Search Results - "Bennett, Martin R"

Vascular Smooth Muscle Cells in Atherosclerosis by Bennett, Martin R, Sinha, Sanjay, Owens, Gary K

“…The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that aberrant proliferation of VSMCs promotes plaque formation, but that…”
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Vascular smooth muscle cells in atherosclerosis: time for a re-assessment by Grootaert, Mandy O J, Bennett, Martin R

“…Abstract Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage atherosclerosis. VSMCs invade the early atherosclerotic lesion…”
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Vascular smooth muscle cells in atherosclerosis by Basatemur, Gemma L., Jørgensen, Helle F., Clarke, Murray C. H., Bennett, Martin R., Mallat, Ziad

“…Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the ‘response to injury’ and…”
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The Role of Oxidative Stress in Atherosclerosis by Batty, Matthew, Bennett, Martin R, Yu, Emma

“…Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading cause of cardiovascular diseases worldwide. Excessive generation of…”
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SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis by Grootaert, Mandy O.J., Finigan, Alison, Figg, Nichola L., Uryga, Anna K., Bennett, Martin R.

“…Vascular smooth muscle cell (VSMC) senescence promotes atherosclerosis and features of plaque instability, in part, through lipid-mediated oxidative DNA damage…”
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Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels by Dobnikar, Lina, Taylor, Annabel L., Chappell, Joel, Oldach, Phoebe, Harman, Jennifer L., Oerton, Erin, Dzierzak, Elaine, Bennett, Martin R., Spivakov, Mikhail, Jørgensen, Helle F.

“…Vascular smooth muscle cells (VSMCs) show pronounced heterogeneity across and within vascular beds, with direct implications for their function in injury…”
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Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models by Chappell, Joel, Harman, Jennifer L, Narasimhan, Vagheesh M, Yu, Haixiang, Foote, Kirsty, Simons, Benjamin D, Bennett, Martin R, Jørgensen, Helle F

“…RATIONALE:Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation…”
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Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms by Clément, Marc, Chappell, Joel, Raffort, Juliette, Lareyre, Fabien, Vandestienne, Marie, Taylor, Annabel L, Finigan, Alison, Harrison, James, Bennett, Martin R, Bruneval, Patrick, Taleb, Soraya, Jørgensen, Helle F, Mallat, Ziad

“…OBJECTIVE—Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm…”
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Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration by Bargehr, Johannes, Ong, Lay Ping, Colzani, Maria, Davaapil, Hongorzul, Hofsteen, Peter, Bhandari, Shiv, Gambardella, Laure, Le Novère, Nicolas, Iyer, Dharini, Sampaziotis, Fotios, Weinberger, Florian, Bertero, Alessandro, Leonard, Andrea, Bernard, William G., Martinson, Amy, Figg, Nichola, Regnier, Michael, Bennett, Martin R., Murry, Charles E., Sinha, Sanjay

“…The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic…”
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Role of biomechanical forces in the natural history of coronary atherosclerosis by Brown, Adam J., Teng, Zhongzhao, Evans, Paul C., Gillard, Jonathan H., Samady, Habib, Bennett, Martin R.

“…Key Points Atherosclerotic plaques are not uniformly distributed throughout the coronary tree, indicating that local mechanical factors might determine plaque…”
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Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation by Zheng, Yue, Humphry, Melanie, Maguire, Janet J., Bennett, Martin R., Clarke, Murray C.H.

“…Necrosis can induce profound inflammation or be clinically silent. However, the mechanisms underlying such tissue specificity are unknown. Interleukin-1α…”
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Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition by Costopoulos, Charis, Timmins, Lucas H, Huang, Yuan, Hung, Olivia Y, Molony, David S, Brown, Adam J, Davis, Emily L, Teng, Zhongzhao, Gillard, Jonathan H, Samady, Habib, Bennett, Martin R

“…Abstract Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical factors may influence plaque development. Methods and results…”
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Myocardin regulates vascular smooth muscle cell inflammatory activation and disease by Ackers-Johnson, Matthew, Talasila, Amarnath, Sage, Andrew P, Long, Xiaochun, Bot, Ilze, Morrell, Nicholas W, Bennett, Martin R, Miano, Joseph M, Sinha, Sanjay

“…Atherosclerosis, the cause of 50% of deaths in westernized societies, is widely regarded as a chronic vascular inflammatory disease. Vascular smooth muscle…”
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Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway by Warboys, Christina M, de Luca, Amalia, Amini, Narges, Luong, Le, Duckles, Hayley, Hsiao, Sarah, White, Alex, Biswas, Shukti, Khamis, Ramzi, Chong, Chuh K, Cheung, Wai-Mun, Sherwin, Spencer J, Bennett, Martin R, Gil, Jesus, Mason, Justin C, Haskard, Dorian O, Evans, Paul C

“…OBJECTIVE—Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately…”
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Exploring the relationship between biomechanical stresses and coronary atherosclerosis by Cameron, James N., Mehta, Ojas H., Michail, Michael, Chan, Jasmine, Nicholls, Stephen J., Bennett, Martin R., Brown, Adam J.

“…The pathophysiology of coronary atherosclerosis is multifaceted. Plaque initiation and progression are governed by a complex interplay between genetic and…”
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Distinct Epigenomic Features in End-Stage Failing Human Hearts by MOVASSAGH, Mehregan, CHOY, Mun-Kit, GODDARD, Martin, LIO, Pietro, BENNETT, Martin R, FOO, Roger S.-Y, KNOWLES, David A, CORDEDDU, Lina, HAIDER, Syed, DOWN, Thomas, SIGGENS, Lee, VUJIC, Ana, SIMEONI, Ilenia, PENKETT, Chris

“…The epigenome refers to marks on the genome, including DNA methylation and histone modifications, that regulate the expression of underlying genes. A…”
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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis by Bennett, Martin R, Clarke, Murray C H, Figg, Nichola, Maguire, Janet J, Davenport, Anthony P, Goddard, Martin, Littlewood, Trevor D

“…Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including aneurysm formation, angioplasty restenosis and atherosclerosis…”
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Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration by Clarke, Murray C.H, Littlewood, Trevor D, Figg, Nichola, Maguire, Janet J, Davenport, Anthony P, Goddard, Martin, Bennett, Martin R

“…Vascular smooth muscle cell (VSMC) accumulation is implicated in plaque development. In contrast, VSMC apoptosis is implicated in plaque rupture, coagulation,…”
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The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice by Mercer, John R., Yu, Emma, Figg, Nichola, Cheng, Kian-Kai, Prime, Tracy A., Griffin, Julian L., Masoodi, Mojgan, Vidal-Puig, Antonio, Murphy, Michael P., Bennett, Martin R.

“…A number of recent studies suggest that mitochondrial oxidative damage may be associated with atherosclerosis and the metabolic syndrome. However, much of the…”
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Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma by Brown, Adam J, Obaid, Daniel R, Costopoulos, Charis, Parker, Richard A, Calvert, Patrick A, Teng, Zhongzhao, Hoole, Stephen P, West, Nick E J, Goddard, Martin, Bennett, Martin R

“…Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology…”
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