Search Results - "Bennallack, Philip R"

Capture of micrococcin biosynthetic intermediates reveals C-terminal processing as an obligatory step for in vivo maturation by Bewley, Kathryn D., Bennallack, Philip R., Burlingame, Mark A., Robison, Richard A., Griffitts, Joel S., Miller, Susan M.

“…Thiopeptides, including micrococcins, are a growing family of bioactive natural products that are ribosomally synthesized and heavily modified. Here we use a…”
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Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilis by Bennallack, Philip R, Bewley, Kathryn D, Burlingame, Mark A, Robison, Richard A, Miller, Susan M, Griffitts, Joel S

“…Thiopeptides represent one of several families of highly modified peptide antibiotics that hold great promise for natural product engineering. These…”
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Micrococcin cysteine-to-thiazole conversion through transient interactions between the scaffolding protein TclI and the modification enzymes TclJ and TclN by Calvopina-Chavez, Diana G, Bursey, Devan M, Tseng, Yi-Jie, Patil, Leena M, Bewley, Kathryn D, Bennallack, Philip R, McPhie, Josh M, Wagstaff, Kimberly B, Daley, Anisha, Miller, Susan M, Moody, James D, Price, John C, Griffitts, Joel S

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a broad group of compounds mediating microbial competition in nature…”
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Characterization of a Novel Plasmid-Borne Thiopeptide Gene Cluster in Staphylococcus epidermidis Strain 115 by Bennallack, Philip R, Burt, Scott R, Heder, Michael J, Robison, Richard A, Griffitts, Joel S

“…Thiopeptides are small (12- to 17-amino-acid), heavily modified peptides of bacterial origin. This antibiotic family, with more than 100 known members, is…”
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Elucidating and engineering thiopeptide biosynthesis by Bennallack, Philip R., Griffitts, Joel S.

“…Initially discovered in the mid-twentieth century, thiopeptides constitute a diverse family of bacterially produced natural products exhibiting a remarkable…”
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A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells by Knapman, Alisa, Santiago, Marina, Du, Yan Ping, Bennallack, Philip R, Christie, Macdonald J, Connor, Mark

“…Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual…”
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Galloyl Carbohydrates with Antiangiogenic Activity Mediated by Capillary Morphogenesis Gene 2 (CMG2) Protein Binding by G.-Doyagüez, Elisa, Carrero, Paula, Madrona, Andrés, Rodriguez-Salamanca, Patricia, Martínez-Gualda, Belén, Camarasa, María José, Jimeno, María Luisa, Bennallack, Philip R, Finnell, Jordan G, Tsang, Tsz-Ming, Christensen, Kenneth A, San-Félix, Ana, Rogers, Michael S

“…We previously showed that a small molecule of natural origin, 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose (PGG), binds to capillary morphogenesis gene 2 (CMG2)…”
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Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice by Zaninelli, Tiago H., Fattori, Victor, Heintz, Olivia K., Wright, Kristeena R., Bennallack, Philip R., Sim, Danielle, Bukhari, Hussain, Terry, Kathryn L., Vitonis, Allison F., Missmer, Stacey A., Andrello, Avacir C., Anchan, Raymond M., Godin, Stephen K., Bree, Dara, Verri Jr, Waldiceu A., Rogers, Michael S.

“…[Display omitted] •Neurotrophic factors are key to endometriosis pathophysiology and pain.•VEGFR1 activation is not required for endometriosis-associated pain…”
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