Search Results - "Bennett, Chad"

Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression by Li, Zhefeng, Wang, Hongzhi, Yin, Hongran, Bennett, Chad, Zhang, Huang-ge, Guo, Peixuan

“…Exosomes have shown increasing potential as delivery vesicles for therapy, but challenges like cost/yield, drug payload, and targeting specificity still exist…”
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Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Yu, Peter Y, Gardner, Heather L, Roberts, Ryan, Cam, Hakan, Hariharan, Seethalakshmi, Ren, Ling, LeBlanc, Amy K, Xiao, Hui, Lin, Jiayuh, Guttridge, Denis C, Mo, Xiaokui, Bennett, Chad E, Coss, Christopher C, Ling, Yonghua, Phelps, Mitch A, Houghton, Peter, London, Cheryl A

“…STAT3 is a transcription factor involved in cytokine and receptor kinase signal transduction that is aberrantly activated in a variety of sarcomas, promoting…”
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Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer by Datta, Jharna, Willingham, Natalie, Manouchehri, Jasmine M, Schnell, Patrick, Sheth, Mirisha, David, Joel J, Kassem, Mahmoud, Wilson, Tyler A, Radomska, Hanna S, Coss, Christopher C, Bennett, Chad E, Ganju, Ramesh K, Sardesai, Sagar D, Lustberg, Maryam, Ramaswamy, Bhuvaneswari, Stover, Daniel G, Cherian, Mathew A

“…Among women, breast cancer is the leading cause of cancer-related death worldwide. Estrogen receptor α-positive (ERα+) breast cancer accounts for 70% of all…”
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Acid-Promoted Prins Cyclizations of Enol Ethers To Form Tetrahydropyrans by Hart, David J, Bennett, Chad E

“…Trifluoroacetic acid efficiently catalyzes Prins cyclizations of enol ethers 8 to provide tetrahydropyrans 9 and 10. These tetrahydropyrans are isolated with…”
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Pyrimidine depletion enhances targeted and immune therapy combinations in acute myeloid leukemia by Elgamal, Ola A, Fobare, Sydney, Vibhute, Sandip, Mehmood, Abeera, Vroom, Dennis C, Johnson, Mariah L, Stearns, Blaise, Lerma, James R, Truxall, Jean, Stahl, Emily, Carmichael, Bridget, Orwick, Shelley J, Mims, Alice S, Curran, Emily, Santhanam, Ramasamy, Tridandapani, Susheela, Phelps, Mitch A, Xie, Zhiliang, Coss, Christopher C, Baker, Sharyn D, Patrick, Jeffrey, Ezzell, Janel K, Rai, Jayesh, Pan, Jianmin, Rai, Shesh N, Stillwell, Cody, Wunderlich, Mark, Abdulrahim, Mouad, Goodwin, Thomas E, Hilinski, Gerard, Bennett, Chad E, Hertlein, Erin, Byrd, John C

“…Acute myeloid leukemia (AML) is a fatal disease characterized by the accumulation of undifferentiated myeloblasts, and agents that promote differentiation have…”
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Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain by Bennett, Chad E., Burnett, Duane A., Greenlee, William J., Knutson, Chad E., Korakas, Peter, Li, Cheng, Tulshian, Deen, Wu, Wen-Lian, Bertorelli, Rosalia, Fredduzzi, Silva, Grilli, Mariagrazia, Lozza, Gianluca, Reggiani, Angelo, Veltri, Alessio

“…A series of fused tricyclic mGluR1 antagonists containing a pyridone ring were synthesized. In vitro, these antagonists were potent against both human and rat…”
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Iminoheterocycles as γ-secretase modulators by Caldwell, John P., Bennett, Chad E., McCracken, Troy M., Mazzola, Robert D., Bara, Thomas, Buevich, Alexei, Burnett, Duane A., Chu, Inhou, Cohen-Williams, Mary, Josein, Hubert, Hyde, Lynn, Lee, Julie, McKittrick, Brian, Song, Lixin, Terracina, Giuseppe, Voigt, Johannes, Zhang, Lili, Zhu, Zhaoning

“…The synthesis of a novel series of iminoheterocycles and their structure–activity relationship (SAR) as modulators of γ-secretase activity will be detailed…”
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The Practical Synthesis of a Novel and Highly Potent Analogue of Bryostatin by Wender, Paul A, Baryza, Jeremy L, Bennett, Chad E, Bi, F. Christopher, Brenner, Stacey E, Clarke, Michael O, Horan, Joshua C, Kan, Cindy, Lacôte, Emmanuel, Lippa, Blaise, Nell, Peter G, Turner, Tim M

“…Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar…”
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A Highly Stereoselective Synthesis of 2-Deoxy-β-glycosides Using 2-Deoxy-2-iodo-glucopyranosyl Acetate Donors by Roush, William R, Bennett, Chad E

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Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain by Brumfield, Stephanie, Korakas, Peter, Silverman, Lisa S., Tulshian, Deen, Matasi, Julius J., Qiang, Li, Bennett, Chad E., Burnett, Duane A., Greenlee, William J., Knutson, Chad E., Wu, Wen-Lian, Sasikumar, T.K., Domalski, Martin, Bertorelli, Rosalia, Grilli, Mariagrazia, Lozza, Gianluca, Reggiani, Angelo, Li, Cheng

“…High throughput screening identified the pyridothienopyrimidinone 1 as a ligand for the metabotropic glutamate receptor 1 (mGluR1=10nM). Compound 1 has an…”
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A Highly Stereoselective Synthesis of the Landomycin A Hexasaccharide Unit by Roush, William R, Bennett, Chad E

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Substituent Effects on the Regiochemical and Stereochemical Course of the Nussbaumer-Frater Variation of the Prins Cyclization by J. Hart, David, E. Bennett, Chad, Figueroa, Ruth, Yang, Dexi

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2-Deoxy-2-iodo- and 2-Deoxy-2-bromo-α-glucopyranosyl Trichloroacetimidates:  Highly Reactive and Stereoselective Donors for the Synthesis of 2-Deoxy-β-glycosides by Roush, William R, Gung, Benjamin W, Bennett, Chad E

“…2-Deoxy-2-iodo- and 2-deoxy-2-bromoglucopyranosyl trichloroacetimidates 8 − 10 and 22 are extremely useful precursors of 2-deoxy-β-glycosides. These reactive…”
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SAR of tricyclic sulfones as γ-secretase inhibitors by Xu, Ruo, Cole, David, Asberom, Ted, Bara, Tom, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Hyde, Lynn, Josien, Hubert, Li, HongMei, McBriar, Mark, McKittrick, Brian, Pissarnitski, Dmitri, Qiang, Li, Rajagopalan, Murali, Sasikumar, Thavalakulamgara, Su, Jing, Tang, HaiQun, Wu, Wen-Lian, Zhang, LiLi, Zhao, ZhiQiang

“…Novel tricyclic sulfones as γ-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer＇s disease Compounds in this series have…”
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Understanding systemic problems in providing mental health services to people with an intellectual disability and co-morbid mental disorders in Victoria by Bennett, Chad

“…Objective: This paper explores the difficulties the services system in Victoria has in responding to people with intellectual disability (ID) and mental health…”
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Discovery of Nanomolar Inhibitors for Human Dihydroorotate Dehydrogenase Using Structure-Based Drug Discovery Methods by Higgins, William T., Vibhute, Sandip, Bennett, Chad, Lindert, Steffen

“…We used a structure-based drug discovery approach to identify novel inhibitors of human dihydroorotate dehydrogenase (DHODH), which is a therapeutic target for…”
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Iodoacetoxylation of Glycals Using Cerium(IV) Ammonium Nitrate, Sodium Iodide, and Acetic Acid:  Stereoselective Synthesis of 2-Deoxy-2-iodo-α-mannopyranosyl Acetates by Roush, William R, Narayan, Sridhar, Bennett, Chad E, Briner, Karin

“…The reactions of glycals with ceric(IV) ammonium nitrate and sodium iodide in the presence of acetic acid provides 2-deoxy-2-iodo-α-mannopyranosyl acetates…”
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Synthesis of Furans by SN2' Cyclization of .gamma.-Alkynyl Allylic Alcohol Derivatives by Marshall, James A, Bennett, Chad E

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Studies on the Synthesis of Landomycin A:  Synthesis and Glycosidation Reactions of l-Rhodinosyl Acetate Derivatives by Roush, William R, Bennett, Chad E, Roberts, Sara E

“…An efficient, eight-step synthesis of l-rhodinosyl acetate derivative 3 is described. The synthesis originates from methyl (S)-lactate and involves a highly…”
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Hosu-53, a Novel Potent Dihydroorotate Dehydrogenase Inhibitor Accentuates CD47 Blockade Therapy Resulting in Long Term Survival in Acute Myeloid Leukemia by Elgamal, Ola A, Vibhute, Sandip, Stearns, Blaise, Tridandapani, Susheela, Goodwin, Thomas E, Hilinski, Gerard, Bennett, Chad, Patrick, Jeffrey, Hertlein, Erin, Byrd, John C.

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