Search Results - "Benjamin, E.J."

Atherogenic lipid stress induces platelet hyperactivity through CD36-mediated hyposensitivity to prostacyclin: the role of phosphodiesterase 3A by Berger, Martin, Raslan, Zaher, Aburima, Ahmed, Magwenzi, Simbarashe, Wraith, Katie S, Spurgeon, Benjamin E J, Hindle, Matthew S, Law, Robert, Febbraio, Maria, Naseem, Khalid M

“…Prostacyclin (PGI ) controls platelet activation and thrombosis through a cyclic adenosine monophosphate (cAMP) signaling cascade. However, in patients with…”
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Platelet Flow Cytometry: Instrument Setup, Controls, and Panel Performance by Spurgeon, Benjamin E.J., Naseem, Khalid M.

“…Platelet flow cytometry is widely used in cardiovascular medicine as the platelet surface is rich in clinical biomarkers. Surface profiling is critical in…”
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Interpretation of time-to-event outcomes in randomized trials: an online randomized experiment by Weir, I.R., Marshall, G.D., Schneider, J.I., Sherer, J.A., Lord, E.M., Gyawali, B., Paasche-Orlow, M.K., Benjamin, E.J., Trinquart, L.

“…Multiple features in the presentation of randomized controlled trial (RCT) results are known to influence comprehension and interpretation. We aimed to compare…”
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High-Throughput Signaling Profiling in Blood Platelets by Multiplexed Phosphoflow Cytometry by Spurgeon, Benjamin E J, Naseem, Khalid M

“…Multiplexed phosphoflow cytometry is a novel method that provides rapid and quantitative readouts on intracellular phosphoprotein signaling. In this approach,…”
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Head and neck teratomas in children—A series of 23 cases at Great Ormond Street Hospital by Alexander, Victoria Rebecca Carol, Manjaly, Joseph George, Pepper, Christopher M, Ifeacho, Sonna N, Hewitt, Richard J, Hartley, Benjamin E.J

“…Abstract Objective Head and neck teratomas are rare and malignant change is rarer still. This is a report detailing all of the teratomas treated by the ear,…”
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Primary cervical ganglioneuroblastoma by Manjaly, Joseph G, Alexander, Victoria R.C, Pepper, Christopher M, Ifeacho, Sonna N, Hewitt, Richard J, Hartley, Benjamin E.J

“…Abstract Objectives Ganglioneuroblastomas represent a histological subgroup of the rare neuroblastic tumours with intermediate malignant potential arising from…”
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Heart failure in rural Haiti: Descriptive epidemiology and outcomes by Kwan, G.F., Jean Baptiste, W., Benjamin, E.J., Hirschhorn, L.R.

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Clinical and genetic correlates of soluble P‐selectin in the community by LEE, D. S., LARSON, M. G., LUNETTA, K. L., DUPUIS, J., RONG, J., KEANEY, J. F., LIPINSKA, I., BALDWIN, C. T., VASAN, R. S., BENJAMIN, E. J.

“…Background:  P‐selectin is a cell adhesion molecule that is involved in atherogenesis, and soluble concentrations of this biomarker reflect cardiovascular…”
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Cross-sectional relations of serum aldosterone and urine sodium excretion to urinary albumin excretion in a community-based sample by Fox, C.S., Larson, M.G., Hwang, S.-J., Leip, E.P., Rifai, N., Levy, D., Benjamin, E.J., Murabito, J.M., Meigs, J.B., Vasan, R.S.

“…Experimental models suggest that increased aldosterone and sodium intake are associated with renovascular damage and resultant proteinuria. We hypothesized…”
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Transfer function-derived central pressure and cardiovascular events: The Framingham Heart Study by Mitchell, G.F, Hwang, S.-J, Larson, M.J, Hamburg, N.M, Benjamin, E.J, Vasan, R.S, Levy, D, Vita, J.A

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Excision of nasal dermoids with intracranial extension—Anterior small window craniotomy approach by Heywood, Rebecca L, Lyons, Marie J, Cochrane, Lesley A, Hayward, Richard, Hartley, Benjamin E.J

“…Summary Objective Dermoid cysts are the most common midline congenital nasal masses and may extend intracranially. They commonly become infected, may distort…”
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Angiosarcoma of skull base in a 1-year-old child—A case report by Renukaswamy, Gayathri Mandya, Boardman, Simone J, Sebire, Neil J, Hartley, Benjamin E.J

“…Abstract Angiosarcoma is a rare tumour of endothelial cell origin whilst malignant skull base tumours are highly unusual in paediatric patients. This case…”
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2.2: Transfer Function-Derived Central Pressure and Cardiovascular Events: The Framingham Heart Study by Mitchell, G. F., Hwang, S. -J., Larson, M. J., Hamburg, N. M., Benjamin, E. J., Vasan, R. S., Levy, D., Vita, J. A.

“…Relations between central versus brachial blood pressure and major cardiovascular disease (CVD) events remain controversial. Central measures derived using…”
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Do Running Shoes Protect all Runners? by Spurgeon, Benjamin E J

“…Dear Editor-in-Chief Running is a prevalent physical activity in today’s health-conscious society. [...]running shoe research has been focused only on rearfoot…”
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Thrombospondin-1 promotes hemostasis through modulation of cAMP signaling in blood platelets by Aburima, Ahmed, Berger, Martin, Spurgeon, Benjamin E.J., Webb, Bethany A., Wraith, Katie S., Febbraio, Maria, Poole, Alastair W., Naseem, Khalid M.

“…Thrombospondin-1 (TSP-1) is released by platelets upon activation and can increase platelet activation, but its role in hemostasis in vivo is unclear. We show…”
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Persistent left cranial vena cava and right cranial vena cava aplasia in a French bulldog and a Cavalier King Charles spaniel with severe pulmonic stenosis by Huynh, J., Benjamin, E.J., Degarmo, K., Baumwart, R.

“…One French bulldog and one Cavalier King Charles spaniel were referred for pulmonary balloon valvuloplasty (PBV) after being diagnosed with severe pulmonic…”
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OMIP‐097: High‐parameter phenotyping of human platelets by spectral flow cytometry by Spurgeon, Benjamin E. J., Frelinger, Andrew L.

“…Using spectral flow cytometry, we developed a 16‐color panel for analysis of platelet phenotype and function in human whole blood. The panel contains markers…”
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Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin by Hindle, Matthew S., Spurgeon, Benjamin E. J., Cheah, Lih T., Webb, Beth A., Naseem, Khalid M.

“…Background Robust platelet activation leads to the generation of subpopulations characterized by differential expression of phosphatidylserine (PS)…”
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Comprehensive phenotyping of human platelets by single‐cell cytometry by Spurgeon, Benjamin E. J., Frelinger, Andrew L.

“…Platelets are small anucleate blood cells that contribute to hemostasis, immunity, and inflammation. Circulating platelets are heterogeneous in size, age,…”
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Clinical Cytometry for Platelets and Platelet Disorders by Frelinger, Andrew L., Spurgeon, Benjamin E.J.

“…Clinical flow cytometry tests for inherited and acquired platelet disorders are useful diagnostic tools but are not widely available. Flow cytometric methods…”
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