Search Results - "Bennett, David A"

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study by Arvanitakis, Zoe, Prof, Capuano, Ana W, PhD, Leurgans, Sue E, Prof, Bennett, David A, Prof, Schneider, Julie A, Prof

“…Summary Background Few data on the pathology of cerebral vessel disease, dementia, and cognition are available. We examined the association of cerebral…”
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Alzheimer's disease in African Americans: risk factors and challenges for the future by Barnes, Lisa L, Bennett, David A

“…As the US elderly population continues to expand rapidly, Alzheimer's disease poses a major and increasing public health challenge, and older African Americans…”
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Sex differences in Alzheimer’s disease and common neuropathologies of aging by Oveisgharan, Shahram, Arvanitakis, Zoe, Yu, Lei, Farfel, Jose, Schneider, Julie A., Bennett, David A.

“…Alzheimer’s dementia is significantly more common in women than in men. However, few pathological studies have addressed sex difference in Alzheimer’s disease…”
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Person‐specific contribution of neuropathologies to cognitive loss in old age by Boyle, Patricia A., Yu, Lei, Wilson, Robert S., Leurgans, Sue E., Schneider, Julie A., Bennett, David A.

“…Objective Mixed neuropathologies are the most common cause of dementia at the population level, but how different neuropathologies contribute to cognitive…”
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Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons by Lim, Andrew S P, Kowgier, Matthew, Yu, Lei, Buchman, Aron S, Bennett, David A

“…Cross-sectional studies suggest that sleep fragmentation is associated with cognitive performance in older adults. We tested the hypothesis that sleep…”
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Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project by Wallace, Lindsay M K, Theou, Olga, Godin, Judith, Andrew, Melissa K, Bennett, David A, Rockwood, Kenneth

“…Some people with substantial Alzheimer's disease pathology at autopsy had shown few characteristic clinical symptoms or signs of the disease, whereas others…”
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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease by Zhang, Bin, Gaiteri, Chris, Bodea, Liviu-Gabriel, Wang, Zhi, McElwee, Joshua, Podtelezhnikov, Alexei A., Zhang, Chunsheng, Xie, Tao, Tran, Linh, Dobrin, Radu, Fluder, Eugene, Clurman, Bruce, Melquist, Stacey, Narayanan, Manikandan, Suver, Christine, Shah, Hardik, Mahajan, Milind, Gillis, Tammy, Mysore, Jayalakshmi, MacDonald, Marcy E., Lamb, John R., Bennett, David A., Molony, Cliona, Stone, David J., Gudnason, Vilmundur, Myers, Amanda J., Schadt, Eric E., Neumann, Harald, Zhu, Jun, Emilsson, Valur

“…The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the…”
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Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis by Huo, Zhiguang, Yu, Lei, Yang, Jingyun, Zhu, Yun, Bennett, David A., Zhao, Jinying

“…The development of Alzheimer's dementia (AD) accompanies both central and peripheral metabolic disturbance, but the metabolic basis underlying AD and metabolic…”
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To what degree is late life cognitive decline driven by age-related neuropathologies? by Boyle, Patricia A, Wang, Tianhao, Yu, Lei, Wilson, Robert S, Dawe, Robert, Arfanakis, Konstantinos, Schneider, Julie A, Bennett, David A

“…The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated that the three most studied of these, Alzheimer's disease, infarcts,…”
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Attributable risk of Alzheimer's dementia attributed to age‐related neuropathologies by Boyle, Patricia A., Yu, Lei, Leurgans, Sue E., Wilson, Robert S., Brookmeyer, Ron, Schneider, Julie A., Bennett, David A.

“…Objective The degree to which Alzheimer's versus other neuropathologies contribute to the risk of Alzheimer's dementia is unknown. We examined the risk of…”
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Mixed pathologies and neural reserve: Implications of complexity for Alzheimer disease drug discovery by Bennett, David A

“…In a Perspective, David Bennett makes a case for neural reserve to be considered as a therapeutic endpoint in clinical trials for dementia…”
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Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons by Boyle, Patricia A, Yu, Lei, Nag, Sukriti, Leurgans, Sue, Wilson, Robert S, Bennett, David A, Schneider, Julie A

“…OBJECTIVE:We tested the hypothesis that cerebral amyloid angiopathy (CAA) is related to Alzheimer disease (AD) dementia and decline in multiple cognitive…”
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Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes by Blanchard, Joel W., Bula, Michael, Davila-Velderrain, Jose, Akay, Leyla Anne, Zhu, Lena, Frank, Alexander, Victor, Matheus B., Bonner, Julia Maeve, Mathys, Hansruedi, Lin, Yuan-Ta, Ko, Tak, Bennett, David A., Cam, Hugh P., Kellis, Manolis, Tsai, Li-Huei

“…In Alzheimer’s disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood–brain…”
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An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome by Ng, Bernard, White, Charles C, Klein, Hans-Ulrich, Sieberts, Solveig K, McCabe, Cristin, Patrick, Ellis, Xu, Jishu, Yu, Lei, Gaiteri, Chris, Bennett, David A, Mostafavi, Sara, De Jager, Philip L

“…This paper reports the availability of a new Resource with RNA-seq, DNA methylation and H3K9Ac QTL results from 411 brain samples. Many xQTL SNPs influence…”
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Brain pathology contributes to simultaneous change in physical frailty and cognition in old age by Buchman, Aron S, Yu, Lei, Wilson, Robert S, Boyle, Patricia A, Schneider, Julie A, Bennett, David A

“…First, we tested the hypothesis that the rate of change of physical frailty and cognitive function in older adults are correlated. Next, we examined if their…”
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Normative Cognitive Decline in Old Age by Wilson, Robert S., Wang, Tianhao, Yu, Lei, Bennett, David A., Boyle, Patricia A.

“…Objective To characterize trajectories of normative cognitive aging. Methods Older persons without dementia at study enrollment (n = 1,010) had annual…”
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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues by Zhu, Jiang, Adli, Mazhar, Zou, James Y., Verstappen, Griet, Coyne, Michael, Zhang, Xiaolan, Durham, Timothy, Miri, Mohammad, Deshpande, Vikram, De Jager, Philip L., Bennett, David A., Houmard, Joseph A., Muoio, Deborah M., Onder, Tamer T., Camahort, Ray, Cowan, Chad A., Meissner, Alexander, Epstein, Charles B., Shoresh, Noam, Bernstein, Bradley E.

“…Differences in chromatin organization are key to the multiplicity of cell states that arise from a single genetic background, yet the landscapes of in vivo…”
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Plasma Exosomal miRNAs in Persons with and without Alzheimer Disease: Altered Expression and Prospects for Biomarkers by Lugli, Giovanni, Cohen, Aaron M, Bennett, David A, Shah, Raj C, Fields, Christopher J, Hernandez, Alvaro G, Smalheiser, Neil R

“…To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the expression of microRNAs was measured in a plasma fraction enriched in…”
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Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease by Nag, Sukriti, Yu, Lei, Capuano, Ana W., Wilson, Robert S., Leurgans, Sue E., Bennett, David A., Schneider, Julie A.

“…Objective To investigate the association of hippocampal sclerosis (HS) with TAR‐DNA binding protein of 43kDa (TDP‐43) and other common age‐related pathologies,…”
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Charting a dynamic DNA methylation landscape of the human genome by Ziller, Michael J., Gu, Hongcang, Müller, Fabian, Donaghey, Julie, Tsai, Linus T.-Y., Kohlbacher, Oliver, De Jager, Philip L., Rosen, Evan D., Bennett, David A., Bernstein, Bradley E., Gnirke, Andreas, Meissner, Alexander

“…Whole-genome bisulphite sequencing data from diverse human cell and tissue types shows that only about 22% of CpGs change their methylation state across these…”
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