeng, Bennicelli, Jeannette L, Zhu, Xiaosong, Ying, Gui-Shuang, Sun, Junwei, Wright, J Fraser, Auricchio, Alberto, Simonelli, Francesca, Shindler, Kenneth S, Mingozzi, Federico, High, Katherine A, Maguire, Albert M

“…Demonstration of safe and stable reversal of blindness after a single unilateral subretinal injection of a recombinant adeno-associated virus (AAV) carrying…”
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Human melanoma cells transcribe interleukin 1 genes identical to those of monocytes by SHABON, U, BENNICELLI, J. L, DUPONT GUERRY, KOPROWSKI, H, RICCIARDI, R. P

“…Two molecular species of the pleotropic cytokine interleukin 1 (IL-1) are produced as products of two distinct genes transcribed by cells of the…”
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Wild type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains by Bennicelli, J L, Fredericks, W J, Wilson, R B, Rauscher, 3rd, F J, Barr, F G

“…Alveolar rhabdomyosarcoma (ARMS) is characterized cytogenetically by a t(2;13)(q35;q14) chromosomal translocation involving two transcription factor genes:…”
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Characteristics of cultured human melanocytes isolated from different stages of tumor progression by Herlyn, M, Thurin, J, Balaban, G, Bennicelli, J L, Herlyn, D, Elder, D E, Bondi, E, Guerry, D, Nowell, P, Clark, W H

“…Normal melanocytes and melanocytes of normal nevi, primary melanoma in the radial (RGP) and vertical (VGP) growth phases, and metastatic melanoma exhibited and…”
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Genetics and the biologic basis of sarcomas by Bennicelli, Jeannette L, Barr, Frederic G

“…Identification of genetic alterations has contributed greatly to the understanding of sarcoma biology. Additionally, detection of these abnormalities is…”
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Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression by Tomescu, Oana, Xia, Shujuan J, Strezlecki, Donna, Bennicelli, Jeannette L, Ginsberg, Jill, Pawel, Bruce, Barr, Frederic G

“…In the pediatric cancer alveolar rhabdomyosarcoma (ARMS), the 2;13 chromosomal translocation juxtaposes the PAX3 and FKHR genes to generate a chimeric…”
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Chromosomal translocations and sarcomas by Bennicelli, Jeannette L, Barr, Frederic G

“…This review examines how the identification of tumor-specific translocations and fusion proteins has advanced the basic scientific and clinical understanding…”
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Production of multiple cytokines by cultured human melanomas by Bennicelli, J L, Guerry, 4th, D

“…We screened a panel of 8 primary and 21 metastatic melanoma cell lines for constitutive secretion of cytokines. Melanomas expressed bioactivity for TGF-beta…”
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647 Upregulation of MET but not NCAM expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma by Ginsberg, J. P., Davis, R. J., Bennicelli, J. L., Nauta, L. E., Barr, F. G.

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