Search Results - "Bennett, Mariko L"

A polarizing answer — microglia in Nasu-Hakola disease by Bennett, Mariko L.

“…A new study by Zhou et al. identifies a unique microglia state in Nasu-Hakola disease and new potential therapeutic targets…”
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Microglia: Scapegoat, Saboteur, or Something Else? by Aguzzi, Adriano, Barres, Ben A., Bennett, Mariko L.

“…Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases…”
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The influence of environment and origin on brain resident macrophages and implications for therapy by Bennett, Mariko L., Bennett, F. Chris

“…Microglia are the tissue-resident macrophages of the brain and spinal cord. They are critical players in the development, normal function, and decline of the…”
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A Combination of Ontogeny and CNS Environment Establishes Microglial Identity by Bennett, F. Chris, Bennett, Mariko L., Yaqoob, Fazeela, Mulinyawe, Sara B., Grant, Gerald A., Hayden Gephart, Melanie, Plowey, Edward D., Barres, Ben A.

“…Microglia, the brain’s resident macrophages, are dynamic CNS custodians with surprising origins in the extra-embryonic yolk sac. The consequences of their…”
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What are activated and reactive glia and what is their role in neurodegeneration? by Bennett, Mariko L., Viaene, Angela N.

“…In injury and disease, microglia and astrocytes - two major non-neuronal cell types in the central nervous system (CNS) - undergo morphological,…”
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Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing by Li, Qingyun, Cheng, Zuolin, Zhou, Lu, Darmanis, Spyros, Neff, Norma F., Okamoto, Jennifer, Gulati, Gunsagar, Bennett, Mariko L., Sun, Lu O., Clarke, Laura E., Marschallinger, Julia, Yu, Guoqiang, Quake, Stephen R., Wyss-Coray, Tony, Barres, Ben A.

“…Microglia are increasingly recognized for their major contributions during brain development and neurodegenerative disease. It is currently unknown whether…”
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Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity by Rodda, Lauren B., Lu, Erick, Bennett, Mariko L., Sokol, Caroline L., Wang, Xiaoming, Luther, Sanjiv A., Barres, Ben A., Luster, Andrew D., Ye, Chun Jimmie, Cyster, Jason G.

“…Stromal cells (SCs) establish the compartmentalization of lymphoid tissues critical to the immune response. However, the full diversity of lymph node (LN) SCs…”
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An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex by Zhang, Ye, Chen, Kenian, Sloan, Steven A, Bennett, Mariko L, Scholze, Anja R, O'Keeffe, Sean, Phatnani, Hemali P, Guarnieri, Paolo, Caneda, Christine, Ruderisch, Nadine, Deng, Shuyun, Liddelow, Shane A, Zhang, Chaolin, Daneman, Richard, Maniatis, Tom, Barres, Ben A, Wu, Jian Qian

“…The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and…”
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New tools for studying microglia in the mouse and human CNS by Bennett, Mariko L., Bennett, F. Chris, Liddelow, Shane A., Ajami, Bahareh, Zamanian, Jennifer L., Fernhoff, Nathaniel B., Mulinyawe, Sara B., Bohlen, Christopher J., Adil, Aykezar, Tucker, Andrew, Weissman, Irving L., Chang, Edward F., Li, Gordon, Grant, Gerald A., Gephart, Melanie G. Hayden, Barres, Ben A.

“…The specific function of microglia, the tissue resident macrophages of the brain and spinal cord, has been difficult to ascertain because of a lack of tools to…”
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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

“…Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its…”
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Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors by Allen, Nicola J., Bennett, Mariko L., Foo, Lynette C., Wang, Gordon X., Chakraborty, Chandrani, Smith, Stephen J., Barres, Ben A.

“…Glypican 4 and glypican 6 are identified as astrocyte-secreted signals that induce the formation of functional, rather than structural, synapses through the…”
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Isolation and Culture of Microglia by Bohlen, Christopher J, Bennett, F Chris, Bennett, Mariko L

“…Microglia represent 5-10% of cells in the central nervous system and contribute to the development, homeostasis, injury, and repair of neural tissues. As the…”
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Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth by Yao, Maojin, Ventura, P. Britten, Jiang, Ying, Rodriguez, Fausto J., Wang, Lixin, Perry, Justin S.A., Yang, Yibo, Wahl, Kelsey, Crittenden, Rowena B., Bennett, Mariko L., Qi, Lin, Gong, Cong-Cong, Li, Xiao-Nan, Barres, Ben A., Bender, Timothy P., Ravichandran, Kodi S., Janes, Kevin A., Eberhart, Charles G., Zong, Hui

“…The tumor microenvironment (TME) is critical for tumor progression. However, the establishment and function of the TME remain obscure because of its complex…”
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Microglia in antiviral immunity of the brain and spinal cord by O’Brien, Carleigh A., Bennett, F. Chris, Bennett, Mariko L.

“…Viral infections of the central nervous system (CNS) are a significant cause of neurological impairment and mortality worldwide. As tissue resident…”
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A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan by Su, Yijing, Zhou, Yi, Bennett, Mariko L., Li, Shiying, Carceles-Cordon, Marc, Lu, Lu, Huh, Sooyoung, Jimenez-Cyrus, Dennisse, Kennedy, Benjamin C., Kessler, Sudha K., Viaene, Angela N., Helbig, Ingo, Gu, Xiaosong, Kleinman, Joel E., Hyde, Thomas M., Weinberger, Daniel R., Nauen, David W., Song, Hongjun, Ming, Guo-li

“…The molecular diversity of glia in the human hippocampus and their temporal dynamics over the lifespan remain largely unknown. Here, we performed…”
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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

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Microglia cannibalism during neurodevelopment results in necroptotic cell death by Bennett, F Chris, Bennett, Mariko L

“…Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that…”
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Neurotoxic reactive astrocytes are induced by activated microglia by Liddelow, Shane A., Guttenplan, Kevin A., Clarke, Laura E., Bennett, Frederick C., Bohlen, Christopher J., Schirmer, Lucas, Bennett, Mariko L., Münch, Alexandra E., Chung, Won-Suk, Peterson, Todd C., Wilton, Daniel K., Frouin, Arnaud, Napier, Brooke A., Panicker, Nikhil, Kumar, Manoj, Buckwalter, Marion S., Rowitch, David H., Dawson, Valina L., Dawson, Ted M., Stevens, Beth, Barres, Ben A.

“…Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. Here we show that a subtype…”
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Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma by Hutter, Gregor, Theruvath, Johanna, Graef, Claus Moritz, Zhang, Michael, Schoen, Matthew Kenneth, Manz, Eva Maria, Bennett, Mariko L., Olson, Andrew, Azad, Tej D., Sinha, Rahul, Chan, Carmel, Kahn, Suzana Assad, Gholamin, Sharareh, Wilson, Christy, Grant, Gerald, He, Joy, Weissman, Irving L., Mitra, Siddhartha S., Cheshier, Samuel H.

“…Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been…”
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Microglia modulate neurodevelopment in human neuroimmune organoids by Bennett, Mariko L, Song, Hongjun, Ming, Guo-Li

“…Dissecting contributions of microglia to human brain development and disease pathogenesis requires modeling interactions between these microglia and their…”
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