Search Results - "Benkovic, Patricia A."

Peptide Synthesis Catalyzed by an Antibody Containing a Binding Site for Variable Amino Acids by Hirschmann, Ralph, Smith, Amos B., Taylor, Carol M., Benkovic, Patricia A., Taylor, Scott D., Yager, Kraig M., Sprengeler, Paul A., Benkovic, Stephen J.

“…Monoclonal antibodies, induced with a phosphonate diester hapten, catalyzed the coupling of p-nitrophenyl esters of N-acetyl valine, leucine, and phenylalanine…”
Get full text

Cyclic Peptide Formation Catalyzed by an Antibody Ligase by Smithrud, David B., Benkovic, Patricia A., Benkovic, Stephen J., Roberts, Victoria, Liu, Josephine, Neagu, Irina, Iwama, Seiji, Phillips, Barton W., Smith, Amos B., Hirschmann, Ralph

“…Cyclic hexapeptides represent a class of compounds with important, diverse biological activities. We report herein that the antibody 16G3 catalyzes the…”
Get full text

Substituent effects of an antibody-catalyzed hydrolysis of phenyl esters: further evidence for an acyl-antibody intermediate by Gibbs, Richard A, Benkovic, Patricia A, Janda, Kim D, Lerner, Richard A, Benkovic, Stephen J

“…The hydrolysis of a series of para-substituted phenyl esters by the monoclonal catalytic antibody NPN43C9 has been investigated. The observations are…”
Get full text

Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator by Maryanoff, Bruce E, Reitz, Allen B, Tutwiler, Gene F, Benkovic, Stephen J, Benkovic, Patricia A, Pilkis, Simon J

Get full text

Investigations of an Antibody Ligase by Smithrud, David B, Benkovic, Patricia A, Benkovic, Stephen J, Taylor, Carol M, Yager, Kraig M, Witherington, Jason, Philips, Barton W, Sprengeler, Paul A, Smith, Amos B, Hirschmann, Ralph

“…Further investigation of the monoclonal antibody 16G3 has revealed that it not only couples activated amino acids to form dipeptides with high turnover rates…”
Get full text

Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-) by Eger, Bryan T, Kuchta, Robert D, Carroll, Steven S, Benkovic, Patricia A, Dahlberg, Michael E, Joyce, Catherine M, Benkovic, Stephen J

“…Inhibition of the pre-steady-state burst of nucleotide incorporation by a single incorrect nucleotide (nucleotide discrimination) was measured with the Klenow…”
Get full text

Catalytic antibody for imide hydrolysis featuring a bifunctional transition-state mimic by Liotta, Louis J, Benkovic, Patricia A, Miller, Grover P, Benkovic, Stephen J

“…Monoclonal antibodies raised against tetrahedral transition-state analogs have consistently been shown to catalyze acyl transfer reactions. Antibodies…”
Get full text

Antibody-Catalyzed Rearrangement of a Peptide Bond: Mechanistic and Kinetic Investigations by Liotta, Louis J, Gibbs, Richard A, Taylor, Scott D, Benkovic, Patricia A, Benkovic, Stephen J

Get full text

Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigations by Janda, Kim D, Ashley, Jon A, Jones, Teresa M, McLeod, Donald A, Schloeder, Diane M, Weinhouse, Michael I, Lerner, Richard A, Gibbs, Richard A, Benkovic, Patricia A

“…Antibodies have been shown to catalyze acyl-transfer reactions. The processes by which they perform such tasks have often been postulated but largely remain…”
Get full text

On the cofactor specificity of glycinamide ribonucleotide and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase from chicken liver by Smith, Gary K, Mueller, W. Thomas, Benkovic, Patricia A, Benkovic, Stephen J

“…Tests of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and glycinamide ribonucleotide (GAR) transformylase cofactor specificity were conducted with…”
Get full text

Studies on 6-methyl-5-deazatetrahydropterin and its 4a adducts by Moad, Graeme, Luthy, Connie L, Benkovic, Patricia A, Benkovic, Stephen J

Get full text

Studies on Sulfate Esters. I. Nucleophilic Reactions of Amines with p-Nitrophenyl Sulfate by Benkovic, Stephen J, Benkovic, Patricia A

Get full text

Binding and kinetic data for rabbit liver fructose 1, 6 bisphosphatase with Zn2+ as cofactor by Benkovic, P.A, Caperelli, C.A, De Maine, M, Benkovic, S.J

“…Atomic absorption determinations of zinc content were employed to demonstrate the technique to obtain zinc-free rabbit liver fructose-1,6-bisphosphatase…”
Get full text

Catalytic Reactions of Phosphoglucose Isomerase with Cyclic Forms of Glucose 6-Phosphate and Fructose 6-Phosphate by Schray, K J, Benkovic, S J, Benkovic, P A, Rose, I A

“…Yeast phosphoglucose isomerase is shown to use and produce both the α and the β anomeric forms of fructofuranose 6-phosphate. Rapid quench techniques show a…”
Get full text

Studies on sulfate esters. III. A comparison of the solvolyses of salicyl sulfate and sulfur trioxide by Benkovic, Stephen J, Benkovic, Patricia A

Get full text

Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate by Tatum, Charles M, Benkovic, Patricia A, Benkovic, Stephen J, Potts, Rowell, Schleicher, Erwin, Floss, Heinz G

“…The stereochemistry of the transfer catalyzed by rabbit liver serine transhydroxymethylase (EC 2.1.2.1) of the prochiral hydroxymethyl group from serine to…”
Get full text

Studies on models for tetrahydrofolic acid. II. Additional observations on the mechanism for condensation of formaldehyde with tetrahydroquinoxaline analogs by Benkovic, Stephen J, Benkovic, Patricia A, Chrzanowski, Robert

Get full text

Anomeric specificity of yeast pyruvate kinase toward activation by D-fructose 1,6-bisphosphate by Fishbein, Richard, Benkovic, Patricia A, Benkovic, Stephen J

Get full text

Investigation of the pre-steady-state kinetics of fructose bisphosphatase by employment of an indicator method by Benkovic, Patricia A, Hegazi, Mohammed, Cunningham, Brian A, Benkovic, Stephen J

“…The pre-steady-state kinetics for the hydrolysis of fructose 1,6-bisphosphate by rabbit liver fructose bis-phosphatase have been investigated by stopped-flow…”
Get full text

Models for tetrahydrofolic acid. I. Condensation of formaldehyde with tetrahydroquinoxaline analogs by Benkovic, Stephen J, Benkovic, Patricia A, Comfort, David R

Get full text