Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report

Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness...

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Bibliographic Details
Published in:	International journal of particle therapy Vol. 13; p. 100626
Main Authors:	Ahmad, Reem, Barcellini, Amelia, Baumann, Kilian, Benje, Malte, Bender, Tamara, Bragado, Paloma, Charalampopoulou, Alexandra, Chowdhury, Reema, Davis, Anthony J., Ebner, Daniel K., Eley, John, Kloeber, Jake A., Mutter, Robert W., Friedrich, Thomas, Gutierrez-Uzquiza, Alvaro, Helm, Alexander, Ibáñez-Moragues, Marta, Iturri, Lorea, Jansen, Jeannette, Morcillo, Miguel Ángel, Puerta, Daniel, Kokko, Anggraeini Puspitasari, Sánchez-Parcerisa, Daniel, Scifoni, Emanuele, Shimokawa, Takashi, Sokol, Olga, Story, Michael D., Thariat, Juliette, Tinganelli, Walter, Tommasino, Francesco, Vandevoorde, Charlot, von Neubeck, Cläre
Format:	Journal Article
Language:	English
Published:	United States Elsevier B.V 01-09-2024 Particle Therapy Cooperative Group (PTCOG)
Subjects:	Bragg peak Particle therapy Radiobiology Review Bragg peak Particle therapy Radiobiology
Online Access:	Get full text
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Summary:	Particle therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of the charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance their capability to treat radioresistant tumors, including hypoxic ones. Over the years, extensive research has paved the way for PT's clinical application, and current efforts aim to refine its efficacy and precision, minimizing the toxicities. In this regard, radiobiology research is evolving toward integrating biotechnology to advance drug discovery and radiation therapy optimization. This shift from basic radiobiology to understanding the molecular mechanisms of PT aims to expand the therapeutic window through innovative dose delivery regimens and combined therapy approaches. This review, written by over 30 contributors from various countries, provides a comprehensive look at key research areas and new developments in PT radiobiology, emphasizing the innovations and techniques transforming the field, ranging from the radiobiology of new irradiation modalities to multimodal radiation therapy and modeling efforts. We highlight both advancements and knowledge gaps, with the aim of improving the understanding and application of PT in oncology.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	2331-5180 2331-5180
DOI:	10.1016/j.ijpt.2024.100626