Search Results - "Bennett, Jeffrey L"

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies by Papadopoulos, Marios C., Bennett, Jeffrey L., Verkman, Alan S.

“…Key Points Most patients with neuromyelitis optica (NMO) have serum IgG antibodies against astrocytic aquaporin-4 (AQP4) channels, a minority have antibodies…”
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Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases by Weil, Marie-Theres, Möbius, Wiebke, Winkler, Anne, Ruhwedel, Torben, Wrzos, Claudia, Romanelli, Elisa, Bennett, Jeffrey L., Enz, Lukas, Goebels, Norbert, Nave, Klaus-Armin, Kerschensteiner, Martin, Schaeren-Wiemers, Nicole, Stadelmann, Christine, Simons, Mikael

“…Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of…”
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Serum Glial Fibrillary Acidic Protein: A Neuromyelitis Optica Spectrum Disorder Biomarker by Aktas, Orhan, Smith, Michael A., Rees, William A., Bennett, Jeffrey L., She, Dewei, Katz, Eliezer, Cree, Bruce A. C., Fujihara, Kazuo, Paul, Friedemann, Hartung, Hans‐Peter, Marignier, Romain, Kim, Ho Jin, Weinshenker, Brian G., Pittock, Sean J., Wingerchuk, Dean M., Cutter, Gary R., Green, Ari J., Mealy, Maureen A., Drappa, Jorn

“…Objective Blood tests to monitor disease activity, attack severity, or treatment impact in neuromyelitis optica spectrum disorder (NMOSD) have not been…”
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Membrane assembly of aquaporin-4 autoantibodies regulates classical complement activation in neuromyelitis optica by Soltys, John, Liu, Yiting, Ritchie, Alanna, Wemlinger, Scott, Schaller, Kristin, Schumann, Hannah, Owens, Gregory P, Bennett, Jeffrey L

“…Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG). Although…”
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Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder by Chen, John J., Flanagan, Eoin P., Bhatti, M. Tariq, Jitprapaikulsan, Jiraporn, Dubey, Divyanshu, Lopez Chiriboga, Alfonso (Sebastian) S., Fryer, James P., Weinshenker, Brian G., McKeon, Andrew, Tillema, Jan-Mendelt, Lennon, Vanda A., Lucchinetti, Claudia F., Kunchok, Amy, McClelland, Collin M., Lee, Michael S., Bennett, Jeffrey L., Pelak, Victoria S., Van Stavern, Gregory, Adesina, Ore-Ofe O., Eggenberger, Eric R., Acierno, Marie D., Wingerchuk, Dean M., Lam, Byron L., Moss, Heather, Beres, Shannon, Gilbert, Aubrey L., Shah, Veeral, Armstrong, Grayson, Heidary, Gena, Cestari, Dean M., Stiebel-Kalish, Hadas, Pittock, Sean J.

“…OBJECTIVEMyelin oligodendrocyte glycoprotein–immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks…”
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Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms by Zhang, Hua, Bennett, Jeffrey L., Verkman, A. S.

“…Objective: Neuromyelitis optica (NMO) is a neuroinflammatory disease of spinal cord and optic nerve associated with serum autoantibodies (NMO–immunoglobulin G…”
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Concentration-dependent effects of CSF1R inhibitors on oligodendrocyte progenitor cells ex vivo and in vivo by Liu, Yiting, Given, Katherine S., Dickson, Erin L., Owens, Gregory P., Macklin, Wendy B., Bennett, Jeffrey L.

“…Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in CNS development, maintenance and repair. The…”
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Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica by Tradtrantip, Lukmanee, Zhang, Hua, Saadoun, Samira, Phuan, Puay-Wah, Lam, Chiwah, Papadopoulos, Marios C., Bennett, Jeffrey L., Verkman, A. S.

“…Objective: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO‐immunoglobulin…”
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Finding NMO: The Evolving Diagnostic Criteria of Neuromyelitis Optica by Bennett, Jeffrey L

“…Neuromyelitis optica (NMO) is an autoimmune demyelinating disorder of the central nervous system (CNS) with predilection for the optic nerves and spinal cord…”
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Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica by Bennett, Jeffrey L., Lam, Chiwah, Kalluri, Sudhakar Reddy, Saikali, Philippe, Bautista, Katherine, Dupree, Cecily, Glogowska, Magdalena, Case, David, Antel, Jack P., Owens, Gregory P., Gilden, Don, Nessler, Stefan, Stadelmann, Christine, Hemmer, Bernhard

“…Objective The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO‐IgGs) directed against the aquaporin‐4 (AQP4) water channel…”
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Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays by Crane, Jonathan M., Lam, Chiwah, Rossi, Andrea, Gupta, Tripta, Bennett, Jeffrey L., Verkman, A.S.

“…Autoantibodies against astrocyte water channel aquaporin-4 (AQP4) are highly specific for the neuroinflammatory disease neuromyelitis optica (NMO). We measured…”
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Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination by Peschl, Patrick, Schanda, Kathrin, Zeka, Bleranda, Given, Katherine, Böhm, Denise, Ruprecht, Klemens, Saiz, Albert, Lutterotti, Andreas, Rostásy, Kevin, Höftberger, Romana, Berger, Thomas, Macklin, Wendy, Lassmann, Hans, Bradl, Monika, Bennett, Jeffrey L, Reindl, Markus

“…Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system…”
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Acute Management of Optic Neuritis: An Evolving Paradigm by Horton, Lindsay, Bennett, Jeffrey L

“…The current management of acute optic neuritis (ON) is focused on expediting visual recovery through the use of high-dose intravenous corticosteroids. The…”
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Blood-brain barrier resealing in neuromyelitis optica occurs independently of astrocyte regeneration by Winkler, Anne, Wrzos, Claudia, Haberl, Michael, Weil, Marie-Theres, Gao, Ming, Möbius, Wiebke, Odoardi, Francesca, Thal, Dietmar R, Chang, Mayland, Opdenakker, Ghislain, Bennett, Jeffrey L, Nessler, Stefan, Stadelmann, Christine

“…Approximately 80% of neuromyelitis optica spectrum disorder (NMOSD) patients harbor serum anti-aquaporin-4 autoantibodies targeting astrocytes in the CNS…”
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Neuromyelitis optica IgG causes placental inflammation and fetal death by Saadoun, Samira, Waters, Patrick, Leite, M Isabel, Bennett, Jeffrey L, Vincent, Angela, Papadopoulos, Marios C

“…Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the CNS and affects women of childbearing age. Most patients with NMO have circulating…”
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Intravenous neuromyelitis optica autoantibody in mice targets aquaporin-4 in peripheral organs and area postrema by Ratelade, Julien, Bennett, Jeffrey L, Verkman, A S

“…The pathogenesis of neuromyelitis optica (NMO) involves binding of IgG autoantibodies (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous…”
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Dural sinus stent placement for idiopathic intracranial hypertension by Kumpe, David A, Bennett, Jeffrey L, Seinfeld, Joshua, Pelak, Victoria S, Chawla, Ashish, Tierney, Mary

“…The use of unilateral dural sinus stent placement in patients with idiopathic intracranial hypertension (IIH) has been described by multiple investigators. To…”
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Specific Induction of Double Negative B Cells During Protective and Pathogenic Immune Responses by Ruschil, Christoph, Gabernet, Gisela, Lepennetier, Gildas, Heumos, Simon, Kaminski, Miriam, Hracsko, Zsuzsanna, Irmler, Martin, Beckers, Johannes, Ziemann, Ulf, Nahnsen, Sven, Owens, Gregory P, Bennett, Jeffrey L, Hemmer, Bernhard, Kowarik, Markus C

“…Double negative (DN) (CD19 CD20 CD27 IgD ) B cells are expanded in patients with autoimmune and infectious diseases; however their role in the humoral immune…”
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Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1-anchored membrane domains by Owens, Gregory P, Fellin, Timothy J, Matschulat, Adeline, Salas, Vanessa, Schaller, Kristin L, Given, Katherine S, Ritchie, Alanna M, Navarro, Andre, Blauth, Kevin, Hughes, Ethan G, Macklin, Wendy B, Bennett, Jeffrey L

“…B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS)…”
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Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis by Nagel, Maria A, White, Teresa, Khmeleva, Nelly, Rempel, April, Boyer, Philip J, Bennett, Jeffrey L, Haller, Andrea, Lear-Kaul, Kelly, Kandasmy, Balasurbramaniyam, Amato, Malena, Wood, Edward, Durairaj, Vikram, Fogt, Franz, Tamhankar, Madhura A, Grossniklaus, Hans E, Poppiti, Robert J, Bockelman, Brian, Keyvani, Kathy, Pollak, Lea, Mendlovic, Sonia, Fowkes, Mary, Eberhart, Charles G, Buttmann, Mathias, Toyka, Klaus V, Meyer-ter-Vehn, Tobias, Petursdottir, Vigdis, Gilden, Don

“…Giant cell arteritis (GCA) is the most common systemic vasculitis in elderly individuals. Diagnosis is confirmed by temporal artery (TA) biopsy, although…”
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