Search Results - "Bennett, Stuart"

Adaptation of Syntenic Xyloglucan Utilization Loci of Human Gut Bacteroidetes to Polysaccharide Side Chain Diversity by Déjean, Guillaume, Tauzin, Alexandra S, Bennett, Stuart W, Creagh, A Louise, Brumer, Harry

“…Genome sequencing has revealed substantial variation in the predicted abilities of individual species within animal gut microbiota to metabolize the complex…”
Get full text

ChESS – Quick and robust detection of chess-board features by Bennett, Stuart, Lasenby, Joan

“…•An efficient and reliable method for detecting chess-board vertices is proposed.•The detector is robust to rotation, blur, and poor scene lighting and…”
Get full text

Age‐associated changes in long‐chain fatty acid profile during healthy aging promote pro‐inflammatory monocyte polarization via PPARγ by Pararasa, Chathyan, Ikwuobe, John, Shigdar, Shahjahan, Boukouvalas, Alexis, Nabney, Ian T., Brown, James E., Devitt, Andrew, Bailey, Clifford J., Bennett, Stuart J., Griffiths, Helen R.

“…Summary Differences in lipid metabolism associate with age‐related disease development and lifespan. Inflammation is a common link between metabolic…”
Get full text

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients by Hammond, Thomas G, Meng, Xiaoli, Jenkins, Rosalind E, Maggs, James L, Castelazo, Anahi Santoyo, Regan, Sophie L, Bennett, Stuart N L, Earnshaw, Caroline J, Aithal, Guruprasad P, Pande, Ira, Kenna, J Gerry, Stachulski, Andrew V, Park, B Kevin, Williams, Dominic P

“…Covalent protein modifications by electrophilic acyl glucuronide (AG) metabolites are hypothetical causes of hypersensitivity reactions associated with certain…”
Get more information

Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies by Weber, Daniela, Milkovic, Lidija, Bennett, Stuart J, Griffiths, Helen R, Zarkovic, Neven, Grune, Tilman

“…There is increasing evidence that non-enzymatic post-translational protein modifications might play key roles in various diseases. These protein modifications…”
Get full text

Free-Wilson and Structural Approaches to Co-optimizing Human and Rodent Isoform Potency for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitors by Goldberg, Frederick W., Leach, Andrew G., Scott, James S., Snelson, Wendy L., Groombridge, Sam D., Donald, Craig S., Bennett, Stuart N. L., Bodin, Cristian, Gutierrez, Pablo Morentin, Gyte, Amy C.

“…11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) has been a target of intensive research efforts across the pharmaceutical industry, due to its potential for the…”
Get full text

Ultra-endurance exercise: unanswered questions in redox biology and immunology by Turner, James E, Bennett, Stuart J, Bosch, Jos A, Griffiths, Helen R, Aldred, Sarah

“…Ultra-endurance races are extreme exercise events that can take place over large parts of a day, several consecutive days or over weeks and months interspersed…”
Get more information

Thioredoxin as a putative biomarker and candidate target in age-related immune decline by Griffiths, Helen R, Bennett, Stuart J, Olofsson, Peter, Dunston, Christopher R

“…The oxidoreductase Trx-1 (thioredoxin 1) is highly conserved and found intra- and extra-cellularly in mammalian systems. There is increasing interest in its…”
Get more information

A safe and scalable synthesis of 2-hydroxy-3-alkoxypropionates by epoxide ring opening by Waring, Michael J., Bennett, Stuart N.L., Campbell, Leonie, Hallam, Stephen, Martin, Nathaniel G., Tickner, Christopher

“…[Display omitted] Epoxides are useful precursors for the synthesis of hydroxyl-bearing building blocks via Lewis acid catalyzed, nucleophilic ring opening…”
Get full text

Free radicals and redox signalling in T-cells during chronic inflammation and ageing by Griffiths, Helen R, Dunston, Christopher R, Bennett, Stuart J, Grant, Melissa M, Phillips, Darren C, Kitas, George D

“…During chronic inflammation and ageing, the increase in oxidative stress in both intracellular and extracellular compartments is likely to influence local cell…”
Get more information

Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non‐ketotic hyperglycinemia by Leung, Kit‐Yi, De Castro, Sandra C. P., Santos, Chloe, Savery, Dawn, Prunty, Helen, Gold‐Diaz, Diana, Bennett, Stuart, Heales, Simon, Copp, Andrew J., Greene, Nicholas D. E.

“…Glycine abundance is modulated in a tissue‐specific manner by use in biosynthetic reactions, catabolism by the glycine cleavage system (GCS), and excretion via…”
Get full text

Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function? by Torrão, Rita C., Bennett, Stuart J., Brown, James E., Griffiths, Helen R.

“…T cells are required for an effective adaptive immune response. The principal function of T cells is to promote efficient removal of foreign material by…”
Get full text

Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion by Carilho Torrao, Rita Barreto Duarte, Dias, Irundika HK, Bennett, Stuart J, Dunston, Christopher R, Griffiths, Helen R

“…Background During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione…”
Get full text

Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies by Whittamore, Paul R.O., Addie, Matthew S., Bennett, Stuart N.L., Birch, Alan M., Butters, Michael, Godfrey, Linda, Kenny, Peter W., Morley, Andrew D., Murray, Paul M., Oikonomakos, Nikos G., Otterbein, Ludovic R., Pannifer, Andrew D., Parker, Jeremy S., Readman, Kristy, Siedlecki, Pawel S., Schofield, Paul, Stocker, Andy, Taylor, Melvyn J., Townsend, Linda A., Whalley, David P., Whitehouse, Jennifer

“…Novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase are described, in particular: SAR, hepatocyte activity and binding at the…”
Get full text

Problem Solving: Can Anybody Do It? by Bennett, Stuart W

“…This paper examines the definition of a problem and at the process of problem solving. An analysis of a number of first and third year chemistry examination…”
Get more information

Discovery of a series of indan carboxylic acid glycogen phosphorylase inhibitors by Bennett, Stuart N.L., Campbell, Andrew D., Hancock, Andrew, Johnstone, Craig, Kenny, Peter W., Pickup, Adrian, Plowright, Alleyn T., Selmi, Nidhal, Simpson, Iain, Stocker, Andy, Whalley, David P., Whittamore, Paul R.O.

“…A series of carboxylic acid glycogen phosphorylase inhibitors, which have potential as oral antidiabetic agents, is described. Defining and applying simple…”
Get full text

CD4+ T cell surface alpha enolase is lower in older adults by Bennett, Stuart J., Augustyniak, Edyta M., Dunston, Christopher R., Brown, Richard A., Shantsila, Eduard, Lip, Gregory Y.H., Torrao, Rita D.C., Pararasa, Chathyan, Remtulla, Ali H., Ladouce, Romain, Friguet, Bertrand, Griffiths, Helen R.

“…•α-Enolase is lower on the surface of CD4+ T cell in healthy older adults.•Cardiovascular disease patients express less CD4+ T cell α-enolase than age-matched…”
Get full text

Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: lifecourse study by Lamont, Douglas, Parker, Louise, White, Martin, Unwin, Nigel, Bennett, Stuart M A, Cohen, Melanie, Richardson, David, Dickinson, Heather O, Adamson, Ashley, Alberti, K G M, Craft, Alan W

“…Abstract Objective: To quantify the direct and indirect effects of fetal life, childhood, and adult life on risk of cardiovascular disease at age 49–51 years…”
Get full text

Sensitive non-isotopic assays for autoantibodies to IA-2 and to a combination of both IA-2 and GAD65 by Chen, Shu, Willis, Jinny, Maclean, Clare, Ananieva-Jordanova, Rossitza, Amoroso, Marie-Andrée, Brooking, Helen, Powell, Michael, Collins, Anne, Bennett, Stuart, Mitchell, Sarah, Burne, Peter, Furmaniak, Jadwiga, Smith, Bernard Rees

“…A sensitive ELISA for measurement of IA-2 autoantibodies has been developed and assessed. Also, a combination ELISA for detection of both GAD65 autoantibodies…”
Get full text

Oxidative stress in vascular dementia and Alzheimer's disease: a common pathology by Bennett, Stuart, Grant, Melissa M, Aldred, Sarah

“…Alzheimer's disease and vascular dementia are the two most common types of dementia with the former being the most predominant. It is evident that oxidative…”
Get more information