Search Results - "Bennett, P. B."

Cloning and Functional Expression of Two Families of β-Subunits of the Large Conductance Calcium-activated K+ Channel by Uebele, Victor N., Lagrutta, Armando, Wade, Theresa, Figueroa, David J., Liu, Yuan, McKenna, Edward, Austin, Christopher P., Bennett, Paul B., Swanson, Richard

“…We report here a characterization of two families of calcium-activated K+ channel β-subunits, β2 and β3, which are encoded by distinct genes that map to…”
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Molecular mechanism for an inherited cardiac arrhythmia by Bennett, Paul B, Yazawa, Kazuto, Makita, Naomasa, George, Alfred L

“…In the congenital long-QT syndrome, prolongation of the cardiac action potential occurs by an unknown mechanism and predisposes individuals to syncope and…”
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Pharmacological targeting of long QT mutant sodium channels by Wang, D W, Yazawa, K, Makita, N, George, Jr, A L, Bennett, P B

“…The congenital long QT syndrome (LQTS) is an inherited disorder characterized by a delay in cardiac cellular repolarization leading to cardiac arrhythmias and…”
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Heteromultimeric Assembly of Human Potassium Channels Molecular Basis of a Transient Outward Current? by Po, S, Roberds, S, Snyders, D J, Tamkun, M M, Bennett, P B

“…To gain insight into the molecular basis of cardiac repolarization, we have expressed K channels cloned from ventricular myocardium in Xenopus oocytes. A…”
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A rapidly activating and slowly inactivating potassium channel cloned from human heart : functional analysis after stable mammalian cell culture expression by SNYDERS, D. J, TAMKUN, M. M, BENNETT, P. B

“…The electrophysiological properties of HK2 (Kv1.5), a K+ channel cloned from human ventricle, were investigated after stable expression in a mouse Ltk- cell…”
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Modulation of HERG Potassium Channels by Extracellular Magnesium and Quinidine by Po, S S, Wang, D W, Yang, Iris Chun-Hui, Johnson, J P, Nie, Li, Bennett, P B

“…Torsades de pointes is a polymorphic ventricular arrhythmia resulting from congenital or drug-induced (acquired) QT prolongation. Pharmacologic suppression of…”
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Suppression of Time-Dependent Outward Current in Guinea Pig Ventricular Myocytes: Actions of Quinidine and Amiodarone by Balser, Jeffrey R, Bennett, Paul B, Hondeghem, Luc M, Roden, Dan M

“…Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing and arrhythmia-aggravating actions of antiarrhythmic agents. In this…”
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The incidence of venous gas emboli in recreational diving by Dunford, R G, Vann, R D, Gerth, W A, Pieper, C F, Huggins, K, Wacholtz, C, Bennett, P B

“…From 1989-91, the Divers Alert Network monitored recreational divers for Doppler-detected venous gas emboli (VGE) and depth-time profiles following multi-day,…”
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Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers by Freiberger, J J, Derrick, B J, Natoli, M J, Akushevich, I, Schinazi, E A, Parker, C, Stolp, B W, Bennett, P B, Vann, R D, Dunworth, S A S, Moon, R E

“…Diving narcosis results from the complex interaction of gases, activities, and environmental conditions. We hypothesized that these interactions could be…”
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Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes by VALENZUELA, C, SNYDERS, D. J, BENNETT, P. B, TAMARGO, J, HONDEGHEM, L. M

“…Bupivacaine is a potent local anesthetic widely used for prolonged local and regional anesthesia. However, accidental intravascular injection of bupivacaine…”
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Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels by Yang, I C, Scherz, M W, Bahinski, A, Bennett, P B, Murray, K T

“…Selective inhibitors of the slow component of the cardiac delayed rectifier K(+) current, I(Ks), are of interest as novel class III antiarrhythmic agents and…”
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A Novel Extracellular Calcium Sensing Mechanism in Voltage-Gated Potassium Ion Channels by Johnson, J. P., Jr, Balser, Jeffrey R, Bennett, Paul B

“…Potassium (K(+)) channels influence neurotransmitter release, burst firing rate activity, pacing, and critical dampening of neuronal circuits. Internal and…”
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Functional expression and properties of the human skeletal muscle sodium channel by MOHAMED CHAHINE, BENNETT, P. B, GEORGE, A. L, HORN, R

“…Full-length deoxyribonucleic acid, complementary (cDNA) constructs encoding the alpha-subunit of the adult human skeletal muscle Na+ channel, hSkM1, were…”
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Characterization of a Voltage-Gated K+Channel β Subunit Expressed in Human Heart by England, S K, Uebele, V N, Shear, H, Kodali, J, Bennett, P B, Tamkun, M M

“…Voltage-gated K+channels are important modulators of the cardiac action potential. However, the correlation of endogenous myocyte currents with K+channels…”
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On the molecular nature of the lidocaine receptor of cardiac NA+ channels : modification of block by alterations in the α-subunit III-IV interdomain by BENNETT, P. B, VALENZUELA, C, LI-QIONG CHEN, KALLEN, R. G

“…The mechanism of inhibition of Na+ channels by lidocaine has been suggested to involve low-affinity binding to rested states and high-affinity binding to the…”
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A molecular basis for gating mode transitions in human skeletal muscle Na + channels by Bennett, Paul B., Makita, Naomasa, George, Alfred L.

“…Recombinant sodium channel α subunits expressed in Xenopus oocytes display an anomalously slow rate of inactivation that arises from channels that…”
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A deep stop during decompression from 82 fsw (25 m) significantly reduces bubbles and fast tissue gas tensions by Marroni, A, Bennett, P B, Cronje, F J, Cali-Corleo, R, Germonpre, P, Pieri, M, Bonuccelli, C, Balestra, C

“…In spite of many modifications to decompression algorithms, the incidence of decompression sickness (DCS) in scuba divers has changed very little. The success…”
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Functional Expression of an Inactivating Potassium Channel Cloned From Human Heart by Po, S, Snyders, D J, Baker, R, Tamkun, M M, Bennett, P B

“…Recently a putative K channel with homology to the Shaker family of potassium channels has been cloned from human ventricular myocardium. However, proof that…”
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Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin by Valenzuela, C., Bennett, P.B.

“…Single cardiac Na+ channels were investigated after intracellular proteolysis to remove the fast inactivation process in an attempt to elucidate the mechanisms…”
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Multiple domains contribute to the distinct inactivation properties of human heart and skeletal muscle Na+ channels by MAKITA, N, BENNETT, P. B, GEORGE, A. L

“…Voltage-gated Na+ channels are essential for the normal electrical excitability of neuronal and striated muscle membranes. Distinct isoforms of the Na+ channel…”
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